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贵州疣螈的核型和C-带研究 总被引:5,自引:0,他引:5
贵州疣螈的核型和C-带研究ASTUDYONKARYOTYPESANDC-BANDINGSOFTylototritonkweichowensis关键词贵州疣螈,核型,ZW-染色体,C-带KeywordsTylototritonkweichowensis... 相似文献
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EffectofEpidermalGrowthFactoronFollicularDevelopmentandSteroidogenesisinPerfusedRatOvary¥LUOWen-xiang(罗文祥);ZHAOFang(赵芳);MAKui... 相似文献
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用PCR法扩增出编码人FAS分子胞外区的cDNA片段,直接克隆到pGEM-T载体上,经DNA序列测定后,再插入到谷胱甘肽转硫酶(GST)融合蛋白表达载体pGEX-KG的EcoRⅠ和SalⅠ位点之间,构成重组质粒pKG-hFAS,将此质粒导入大肠杆菌,经IPTG诱导后获得GST-hFAS重组融合蛋白的表达,用谷胱甘肽偶联的Sepharose4B经亲合层析获得纯化的GST-hFAS蛋白,经凝血酶酶切和二次亲合层析去除GST部分,得到纯化的FAS蛋白.用纯化的FAS抗原免疫家兔制备了抗FAS抗体,经检测发现抗FAS抗体能诱导U937细胞发生细胞凋亡 相似文献
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^3H-TdR放射性转化细胞经1×10^-5mol/L Foskolin处理24h后,TGFa,c-myc,c-K-ras基因的mRNA表达下降;TGFβ,c-fos基因表达无明显变化。非转化细胞经相同条件处理,TGFa,TGFβ,c-myc及c-K-ras基因表达无显著改变。提示:Forskolin介导的转化细胞的生长抑制作用与TGFa,c-myc,c-K-ras基因的转录表达下降有关。 相似文献
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吸血蠓群落的地理分布 总被引:3,自引:0,他引:3
吸血蠓群落的地理分布GEOGRAPHICALDISTRIBUTIONOFBLOOD-SUCKINGMIDGECOMMUNITIES关键词吸血蠓群落,聚类分析,地理分布KeywordsBlood-suckingmidgecommunities,Clus... 相似文献
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MPFInductionofMicrotubuleAssemblyatInterphaseKinetochoreofCHOCellsFENGMei;(冯梅)ZHANGHuan-xiang;(张焕相)WANGYong-chao;(王永潮)WANGYue... 相似文献
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X. C. ZHANG 《植物研究》1998,18(1):107-117
GENUSANTROPHYUMKAULF.FROMCHINAANDNEIGHBORINGREGIONSX.C.ZHANG(Theherbarium(PE),InstituteofBotany,ChineseAcademyofSciences,Bei... 相似文献
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信号肽疏水性的提高促进青霉素G酰化酶分泌 总被引:9,自引:0,他引:9
设计和合成了一段具有连续10仆亮氨酸强疏水核心的信号肽(artificial signal peptide,ASP),由EcoRI-KpnI位点融合到青霉素G酰化酶(penicillin Gacylase,PAC)信号肽(wild typesignal peptide,WTSP)的-4Pro位点,分别构建了PAC表达质粒:pKKpac△SP,pKKpacWTSP,pKKpacASP,pETpac 相似文献
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Recent advances in the study of Kaposi's sarcoma-associated herpesvirus replication and pathogenesis
It has now been over twenty years since a novel herpesviral genome was identified in Kaposi's sarcoma biopsies. Since then, the cumulative research effort by molecular biologists, virologists, clinicians, and epidemiologists alike has led to the extensive characterization of this tumor virus, Kaposi's sarcoma-associated herpesvirus(KSHV; also known as human herpesvirus 8(HHV-8)), and its associated diseases. Here we review the current knowledge of KSHV biology and pathogenesis, with a particular emphasis on new and exciting advances in the field of epigenetics. We also discuss the development and practicality of various cell culture and animal model systems to study KSHV replication and pathogenesis. 相似文献
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正Dear Editor,In December 2019, a novel human coronavirus caused an epidemic of severe pneumonia(Coronavirus Disease 2019,COVID-19) in Wuhan, Hubei, China(Wu et al. 2020; Zhu et al. 2020). So far, this virus has spread to all areas of China and even to other countries. The epidemic has caused 67,102 confirmed infections with 1526 fatal cases 相似文献
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Curcumin is the yellow pigment of turmeric that interacts irreversibly forming an adduct with thioredoxin reductase (TrxR), an enzyme
responsible for redox control of cell and defence against oxidative stress. Docking at both the active sites of TrxR was performed to compare
the potency of three naturally occurring curcuminoids, namely curcumin, demethoxy curcumin and bis-demethoxy curcumin. Results show
that active sites of TrxR occur at the junction of E and F chains. Volume and area of both cavities is predicted. It has been concluded by
distance mapping of the most active conformations that Se atom of catalytic residue SeCYS498, is at a distance of 3.56 from C13 of
demethoxy curcumin at the E chain active site, whereas C13 carbon atom forms adduct with Se atom of SeCys 498. We report that at least
one methoxy group in curcuminoids is necessary for interation with catalytic residues of thioredoxin. Pharmacophore of both active sites of
the TrxR receptor for curcumin and demethoxy curcumin molecules has been drawn and proposed for design and synthesis of most probable
potent antiproliferative synthetic drugs. 相似文献
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RICHARD E. NORRIS 《Botanical journal of the Linnean Society. Linnean Society of London》1991,106(1):1-40
Comprises species occurring mostly in subtidal habitats in tropical, subtropical and warm-temperate areas of the world. An analysis of the type species, V. spiralis (Sonder) Lamouroux ex J. Agardh, a species from Australia, establishes basic characters for distinguishing species in the genus. These characters are (1) branching patterns of thalli, (2) flat blades that may be spiralled on their axis, (3) width of the blade, (4) primary or secondary derivation of sterile and fertile branchlets and (5) position of sterile and fertile branchlets on the thalli. Application of the latter two characters provides an important basic method for separation of species into three major groups. Osmundaria , a genus known only in southern Australia, was studied in relation to Vidalia , and its separation from the Vidalia assemblage is not accepted. Species of Vidalia therefore are transferred to the older genus name, Osmundaria. Two new species, Osmundaria papenfussii and Osmundaria oliveae are described from Natal. Confusion in the usage of the epithet, Vidalia fimbriala Brown ex Turner has been clarified, and Vidalia gregaria Falkenberg, described as an epiphyte on Osmundaria pro/ifera Lamouroux, is revealed to be young branches of the host, Osmundaria prolifera. 相似文献
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JOAN VALUÈS MONTSERRAT TORRELL NÚRIA GARCIA JACAS 《Botanical journal of the Linnean Society. Linnean Society of London》2001,137(4):399-407
Fifteen chromosome counts of six Artemisia taxa and one species of each of the genera Brachanthemum, Hippolytia, Kaschgaria, Lepidolopsis and Turaniphytum are reported from Kazakhstan. Three of them are new reports, two are not consistent with previous counts and the remainder are confirmations of very scarce (one to four) earlier records. All the populations studied have the same basic chromosome number, x = 9, with ploidy levels ranging from 2x to 6x. Some correlations between ploidy level, morphological characters and distribution are noted. 相似文献