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《生物加工过程》2016,(5)
以海藻酸钠为微丸载体材料,离子凝胶法制备戊己丸胃漂浮微丸。单因素实验考察了海藻酸钠质量浓度、Ca CO3与海藻酸钠质量比、海藻酸钠与固体分散体质量比、Ca Cl2质量浓度、醋酸质量浓度、Eudragit L100与提取物质量比对微丸的影响。在此基础上以持漂率为指标,采用星点设计-效应面法进一步优化其处方。筛选出最优处方:海藻酸钠20 g/L、Ca CO3与海藻酸钠质量比3.5、海藻酸钠与固体分散体质量比2、Ca Cl246 g/L、醋酸68 g/L、Eudragit L100与提取物质量比2。最终制备微丸体外持续漂浮超10 h,体外释放性能满足缓释制剂要求。此方法制备条件温和,制备工艺简单,效应面法所建立数学模型预测性好。 相似文献
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"发酵现象"是人教版《生物学》8年级上的"人类对细菌和真菌的利用"一节的演示实验,按照书上的要求只是观察现象并没有深入的探究,经过课堂实践,笔者把这个实验改为"探究酵母菌发酵作用产生了什么?" 相似文献
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鉴于目前高三生物学课复习具有盲目扩大复习范围、过多依赖复习资料,造成信息量增殖,复习效率下降的现象,提出了"典例分析法",分别从"典例"的典型性、分析视角及价值所进行探讨,以期提高学生的思维能力,真正提升复习的价值. 相似文献
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高血糖是糖尿病典型的病理特征,血糖的波动是决定糖尿病患者是否出现并发症的重要因素,而由胰岛β细胞合成分泌的胰岛素,是体内唯一可以降低血糖的多肽类激素.胰岛β细胞"质"与"量"决定着体内胰岛素分泌情况和血糖的调控.围绕"促进β细胞损伤修复,提升胰岛β细胞质量是治疗糖尿病的核心"之理念,提出构成胰岛β细胞"质"的三要素:细胞结构、"真""假"胰岛素和胰岛素调节型分泌.旨在为β细胞质量评价和糖尿病机制研究提供一定的理论参考. 相似文献
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继续医学教育项目" 过程管理模式" 体会 总被引:2,自引:0,他引:2
鲍银月贾建国樊洁 《现代生物医学进展》2011,11(11):2172-2173
继续医学教育项目是开展继续医学教育的重要形式之一,是卫生专业技术人员获取新知识、新理论、新技术、新方法的重要途径。项目执行的质量将直接体现继续医学教育质量。因此规范项目管理程序,建立有效的运行体系,建立严格奖罚制度,进行"过程跟踪管理"是保证项目执行质量的有效措施。 相似文献
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目的:建立肾衰康浓缩丸质量控制方法。方法:采用TLC鉴别肾衰康浓缩丸中大黄、丹参;采用HPLC-ELSD对制剂中黄芪甲苷进行含量测定,流动相为乙腈-水(30:70),流速:1 mL/min,柱温:28℃,漂移管温度:42℃,氮气:355kPa。结果:大黄、丹参的TLC鉴别斑点清晰、专属性强;黄芪甲苷在1.0μg-10.0μg之间呈良好的线性关系(r=0.9997,n=5),平均回收率为99.81%,RSD为1.73%(n=6)。结论:所建立的方法简便准确、专属性强、重现性好,可作为控制肾衰康浓缩丸质量的方法。 相似文献
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Recent advances in the study of Kaposi's sarcoma-associated herpesvirus replication and pathogenesis
It has now been over twenty years since a novel herpesviral genome was identified in Kaposi's sarcoma biopsies. Since then, the cumulative research effort by molecular biologists, virologists, clinicians, and epidemiologists alike has led to the extensive characterization of this tumor virus, Kaposi's sarcoma-associated herpesvirus(KSHV; also known as human herpesvirus 8(HHV-8)), and its associated diseases. Here we review the current knowledge of KSHV biology and pathogenesis, with a particular emphasis on new and exciting advances in the field of epigenetics. We also discuss the development and practicality of various cell culture and animal model systems to study KSHV replication and pathogenesis. 相似文献
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正Dear Editor,In December 2019, a novel human coronavirus caused an epidemic of severe pneumonia(Coronavirus Disease 2019,COVID-19) in Wuhan, Hubei, China(Wu et al. 2020; Zhu et al. 2020). So far, this virus has spread to all areas of China and even to other countries. The epidemic has caused 67,102 confirmed infections with 1526 fatal cases 相似文献
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Curcumin is the yellow pigment of turmeric that interacts irreversibly forming an adduct with thioredoxin reductase (TrxR), an enzyme
responsible for redox control of cell and defence against oxidative stress. Docking at both the active sites of TrxR was performed to compare
the potency of three naturally occurring curcuminoids, namely curcumin, demethoxy curcumin and bis-demethoxy curcumin. Results show
that active sites of TrxR occur at the junction of E and F chains. Volume and area of both cavities is predicted. It has been concluded by
distance mapping of the most active conformations that Se atom of catalytic residue SeCYS498, is at a distance of 3.56 from C13 of
demethoxy curcumin at the E chain active site, whereas C13 carbon atom forms adduct with Se atom of SeCys 498. We report that at least
one methoxy group in curcuminoids is necessary for interation with catalytic residues of thioredoxin. Pharmacophore of both active sites of
the TrxR receptor for curcumin and demethoxy curcumin molecules has been drawn and proposed for design and synthesis of most probable
potent antiproliferative synthetic drugs. 相似文献
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A.A. Zakeyah J. Whitt C. Duke D.F. Gilmore D.G. Meeker M.S. Smeltzer M.A. Alam 《Bioorganic & medicinal chemistry letters》2018,28(17):2914-2919
Microbial resistance to antibiotics is an unresolved global concern, which needs urgent and coordinated action. One of the guidelines of the Centers for Disease Control and Preventions (CDC) to combat antibiotic resistance is the development of new antibiotics to treat drug-resistant bacteria. In our effort to find new antibiotics, we report the synthesis and antimicrobial studies of 30 new pyrazole derivatives. These novel molecules have been synthesized by using readily available starting materials and benign reaction conditions. Some of these molecules have shown activity with MIC values as low as 0.78?µg/mL against four bacterial strains; Staphylococcus aureus, methicillin-resistant S. aureus, Bacillus subtilis, and Acinetobacter baumannii. Furthermore, active molecules are non-toxic to mammalian cell line. 相似文献
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The young pistils in the melanthioid tribes, Hewardieae, Petrosavieae and Tricyrteae, are uniformly tricarpellate and syncarpous. They lack raphide idioblasts. All are multiovulate, with bitegmic ovules. The Petrosavieae are marked by the presence of septal glands and incomplete syncarpy. Tepals and stamens adhere to the ovary in the Hewardieae and the Petrosavieae but not in the Tricyrteae. Two vascular bundles occur in the stamens of the Hewartlieae and Tricyrtis latifolia. Ventral bundles in the upper part of the ovary of the Hewardieae are continuous with compound septal bundles and placental bundles in the lower part. Putative ventral bundles occur in the alternate position in the Tricyrteae and putative placental bundles in the opposite. position in the Petrosavieae. The dichtomously branched stigma in each carpel of the Tricyrteae is supplied by a bifurcated dorsal bundle. 相似文献
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Zsófia Czudor Mária Balogh Péter Bánhegyi Sándor Boros Nóra Breza Judit Dobos Márk Fábián Zoltán Horváth Eszter Illyés Péter Markó Anna Sipos Csaba Szántai-Kis Bálint Szokol László Őrfi 《Bioorganic & medicinal chemistry letters》2018,28(4):769-773
Cyclin-dependent kinases (CDKs) and Polo-like kinases (PLKs) play key role in the regulation of the cell cycle. The aim of our study was originally the further development of our recently discovered polo-like kinase 1 (PLK1) inhibitors. A series of new 2,4-disubstituted pyrimidine derivatives were synthesized around the original hit, but their PLK1 inhibitory activity was very poor. However the novel compounds showed nanomolar CDK9 inhibitory activity and very good antiproliferative effect on multiple myeloma cell lines (RPMI-8226). 相似文献