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从海南哥纳香(Goniothalam ushow iiMerr. etChun)的种子分离到结晶V、VI和VII。根据它们的IR、1H-NMR、13C-NMR、MS分析及衍生物光谱分析,它们均属番荔枝内酯的新类型——裂双四氢呋喃型番荔枝内酯。晶V和晶VI分别命名为海南哥纳香丁素(how iicin D)和戊素(how iicin E)。晶VII系两个平面结构相同的化合物海南哥纳香己素和庚素(how iicins F,G)的混晶 相似文献
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从番荔枝(Annona squam osa L.)的种子中分离到A1—A7共7个化合物,其中A2、A3和A5为新的番荔枝内酯,分别命名为新-去乙酰紫玉盘素(neo-desacetyluvaricin, A2)、新阿诺宁乙(neo-annonin B, A3)和新牛心番荔枝素甲(neo-reticulatacin A, A5)。 相似文献
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滇产圆滑番荔枝中的番荔枝内酯 总被引:3,自引:0,他引:3
从滇南产的圆滑番荔枝的种子中得到4个番荔枝内酯,4-dexoxycherimolin-2(1),cherimolin-2(2),annoninI(3)和desacetyluvaricin(4)。其中1为新化合物。 相似文献
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斜脉暗罗素甲—具有C5—OH的单四氢呋喃环型番荔枝内酯 总被引:2,自引:0,他引:2
从斜脉暗罗(Polyalthia plagioneura Diels)的种子中分离到化合物P4 及P5,经IR、1H-NMR、13 C-NMR及MS谱鉴定,P4 为海南哥纳香甲素,P5 为具有C5-OH 的单四氢呋喃环型番荔枝内酯,命名为斜脉暗罗素甲(plagionicin A)。 相似文献
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大花哥纳香叶的化学成分 总被引:5,自引:0,他引:5
从番荔枝科哥纳香属植物大花哥纳香(Goniothalamusgriffithii)的叶中分离到4个化合物griffithineA(I),goniodiolmonoacetata(Ⅱ),β-sitosterol(Ⅳ)其中(I)为新化合物。 相似文献
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从景洪哥那香茎中得到3个具有抗癌活性和杀虫作用的番荔枝内醌化合物,goniothalamicin(1)cheliensisinB(2)〈CheliensisinC(3),其中2,3为新化合物。 相似文献
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刺果番荔枝种子中的新环肽—刺果番荔枝环肽A 总被引:3,自引:0,他引:3
从刺果番荔枝种子中得到1个新环肽,命名为刺果番荔枝环肽A(annomuricatinA)通过多种2D-NMR技术、pos.FAB-MS和氨基酸分析,其结构确定为坏(脯-苯丙-缬-丝-丙-甘),是1个环六肽。 相似文献
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刺果番荔枝中的番荔枝内酯(3) 总被引:1,自引:0,他引:1
刺果番荔枝中的番荔枝内酯(3)杨仁洲,吴淑君(中国科学院华南植物研究所,广州510650)关键词刺果番荔枝,番荔枝内酯ANNONACEOUSACETOGENINSFROMANNONAMURICATA(Ⅲ)¥YANGRen-Zhou;WUShu-Jun... 相似文献
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Crystal V, VI and VII were isolated from the seeds of Goniothalamus howii Merr. Et Chun. Based on the analysis of IR, 1H-NMR, 13C-NMR, MS and spectral analysis of their derivatives, they were identified as a new type of annonaceous acetogenins—seco-biste-trahydrofuran annonaceous acetogenins. V and VI were named as howiicin D and howiicin E, respectively. VII is a mixture of two compounds, named howiicins F and C, which have the same plane structure. 相似文献
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Compounds P4 and P5 had been isolated from the seeds of Polyalthia plagioneura Diels. The former was identified as howiicin A by the spectral analysis of [ α ]D, IR, 1 H - NMR, 13C-NMR and MS, the latter was characterized as a new monotetrahydrofuran annonaceous acetogenin with C5-OH, which was named plagionicin A. 相似文献
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Three rat BV13S1 alleles (T-cell receptor β-chain variable gene 13) were characterized by new BV13S1-allele specific monoclonal antibodies (18B1 and 17D5) and sequence analysis of expressed and genomic BV13S1. Two alleles were functional and designated BV13S1A1 present in strains LEW, BUF, PVG, and BV13S1A2 present in BN and WF. Their products differed by six amino acids, two of them in complementarity-determing region (CDR)1
and one in CDR2. A third nonfunctional allele, BV13S1A3P, was found in strains F344 and DA. Apart from a single nucleotide insertion, it was identical to BV13S1A2. All 12 rat strains tested showed association of TCRBC1 with BV8S2/4 alleles but not with the BV13S1 alleles, which may reflect a different gene order of the rat BV compared to mouse. BV13S1A1-encoded T-cell receptors (TCRs) which bind both monoclonal antibody (mAb) 18B1 and mAb 17D5 are over-represented in the CD4
lymphocyte subset. BV13S1A2-encoded TCRs which are stained by mAb 18B1 but not by mAb 17D5 show a slight CD8-biased expression. Preferential usage of
BV13S1A1-positive TCRs by CD4 but not by CD8 cells in (LEW×WF)F1 hybrids and cosegregation of BV13SA1 and increased frequency of BV13S1 TCR-positive CD4 cells in a (LEW×BN)×BN backcross suggest structural differences of the
two allelic products as the reason for their contrasting CD4/CD8 subset bias.
Received: 6 October 1999 / Revised: 25 November 1999 相似文献
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M A Duranti L Franzoni G Sartor A Benedetti L K Iwai A Gruber B Zingales F Guzman J Kalil A Spisni E Cunha-Neto 《Experimental parasitology》1999,93(1):38-44
The Trypanosoma cruzi recombinant protein B13 contains tandemly repeated domains and shows high sensitivity in the serological diagnosis of Chagas' disease. It has been shown that the immunodominant epitope of B13 is contained in the GDKPSLFGQAAAGDKPSLF-NH(2) sequence and that the hexapeptide AAAGDK seems to be the "core" of that epitope. Three peptides containing that "core" sequence, one corresponding to the entire repeat motif GDKPSLFGQAAAGDKPSLF-NH(2), pB13, and two smaller fragments, FGQAAAGDK-NH(2), S4, and QAAAGDKPS-NH(2), S5, have been tested in competitive ELISA with recombinant protein B13 in the solid phase against 40 chagasic sera from Brazilian patients. The median percentage inhibition for pB13, S4, and S5 were, respectively, 91, 86, and 68%. The possibility that the distinct antigenic activity of those peptides correlates with the existence of preferential conformational properties has been investigated by CD and NMR spectroscopy. Results indicate their propensity to adopt a helical configuration, centered in the AAAGDK sequence, and whose extent and stability directly correlates with the peptides' antigenicity. The data are discussed in the light of the existence of conformational preferences involving immunodominant epitopes in tandemly repeated antigens. 相似文献
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K.V. Honn K.K. Nelson C. Renaud R. Bazaz C.A. Diglio J. Timar 《Prostaglandins & other lipid mediators》1992,44(5)
Tumor cell interaction with the endothelium of the vessel wall is a rate limiting step in metastasis. The fatty acid modulation of this interaction was investigated in low (LM) and high (HM) metastatic B16 amelanotic melanoma (B16a) cells. 12(S)-HETE increased the adhesion of LM cells to endothelium derived from pulmonary microvessels. All other monohydroxy and dihydroxy fatty acids were ineffective. LTB4 induced a modest stimulation but LTC4, LTD4, LTE4 as well as LXA4 and LXB4 were ineffective. The 12(S)-HETE enhanced adhesion of B16a cells was inhibited by pretreatment with 13(S)-HODE but not by 13(R)-, 9(S)-HODE or 13-OXO-ODE. 13(S)-HODE decreased adhesion of HM B16a cells to endothelium. 12(S)-HETE enhanced surface expression of integrin αIIbβ3 and monoclonal antibodies against this integrin but not against α5β1, blocked enhanced but not basal adhesion to endothelium. Intravenous injection of 12(S)-HETE treated LM cells resulted in increased lung colonization (experimental metastasis). This effect was specific for 12(S)-HETE and was inhibited by 13(S)-HODE but not by other HODE's. 12(S)-HETE also enhanced lung colonization by HM cells and 13(S)-HODE decreased lung colonization by HM cells. Our results suggest a highly specific bidirectional modulation of metastatic phenotype and lung colonization by 12(S)-HETE and 13(S)-HODE. 相似文献
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Fatty acid modulation of tumor cell adhesion to microvessel endothelium and experimental metastasis. 总被引:4,自引:0,他引:4
Tumor cell interaction with the endothelium of the vessel wall is a rate limiting step in metastasis. The fatty acid modulation of this interaction was investigated in low (LM) and high (HM) metastatic B16 amelanotic melanoma (B16a) cells. 12(S)-HETE increased the adhesion of LM cells to endothelium derived from pulmonary microvessels. All other monohydroxy and dihydroxy fatty acids were ineffective. LTB4 induced a modest stimulation but LTC4, LTD4, LTE4 as well as LXA4 and LXB4 were ineffective. The 12(S)-HETE enhanced adhesion of B16a cells was inhibited by pretreatment with 13(S)-HODE but not by 13(R)-, 9(S)-HODE or 13-OXO-ODE. 13(S)-HODE decreased adhesion of HM B16a cells to endothelium. 12(S)-HETE enhanced surface expression of integrin alpha IIb beta 3 and monoclonal antibodies against this integrin but not against alpha 5 beta 1, blocked enhanced but not basal adhesion to endothelium. Intravenous injection of 12(S)-HETE treated LM cells resulted in increased lung colonization (experimental metastasis). This effect was specific for 12(S)-HETE and was inhibited by 13(S)-HODE but not by other HODE's. 12(S)-HETE also enhanced lung colonization by HM cells and 13(S)-HODE decreased lung colonization by HM cells. Our results suggest a highly specific bidirectional modulation of metastatic phenotype and lung colonization by 12(S)-HETE and 13(S)-HODE. 相似文献
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本文报道了对山楝Aphanamixis polystachya枝叶的化学成分进行研究。采用硅胶柱色谱、Sephadex LH-20、RP-C 18、HPLC等色谱分离手段,从其95%乙醇提取物中分离得到9个化合物,通过波谱方法进行鉴定为polystachyadione A(1)、polystachyadione B(2)、labd-13(E)-ene-8α,15-diol(3)、labd-13(E)-ene-8α,15-yl acetate(4)、1 S,4 S,5 S,10 R-4,10-愈创木二醇(5)、齐墩果酸(6)、3,4-二羟基苯甲酸(7)、反式咖啡酸(8)和单棕榈酸甘油酯(9)。其中化合物1和2为两个新化合物,化合物4、7、8和9为首次从该植物中分离得到。化合物1、2对脂多糖诱导的RAW 264.7细胞NO生成没有表现出明显的抑制作用。 相似文献
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