武陵山地区卵翅蝗属二新种：直翅目：斑腿蝗科

本文记述采自湖南湘西武陵山地区卵翅蝗属Ｃａｒｙａｎｄａ二新种,武陵山卵翅蝗Ｃａｒｙａｎｄａ ｗｕｌｉｎｇｓｈａｎａ ｓｐ．ｎｏｖ．和三齿卵翅蝗Ｃａｒｙａｎｄａ ｔｒｉｏｄｏｎｔａ ｓｐ．ｎｏｖ．。模式标本保存于陕西师范大学生物系。     

湖南省蝗虫一新属新种（蝗总科：斑腿蝗科）

本文记述在湖南省武陵山地区斑腿蝗科的新属拟稻蝗属Ｏｘｙｏｉｄｅｓ ｇｅｎ．ｎｏｖ．和武陵山拟稻蝗新种Ｏｘｙｏｉｄｅｓ ｗｕｌｉｎｇｓｈａｎｅｎｓｉｓ．ｓｐ．ｎｏｖ．。     

湖南武陵山地区小蹦蝗属一新种（直翅目：斑腿蝗科）

本文记述了采自湖南武陵山区的小蹦蝗属ＰｅｄｏｐｏｄｉｓｍａＺｈｅｎｇ一新种,小尾小蹦蝗Ｐ．ｆｕｒｃｕｌａｓｐ．ｎｏｖ该新种近似于秦岭小蹦蝗Ｐ．ｔｓｉｎｌｉｎｇｅｎｓｉｓ（Ｃｈｅｎｇ）。模式标本保存在陕西师范大学动物研究所蝗虫研究室。     

双宫带绦虫属属征修订及一新种记述(绦虫纲:圆叶目)

报道内蒙古草原中啮齿类绦虫一新种,即多枝双宫带绦虫,新种Ｄｉｕｔｅｒｉｍｏｔａｅｎｉｓ ｐｏｌｙｃｌａｄａ Ｙｕｎ ｅｔ Ｌｉｎ,ｓｐ．ｎｏｖ．,文中对新种的形态作了详细的描述,并与近似种进行比较,讨论了建新种的依据,对双宫带属的属征做了修订。     

中国闪蛛属一新种（蜘蛛目：跳蛛科）

本文报道采自我国武陵源的闪蛛属一新种,武陵闪蛛Ｈｅｌｉｏｐｈａｎｕｓ ｗｕｌｉｎｇｅｎｓｉｓ ｓｐ．ｎｏｖ．,绘有外形及生殖器结构图。模式标本保存于湖南省生物研究所。     

膜壳绦虫属二新种(绦虫纲:圆叶目:膜壳科)

本文记述膜壳科膜壳属绦虫二新种,即卷尾膜壳绦虫Ｈｙｍｅｎｏｌｅｐｉｓ ｃｈｉｂｉａｅ ｓｐ．ｎｏｖ．和三宝鸟膜壳绦虫Ｈ．ａｂｕｎｄｕｓ ｓｐ．ｎｏｖ．卷尾膜壳绦虫标本采自福州的黑发冠卷属Ｃｈｉｂｉａ Ｈｏｔｔｅｎｔｏｔｔａ Ｂｒｅｖｉｒｏｓｔｒｉｓ;三宝鸟膜壳绦虫标本采自福州的三宝鸟Ｅｕｒｙｓｔ９ｏｍｕｓ ｏｒｉｅｎｔａｌｉｓ ａｂｕｎｄｕｓ均为肠道寄生虫。     

萤叶甲亚科研究Ⅰ．阿波萤叶甲属的补充描记及二新种记述（鞘翅目：叶甲科）

本文对阿波萤叶甲属Ａｐｌｏｓｏｎｙｘ的属征作了补充描记,并记述了采自我国武陵山区的二新种,黑头阿波萤叶甲Ａ．ｎｉｇｒｉｃｅｐｓｓｐ．ｎｏｖ．及天平山阿波萤叶甲Ａ．ｔｉａｎｐｉｎｇｓｈａｎｅｎｓｉｓｓｐ．ｎｏｖ．。     

武陵山地区鱼类寄生杆咽属线虫两新种

本文报道在武陵山地区的白甲鱼［（Ｖａｒｉｃｏｒｋｉｎｕｓ（Ｏｎｙｃｈｏｓｔｏｍａ）ｓｉｍｕｓ（ＳａｕｖａｇｅｅｔＤａｂｒｙ）］和沪溪直口峻（ＲｅｃｔｏｒｉｓｌｕｘｉｅｎｓｉｓＷｕｅｔＹａｏ）中发现的两种杆咽属（Ｒｈａｂｄｏｃｈｏｎａ）线虫新种,定名为白甲鱼杆咽线虫,新种（ＲｈａｂｄＯｃｈｏｎａｏｎｙｒｋｏｓｔｏｍｉｓｐ．ｎｏｖ．）和短咽杆咽线虫,新种（ＲｈａｂｄＯｃｈｏｎａｂｒｅｖｉｃｈｏｎａｓｐ．ｎｏｖ．）,并对两新种进行了测量和详细的描述。     

四川西部云南鳅属鱼类一新种记述：鲤形目：鳅科

本文报道产于四川西部安宁河（属雅砻江支流）的云南鳅属Ｙｕｎｎａｎｉｌｕｓ鱼类一新种,命名为四川云南鳅,新种Ｙ．ｓｉｃｈｕａｎｅｎｓｉｓｓｐ．ｎｏｖ．,详细葶了新种的形态特征,并与近似种进行了比较。     

鱼类寄生毛细科线虫－新属新种的研究

作者在武陵山地区的鱼类寄生线虫调查工作中,发现一种毛细线虫,经研究,为一新种,定名为岁新毛细线虫,新种（Ｎｅｏｃａｐｉｌｌａｒｉａｐｈｏｘｉｎｉｓｐ．ｎｏｖ．）。根据其特征,为此建立一新属──新毛细线虫属。     

Recent advances in the study of Kaposi's sarcoma-associated herpesvirus replication and pathogenesis

It has now been over twenty years since a novel herpesviral genome was identified in Kaposi's sarcoma biopsies. Since then, the cumulative research effort by molecular biologists, virologists, clinicians, and epidemiologists alike has led to the extensive characterization of this tumor virus, Kaposi's sarcoma-associated herpesvirus(KSHV; also known as human herpesvirus 8(HHV-8)), and its associated diseases. Here we review the current knowledge of KSHV biology and pathogenesis, with a particular emphasis on new and exciting advances in the field of epigenetics. We also discuss the development and practicality of various cell culture and animal model systems to study KSHV replication and pathogenesis.     

A Unique Protease Cleavage Site Predicted in the Spike Protein of the Novel Pneumonia Coronavirus (2019-nCoV) Potentially Related to Viral Transmissibility

正Dear Editor,In December 2019, a novel human coronavirus caused an epidemic of severe pneumonia(Coronavirus Disease 2019,COVID-19) in Wuhan, Hubei, China(Wu et al. 2020; Zhu et al. 2020). So far, this virus has spread to all areas of China and even to other countries. The epidemic has caused 67,102 confirmed infections with 1526 fatal cases     

Curcuminoids as inhibitors of thioredoxin reductase: A receptor based pharmacophore study with distance mapping of the active site

Curcumin is the yellow pigment of turmeric that interacts irreversibly forming an adduct with thioredoxin reductase (TrxR), an enzyme responsible for redox control of cell and defence against oxidative stress. Docking at both the active sites of TrxR was performed to compare the potency of three naturally occurring curcuminoids, namely curcumin, demethoxy curcumin and bis-demethoxy curcumin. Results show that active sites of TrxR occur at the junction of E and F chains. Volume and area of both cavities is predicted. It has been concluded by distance mapping of the most active conformations that Se atom of catalytic residue SeCYS498, is at a distance of 3.56 from C13 of demethoxy curcumin at the E chain active site, whereas C13 carbon atom forms adduct with Se atom of SeCys 498. We report that at least one methoxy group in curcuminoids is necessary for interation with catalytic residues of thioredoxin. Pharmacophore of both active sites of the TrxR receptor for curcumin and demethoxy curcumin molecules has been drawn and proposed for design and synthesis of most probable potent antiproliferative synthetic drugs.     

Synthesis and antimicrobial studies of hydrazone derivatives of 4-[3-(2,4-difluorophenyl)-4-formyl-1H-pyrazol-1-yl]benzoic acid and 4-[3-(3,4-difluorophenyl)-4-formyl-1H-pyrazol-1-yl]benzoic acid

Microbial resistance to antibiotics is an unresolved global concern, which needs urgent and coordinated action. One of the guidelines of the Centers for Disease Control and Preventions (CDC) to combat antibiotic resistance is the development of new antibiotics to treat drug-resistant bacteria. In our effort to find new antibiotics, we report the synthesis and antimicrobial studies of 30 new pyrazole derivatives. These novel molecules have been synthesized by using readily available starting materials and benign reaction conditions. Some of these molecules have shown activity with MIC values as low as 0.78?µg/mL against four bacterial strains; Staphylococcus aureus, methicillin-resistant S. aureus, Bacillus subtilis, and Acinetobacter baumannii. Furthermore, active molecules are non-toxic to mammalian cell line.

     

Comparative morphology of the carpel in the Liliaceae: Hewardieae, Petrosavieae, and Tricyrteae

The young pistils in the melanthioid tribes, Hewardieae, Petrosavieae and Tricyrteae, are uniformly tricarpellate and syncarpous. They lack raphide idioblasts. All are multiovulate, with bitegmic ovules. The Petrosavieae are marked by the presence of septal glands and incomplete syncarpy. Tepals and stamens adhere to the ovary in the Hewardieae and the Petrosavieae but not in the Tricyrteae. Two vascular bundles occur in the stamens of the Hewartlieae and Tricyrtis latifolia. Ventral bundles in the upper part of the ovary of the Hewardieae are continuous with compound septal bundles and placental bundles in the lower part. Putative ventral bundles occur in the alternate position in the Tricyrteae and putative placental bundles in the opposite. position in the Petrosavieae. The dichtomously branched stigma in each carpel of the Tricyrteae is supplied by a bifurcated dorsal bundle.     

Novel compounds with potent CDK9 inhibitory activity for the treatment of myeloma

Cyclin-dependent kinases (CDKs) and Polo-like kinases (PLKs) play key role in the regulation of the cell cycle. The aim of our study was originally the further development of our recently discovered polo-like kinase 1 (PLK1) inhibitors. A series of new 2,4-disubstituted pyrimidine derivatives were synthesized around the original hit, but their PLK1 inhibitory activity was very poor. However the novel compounds showed nanomolar CDK9 inhibitory activity and very good antiproliferative effect on multiple myeloma cell lines (RPMI-8226).