云南“本人”的红细胞血型分布及其与契丹人血缘关系的探讨

调查了云南省施甸县木老元乡哈寨村１０４名“本人”的４个细胞血型系统分布。结果表明,“本人”的ＡＢＯ血型系统分布特点是,基因频率ｐ（０．３０６９）〉基因频率ｑ（０．１７３９）;在ＭＮＳｓ血型系统中,基因频率ｍ（０．６５３８）〉基因频率ｎ（０．３４６２）;在Ｐ血型系统中,基因频率Ｐ１（０．１７９８）较低。这些均与我国南方少数民族的分布特点基本相符。与我国大部分地区一样。Ｒｈ因型系统的单倍型频率中最高的     

24种红细胞血型抗原在黑龙江省赫哲族人群中的分布

对３代均为赫哲族的黑龙江省同江县街津口乡和八叉乡的９４人进行了１０个红细胞血型系统（ＡＢＯ、Ｒｈ、ＭＮＳｓ、Ｄｕｆｆｙ、Ｋｉｄｄ、Ｌｕｔｈｅｒａｎ、Ｄｉｅｇｏ、Ｐ、Ｋｅｌｌ、Ｌｅｗｉｓ）共２３种抗原分布的调查,结果显示,基因频率ｑ（０．２２２３）〉ｐ（０．１６９２）,ｍ（０．６０１１）〉ｎ（０．３９８９）,为我国北方人群特点。其它基因频率为,ｒ＝０．６０８５;Ｓ＝０．０６９１,ｓ＝０．９３０９,Ｍ     

安徽省宁国县畲族红细胞血型分布

调查１６０名安徽省宁国县畲族村民的ＡＢＯ、Ｒｈ、Ｐ、ＭＮ系统红细胞血型,结果显示ＡＢＯ血型表型频率分布为Ｏ（０．４６８７）〉Ｂ（０．２３７５）〉Ａ（０．２２５０）〉ＡＢ（０．０６８８）,基因频率ｐ＝０．１５００,ｑ＝０．１５７５,ｒ＝０．６９２５;Ｒｈ血型表型频率分布为ＣＣｄｅｅ（０．５３８５）〉ＣＣＤＥ（０．１６６７）〉ＣｃＤＥ（０．１４７４）〉ＣｃＤｅｅ（０．０９６１）〉ｃｃＤＥ（０．０３２１     

云南阿昌族的红细胞血型分布

调查了１０２名云南阿昌族的ＡＢＯ,ＮＮＳｓ,Ｒｈ和Ｐ系统的红细胞血型,结果表明,阿昌族的基因频率ｐ（０．３８７４）是迄今国内调查过人群中的最高值,Ｅ（０．２４５９）和ＣＤｅ（０．６９３６）基因或染色体频率较高,而Ｓ（０．０６８６）和Ｐ１（０．１０８９）频率较低;Ｍｓ（０．５９５０）连锁率高于Ｎｓ（０．３３５３）;未发现ＳＳ和Ｒｈ（－Ｄ）阴性表现型。     

刺槐宽叶和四倍体无性系的组织培养

１植物名称刺槐（Ｒｏｂｉｎｉａｐｓｅｕｄｏａｃａｃｉａ）优良无性系：Ｔｅｔｒａｐｌｏｉｄｌｏｃｕｓｔ、Ｇｌｇａｓｔｙｐｅｌｏｃｕｓｔ。２材料类别带腋芽的茎段。３培养条件（１）启动培养基：ＭＳ＋６－ＢＡ０．２５ｍｇ·Ｌ－１（单位下同）＋ＮＡＡ０．０５。（２）分化培养基和继代培养基：ＭＳ＋６－ＢＡ０．５＋ＮＡＡ０．１＋ＡｇＮＯ３１０,ＭＳ＋６ＢＡ０．５＋ＮＡＡ０．１。上述培养基均添加３％蔗糖、０．６％琼脂。（３）生根培养基：１／２ＭＳ＋ＩＢＡ０．２＋ＮＡＡ０．２,添加２％蔗糖０．６％琼脂。培养基ｐＨ…     

内蒙地区九个民族的ABO血型分布

本文报告了９个民族ＡＢＯ血型分布,特征有三种：汉族和回族为Ｂ＞Ｏ＞Ａ;达斡尔族为Ｂ＞Ａ＞Ｏ;其余民族（蒙、鄂温克、朝鲜、满族、俄罗斯、鄂伦春族）为Ｏ＞Ｂ＞Ａ,基因频率ｒ（Ｏ）：鄂温克（０．７５４９）较高,达斡尔（０．５２３４）和回族（０．５１７１）较低。Ｐ（Ａ）：鄂温克（０．１１３８）偏低,朝鲜族（０．２２７７）和达斡尔族（０．２２５３）偏高。ｑ（Ｂ）：回族（０．２８１８）略高,鄂温（０．１３１３     

GENUS ANTROPHYUM KAULF.FROM CHINA AND NEIGHBORING REGIONS

ＧＥＮＵＳＡＮＴＲＯＰＨＹＵＭＫＡＵＬＦ．ＦＲＯＭＣＨＩＮＡＡＮＤＮＥＩＧＨＢＯＲＩＮＧＲＥＧＩＯＮＳＸ．Ｃ．ＺＨＡＮＧ（Ｔｈｅｈｅｒｂａｒｉｕｍ（ＰＥ）,ＩｎｓｔｉｔｕｔｅｏｆＢｏｔａｎｙ,ＣｈｉｎｅｓｅＡｃａｄｅｍｙｏｆＳｃｉｅｎｃｅｓ,Ｂｅｉ...     

酸枣的组织培养和植株再生

１植物名称酸枣（Ｚｉｚｙｐｈｕｓ　ｊｕｊｕｂａｖａｒ．Ｓｐｉｎｏｓａ）。２材料类别沂河岸堤自然生长的野生植株上的嫩芽。３培养条件诱导愈伤组织培养基：（１）ＭＳ＋６－ＢＡ２ｍｇ·Ｌ’（单位下同）＋ＮＡＡ０．１;（２）ＭＳ＋６－ＢＡ２＋ＮＡＡ０．２;（３）ＭＳ＋６．ＢＡ２＋ＮＡＡ０．４;（４）ＭＳ＋６．ＢＡ２＋ＮＡＡ１;（５）ＭＳ＋６．ＢＡ２＋ＮＡＡ０．０１;（６）ＭＳ＋６．ＢＡ２＋ＮＡＡ０．０５;（７）ＭＳ＋６－ＢＡＩ＋ＮＡＡ０．５。芽分化培养基：（８）ＭＳ＋６－ＢＡＩ;（９）ＭＳ＋６－ＢＡ２;（…     

云南省峨山县彝族人群红细胞ABO血型分布调查

本文报告了云南省峨山县彝族红细胞ＡＢＯ血型基因频率分布状况,有以下特征：表型Ｏ＞Ａ＞Ｂ＞ＡＢ;基因频率Ｙ＝０．５６７９、Ｐ＝０．２３０９、ｑ＝０．２０１２;ＤＰ值为０．７１８７,文中对红细胞ＡＢＯ血型在不同人群中的分布进行了比较分析。１材料和方法样品...     

硫代磷酸反义寡脱氧核苷酸抗HBV细胞的实验研究

针对ＨＢＶ的５个基因位点作为靶序列,设计合成硫代反义寡聚核苷酸（Ｓ－ａｓＯＤＮ）．应用ＥＬＩＳＡ方法、ＭＴＴ比色法、电子显微镜等手段,观察Ｓ－ａｓＯＤＮ对ＨｅｐＧ２２２１５细胞ＨＢｓＡｇ、ＨＢｅＡｇ抗原的表达,及细胞的毒性、细胞形态和超微结构的影响．结果显示不同靶位点的Ｓ－ａｓＯＤＮ对ＨＢｓＡｇ、ＨＢｅＡｇ表达都有显著的抑制作用,且表现为序列特异性、剂量相关性、联合协同性和一定的抗核酸酶性,在浓度为２０μｍｏｌ／Ｌ时,对细胞无明显杀伤作用,对细胞的超微结构无显著的改变．结果提示Ｓ－ａｓＯＤＮ有望发展为抗ＨＢＶ的有效药物,但靶序列的选择、透细胞膜性及联合用药配伍等仍值得进一步研究和解决．     

Recent advances in the study of Kaposi's sarcoma-associated herpesvirus replication and pathogenesis

It has now been over twenty years since a novel herpesviral genome was identified in Kaposi's sarcoma biopsies. Since then, the cumulative research effort by molecular biologists, virologists, clinicians, and epidemiologists alike has led to the extensive characterization of this tumor virus, Kaposi's sarcoma-associated herpesvirus(KSHV; also known as human herpesvirus 8(HHV-8)), and its associated diseases. Here we review the current knowledge of KSHV biology and pathogenesis, with a particular emphasis on new and exciting advances in the field of epigenetics. We also discuss the development and practicality of various cell culture and animal model systems to study KSHV replication and pathogenesis.     

A Unique Protease Cleavage Site Predicted in the Spike Protein of the Novel Pneumonia Coronavirus (2019-nCoV) Potentially Related to Viral Transmissibility

正Dear Editor,In December 2019, a novel human coronavirus caused an epidemic of severe pneumonia(Coronavirus Disease 2019,COVID-19) in Wuhan, Hubei, China(Wu et al. 2020; Zhu et al. 2020). So far, this virus has spread to all areas of China and even to other countries. The epidemic has caused 67,102 confirmed infections with 1526 fatal cases     

Curcuminoids as inhibitors of thioredoxin reductase: A receptor based pharmacophore study with distance mapping of the active site

Curcumin is the yellow pigment of turmeric that interacts irreversibly forming an adduct with thioredoxin reductase (TrxR), an enzyme responsible for redox control of cell and defence against oxidative stress. Docking at both the active sites of TrxR was performed to compare the potency of three naturally occurring curcuminoids, namely curcumin, demethoxy curcumin and bis-demethoxy curcumin. Results show that active sites of TrxR occur at the junction of E and F chains. Volume and area of both cavities is predicted. It has been concluded by distance mapping of the most active conformations that Se atom of catalytic residue SeCYS498, is at a distance of 3.56 from C13 of demethoxy curcumin at the E chain active site, whereas C13 carbon atom forms adduct with Se atom of SeCys 498. We report that at least one methoxy group in curcuminoids is necessary for interation with catalytic residues of thioredoxin. Pharmacophore of both active sites of the TrxR receptor for curcumin and demethoxy curcumin molecules has been drawn and proposed for design and synthesis of most probable potent antiproliferative synthetic drugs.     

The structure, reproduction and taxonomy of Vidalia and Osmundaria (Rhodophyta, Rhodomelaceae)

Comprises species occurring mostly in subtidal habitats in tropical, subtropical and warm-temperate areas of the world. An analysis of the type species, V. spiralis (Sonder) Lamouroux ex J. Agardh, a species from Australia, establishes basic characters for distinguishing species in the genus. These characters are (1) branching patterns of thalli, (2) flat blades that may be spiralled on their axis, (3) width of the blade, (4) primary or secondary derivation of sterile and fertile branchlets and (5) position of sterile and fertile branchlets on the thalli. Application of the latter two characters provides an important basic method for separation of species into three major groups. Osmundaria , a genus known only in southern Australia, was studied in relation to Vidalia , and its separation from the Vidalia assemblage is not accepted. Species of Vidalia therefore are transferred to the older genus name, Osmundaria. Two new species, Osmundaria papenfussii and Osmundaria oliveae are described from Natal. Confusion in the usage of the epithet, Vidalia fimbriala Brown ex Turner has been clarified, and Vidalia gregaria Falkenberg, described as an epiphyte on Osmundaria pro/ifera Lamouroux, is revealed to be young branches of the host, Osmundaria prolifera.     

New or rare chromosome counts in Artemisia L. (Asteraceae, Anthemideae) and related genera from Kazakhstan

Fifteen chromosome counts of six Artemisia taxa and one species of each of the genera Brachanthemum, Hippolytia, Kaschgaria, Lepidolopsis and Turaniphytum are reported from Kazakhstan. Three of them are new reports, two are not consistent with previous counts and the remainder are confirmations of very scarce (one to four) earlier records. All the populations studied have the same basic chromosome number, x = 9, with ploidy levels ranging from 2x to 6x. Some correlations between ploidy level, morphological characters and distribution are noted.