微生物学全英文教学的意义、问题以及促研促教的实践探索北大核心CSCD

微生物涉及人类生活的方方面面,微生物学是各类高校为生命科学、医学、药学、农业、林业、食品等有关专业开设的本科生必修专业基础课。在国际化和一流学科发展趋势下,全英文授课具有重要意义并越来越受到重视。本文旨在探讨在如今面向人类生命健康、强调学科交叉的时代,如何结合本学校专业优势,开展微生物学英文教学的课程改革,将微生物学与医药、农业、环境、健康等充分结合,力争做到以学促研、以学促教,打造出具有本学校特色的微生物学全英文课程,将有关实践探索与微生物学教学工作者进行交流。     

组织学与胚胎学全英语教学实践

顺应医学教育国际化趋势,我们进行组织学与胚胎学全英文教学实践活动已有八年。作为一门医学基础课程,组织学与胚胎学全英文教学改革之初也遇到教材、师资、授课方法等诸多困难,通过学校的政策扶持以及教研室全体教师的努力,目前组织学与胚胎学全英文课程教学体系已日趋完善、成熟,在教学内容、教学方法、教材编写、师资建设等方面取得了长足的进步,为医学生进行后续全英文课程的学习打下坚实的基础。     

青年教师提高医学微生物学教学质量的体会

医学微生物学是一门重要的医学基础课程,具有知识点繁多、内容分散的特点。拥有高学历的青年教师正逐步成为高等院校的主力军,提高青年教师医学微生物学教学质量是亟待解决的重要问题。本文从夯实教学基本功、提升教学能力、灵活运用多种教学方法和数字化教学手段、处理教学与科研的关系等多个方面,对如何提高青年教师医学微生物学教学质量进行了探讨。     

针对留学生的医学微生物学教学体会与探讨

医学微生物学是医学院校各专业的一门重要基础课程,也是一门较难讲解的课程,针对留学生尤为如此。针对我校留学生在医学微生物学教学中出现的问题,在如何克服语言障碍、选择教材和教学内容、优化教学方法与手段、严格教学管理和考核制度等方面我们做了诸多尝试,现将我们的一些体会和经验与各位同仁共同探讨,以期提高留学生医学微生物学教学水平。     

生物专业大学生如何学好《微生物学》这门课

《微生物学》是研究微生物在一定外界环境条件影响下的形态结构、生理生化、遗传变异以及微生物的进化、分类、生态等生命活动规律及其应用技术的一门科学。在理工科类大学生物专业中 ,属专业基础课 ,无论是本科学生 ,还是专科学生 ,都是一门非常重要的课程。我校自开办生物专业以来 ,即把这门课作为生物专业的重要必修课而重点建设。经过几年的教学实践 ,笔者深切感到微生物学课程教学与其它课程具有不同的特点 ,为了有效提高学生的学习效果 ,特提出几点教学体会 ,供学生学习时参考借鉴。1　充分认识微生物学课程的重要性、树立专业思想人…     

高职教育食品微生物学教学改革初探

在高职教育中,食品微生物学是一门涉及范围广、涉及学科多、实践性很强、以与食品有关的微生物为主要研究对象的学科。根据食品微生物学课程的总体教学目标要求,结合当前该门课程在教学中存在的诸多问题,提出教学改革问题,以有效的提高食品微生物学课程的教学质量。     

“微生物学”全英文课程的建设改革与思考

“微生物学”是高等院校生物类、生物工程类及相关专业的专业基础课程。目前我国高等院校的“微生物学”以中文授课为主,但随着“双一流”建设等教改政策的推进及学生求学多元化需求的增加,全英文“微生物学”课程建设已势在必行。华东理工大学自2016年即开始“微生物学”全英文授课,并在授课方式和课程内容方面进行了改革和创新。“微生物学”全英文课程开设后,学生的学习兴趣有了很大的提高,科研能力和实践能力有了长足的进步,在专业英语的听、说、读、写能力方面也领先于同年级其他同学,为“双一流”建设背景下国家级一流本科专业创新性人才培养提供了重要支撑。     

北京大学微生物学实验课模块化教学的探索

微生物学是一门重要的生命科学分支学科,并在很大程度上促进了其他分支学科如分子生物学等的发展。在北京大学新的教学体系下,微生物学实验课被提前到大学一年级本科生选修。为了保证一年级本科生能够掌握微生物学基础实验技术,达到良好的学习效果,作者在参考了国内各综合性大学所编写的微生物学基础实验教材之后,认真梳理了教材中相关微生物学基础实验,明确了微生物基础实验课的教学要求和目的:学生能掌握微生物学基础实验技术并能初步运用这些技术解决实际问题。根据新体系中教学目的,作者重新设计和丰富了微生物基础实验内容,进行了模块化教学的实验教学安排,增强了课程的整体性、连贯性、实用性和开放性,提高了学生学习的兴趣,实现了教学目的。     

微生物学教学拾零

近年来在从事中药系的微生物学教学中,对微生物学的时数,该课程的教学和教材诸问题有一点感受,现谈一点肤浅意见,与同行探讨,以便进一步提高微生物学的教学。一、中药系微生物学课程的时数问题中药系的微生物学既要为中药学、药剂学、炮制学、药理学打下基础;又要用微生物学的技术与手段去解决中草药及其制剂中的质量问题。从某种意义上来看该系的微生物学是一门     

新时代人才培养需求下工科高校专业课教学创新与实践：以“环境工程微生物学”为例

“环境工程微生物学”是传统工科高校环境类专业的前置核心专业必修课程,为满足新时代下新的人才培养需求,我们教学团队聚焦课程教学中存在的四大痛点问题,通过教学内容、教学方法、评价方式、思政融入四大环节对“环境工程微生物学”课程教学进行教学改革。经多轮成果应用与迭代以及多方教学评价,结果表明该课程的教学改革显著提升了课程的教学质量。     

A Unique Protease Cleavage Site Predicted in the Spike Protein of the Novel Pneumonia Coronavirus (2019-nCoV) Potentially Related to Viral Transmissibility

正Dear Editor,In December 2019, a novel human coronavirus caused an epidemic of severe pneumonia(Coronavirus Disease 2019,COVID-19) in Wuhan, Hubei, China(Wu et al. 2020; Zhu et al. 2020). So far, this virus has spread to all areas of China and even to other countries. The epidemic has caused 67,102 confirmed infections with 1526 fatal cases     

Curcuminoids as inhibitors of thioredoxin reductase: A receptor based pharmacophore study with distance mapping of the active site

Curcumin is the yellow pigment of turmeric that interacts irreversibly forming an adduct with thioredoxin reductase (TrxR), an enzyme responsible for redox control of cell and defence against oxidative stress. Docking at both the active sites of TrxR was performed to compare the potency of three naturally occurring curcuminoids, namely curcumin, demethoxy curcumin and bis-demethoxy curcumin. Results show that active sites of TrxR occur at the junction of E and F chains. Volume and area of both cavities is predicted. It has been concluded by distance mapping of the most active conformations that Se atom of catalytic residue SeCYS498, is at a distance of 3.56 from C13 of demethoxy curcumin at the E chain active site, whereas C13 carbon atom forms adduct with Se atom of SeCys 498. We report that at least one methoxy group in curcuminoids is necessary for interation with catalytic residues of thioredoxin. Pharmacophore of both active sites of the TrxR receptor for curcumin and demethoxy curcumin molecules has been drawn and proposed for design and synthesis of most probable potent antiproliferative synthetic drugs.     

The structure, reproduction and taxonomy of Vidalia and Osmundaria (Rhodophyta, Rhodomelaceae)

Comprises species occurring mostly in subtidal habitats in tropical, subtropical and warm-temperate areas of the world. An analysis of the type species, V. spiralis (Sonder) Lamouroux ex J. Agardh, a species from Australia, establishes basic characters for distinguishing species in the genus. These characters are (1) branching patterns of thalli, (2) flat blades that may be spiralled on their axis, (3) width of the blade, (4) primary or secondary derivation of sterile and fertile branchlets and (5) position of sterile and fertile branchlets on the thalli. Application of the latter two characters provides an important basic method for separation of species into three major groups. Osmundaria , a genus known only in southern Australia, was studied in relation to Vidalia , and its separation from the Vidalia assemblage is not accepted. Species of Vidalia therefore are transferred to the older genus name, Osmundaria. Two new species, Osmundaria papenfussii and Osmundaria oliveae are described from Natal. Confusion in the usage of the epithet, Vidalia fimbriala Brown ex Turner has been clarified, and Vidalia gregaria Falkenberg, described as an epiphyte on Osmundaria pro/ifera Lamouroux, is revealed to be young branches of the host, Osmundaria prolifera.     

New or rare chromosome counts in Artemisia L. (Asteraceae, Anthemideae) and related genera from Kazakhstan

Fifteen chromosome counts of six Artemisia taxa and one species of each of the genera Brachanthemum, Hippolytia, Kaschgaria, Lepidolopsis and Turaniphytum are reported from Kazakhstan. Three of them are new reports, two are not consistent with previous counts and the remainder are confirmations of very scarce (one to four) earlier records. All the populations studied have the same basic chromosome number, x = 9, with ploidy levels ranging from 2x to 6x. Some correlations between ploidy level, morphological characters and distribution are noted.     

Comparative morphology of the carpel in the Liliaceae: Hewardieae, Petrosavieae, and Tricyrteae

The young pistils in the melanthioid tribes, Hewardieae, Petrosavieae and Tricyrteae, are uniformly tricarpellate and syncarpous. They lack raphide idioblasts. All are multiovulate, with bitegmic ovules. The Petrosavieae are marked by the presence of septal glands and incomplete syncarpy. Tepals and stamens adhere to the ovary in the Hewardieae and the Petrosavieae but not in the Tricyrteae. Two vascular bundles occur in the stamens of the Hewartlieae and Tricyrtis latifolia. Ventral bundles in the upper part of the ovary of the Hewardieae are continuous with compound septal bundles and placental bundles in the lower part. Putative ventral bundles occur in the alternate position in the Tricyrteae and putative placental bundles in the opposite. position in the Petrosavieae. The dichtomously branched stigma in each carpel of the Tricyrteae is supplied by a bifurcated dorsal bundle.     

肝癌中HBV和HCV基因和抗原的分布及意义

采用原位分子杂交方法检测HCV RNA及HBV X基因;采用免疫组织化学方法研究HCV核心抗原,非结构区C33c抗原及HBxAg在肝细胞肝癌中的定位及分布.结果表明(1)HCV RNA、HBV X基因在肝细胞肝癌组织检出率分别为40%(55/136)和82%(112/136).HCV RNA定位于癌细胞的胞浆内,阳性细胞呈散在、灶状及弥漫分布三种形式;HBV X基因在肝癌细胞中的分布呈胞浆型、核型及核浆型,阳性细胞也呈上述三种分布形式;(2)HCV C33c抗原、核心抗原在肝细胞肝癌中的阳性率为81%(133/164)及86%(141/164).C33c抗原定位于癌细胞及肝细胞的胞浆内;核心抗原既定位于癌细胞核中,又可定位于胞浆中.C33c抗原阳性细胞以灶状分布为主;而核心抗原阳性细