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Xiao‐Juan Yu Xiao‐Ren Peng Tong‐Huan Li 《Journal of cellular and molecular medicine》2014,18(12):2530-2535
Many studies have examined the association between the FABP2 (rs1799883) Ala54Thr gene polymorphism and type 2 diabetes mellitus risk (T2DM) in various populations, but their results have been inconsistent. To assess this relationship more precisely, A HuGE review and meta‐analysis were performed. The PubMed and CNKI database was searched for case‐control studies published up to April 2014. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated. Ultimately, 13 studies, comprising 2020 T2DM cases and 2910 controls were included. Overall, for the Thr carriers (Ala/Thr and Thr/Thr) versus the wild‐type homozygotes (Ala/Ala), the pooled OR was 1.18 (95% CI = 1.04–1.34, P = 0.062 for heterogeneity), for Thr/Thr versus Ala/Ala the pooled OR was 1.17 (95% CI = 1.05–1.41 P = 0.087 for heterogeneity). In the stratified analysis by ethnicity, the significantly risks were found among Asians but not Caucasians. This meta‐analysis suggests that the FABP2 (rs1799883) Ala54Thr polymorphisms are associated with increased susceptibility to T2DM risk among Asians but not Caucasians. 相似文献
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Plant and Soil - To investigate the effects of polystyrene microplastics (PS-beads) on the soil properties, photosynthesis of Flowering Chinese cabbage, the rhizosphere microbial community and... 相似文献
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<正>Aristolochic acids, mutational signature, and hepatocellular carcinoma Aristolochic acids (AA) are the etiologic agents of aristolochic acid nephropathy (AAN) and contribute to the global prevalence of chronic kidney disease and urothelial cancer (Grollman et al., 2007). DNA adducts formed by AA generate a unique AT transversions mutation spectrum at 相似文献
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城市景观生态风险评估框架与实践——以北京天坛地区为例 总被引:3,自引:0,他引:3
当前,城市景观生态风险研究缺少科学合理、方便实用的评估框架。作者基于景观生态风险评估基本范式,明确了城市景观生态服务价值的测算方法,分析了引起生态损害的自然因素和人类活动因素,形成了城市景观生态风险评估的技术框架和参数体系;继而以北京天坛地区为研究区,开展了典型城市景观生态风险的定量评估。结果表明:(1)天坛地区景观生态价值总量约为2.41亿元。区域的历史文化价值最高,教育和美学景观价值紧随其后。(2)城市景观生态受损概率呈现"北高南低"的空间分布格局。生态受损概率的高值区面积占整个区域总面积的22.2%,主要分布在珠市口、磁器口和崇文门附近区域。(3)城市景观生态风险呈现"北低南高"的空间分布格局。高风险区主要分布在天坛公园内的文物建筑周边。本研究提供了一个可参考的城市景观生态风险评估应用框架,对生态风险评估中的不确定性进行了讨论,研究针对天坛案例区的具体结论有助于城市管理者避免潜在的风险。 相似文献
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Xu Liu Ben Chen Lulan Chen Wan-Ting Ren Juan Liu Guoxiang Wang Wei Fan Xin Wang Yun Wang 《PloS one》2013,8(4)
Phenol red is widely used in cell culture as a pH indicator. Recently, it also has been reported to have estrogen-like bioactivity and be capable of promoting cell proliferation in different cell lines. However, the effect of phenol red on primary neuronal culture has never been investigated. By using patch clamp technique, we demonstrated that hippocampal pyramidal neurons cultured in neurobasal medium containing no phenol red had large depolarization-associated epileptiform bursting activities, which were rarely seen in neurons cultured in phenol red-containing medium. Further experiment data indicate that the suppressive effect of the phenol red on the abnormal epileptiform burst neuronal activities was U-shape dose related, with the most effective concentration at 28 µM. In addition, this concentration related inhibitory effect of phenol red on the epileptiform neuronal discharges was mimicked by 17-β-estradiol, an estrogen receptor agonist, and inhibited by ICI-182,780, an estrogen receptor antagonist. Our results suggest that estrogen receptor activation by phenol red in the culture medium prevents formation of abnormal, epileptiform burst activity. These studies highlight the importance of phenol red as estrogen receptor stimulator and cautions of careful use of phenol red in cell culture media. 相似文献
10.
Soil and climate are major constituents of the French notion of Terroir. This concept implies that there is a strong relationship
between the composition of the grape, the characteristics of the wine and the territory of production. To study this link,
a new method of characterization of the Terroir, including geological and pedological factors, was investigated. It uses a
field model based on depth and clay content of soil, together with the degree of weathering of the parent rock. Consequently,
for every type of parent rock belonging to a given geologic stage, there are a series of soils that show different stages
of pedological evolution. According to the model, three kinds of soils are distinguished with regards to the weathering intensity
of the parent rock, that are named weakly weathered rock (WWR), moderately weathered rock (MWR) and strongly weathered rock
(SWR). By hypothesis, each soil type is considered as a homogeneous unit for vine production from the viewpoint of ecophysiological
factors. Each terroir unit defined by this method is called a Basic Terroir Unit (BTU). To validate this hypothesis, experimental
plots planted with Chenin and Cabernet Franc vines were studied over three consecutive seasons (2000–2002), in the Anjou vineyard
(Loire Valley – France). The major BTUs developed on the two most important geological systems of Anjou (Brioverian and Ordovician–Devonian),
were studied. Results showed that the berries of vines cultivated in WWR were significantly smaller, richer in sugars and
anthocyanins and had a Total Phenolic Index higher than those of the vines cultivated in SWR. They also had a lower titratable
acidity. Cabernet Franc vines cultivated in MWR had berries with sugar and anthocyanin contents but also total phenolics very
close to those of WWR. With Chenin vines there was a good relationship between the global pool of free aromas of berries and
the BTU type. The study showed significant relationships between the quality of grapes and the measured values of several
ecophysiological variables such as the water supply regime or the timing of budburst. 相似文献