幽门螺杆菌感染和服用阿司匹林对消化性溃疡协同致病的研究

目的探讨幽门螺杆菌(Helicobacter pylori,H.pylori)感染与服用阿司匹林对消化性溃疡的分别的作用以及是否存在协同致病或者拮抗作用,了解消化性溃疡发病的致病因素的相互关系。方法选择在2017年6月至2018年6月进入医院进行治疗的250例消化性溃疡患者与250例非消化性溃疡患者作为研究对象,探究两组患者在服用相同的药物情况下,幽门螺杆菌感染与使用阿司匹林是否会具有协同致病作用。结果幽门螺杆菌感染合并服用阿司匹林患者胃溃疡OR值明显高于单纯幽门螺杆菌感染者以及单独服用阿司匹林患者之和(P0.05)。服用阿司匹林合并幽门螺杆菌感染十二指肠溃疡的OR值低于单纯幽门螺杆菌感染者以及单纯服用阿司匹林患者之和(P0.05)。胃溃疡合并上消化道出血的患者其服用阿司匹林的OR值为3.30,而十二指肠溃疡合并上消化道出血的患者服用阿司匹林的OR值为3.09,说明服用阿司匹林药物可引发十二指肠溃疡、胃溃疡合并出血,幽门螺杆菌感染合并服用阿司匹林胃溃疡并发上消化道出血、十二指肠溃疡并发上消化道出血OR值分别为1.17、3.05。结论幽门螺杆菌感染、服用阿司匹林药物均可增加消化性溃疡发病的风险,对胃溃疡发病具有协同作用,对十二指肠溃疡无协同作用,对消化性溃疡合并上消化道出血无协同致病作用。     

黄连素佐治2型糖尿病并HP感染型消化性溃疡的临床观察

目的:探讨黄连素辅助治疗2型糖尿病合并幽门螺旋杆菌(helicobacter pylori,HP)感染型消化性溃疡的临床疗效及安全性.方法:将100例被诊断为2型糖尿病合并HP感染的消化性溃疡患者随机分为黄连素治疗组和对照组,每组50例;在进行血糖控制的基础上,对照组患者给予三联(奥美拉唑胶囊、阿莫西林胶囊、克拉霉素片)抗HP治疗;黄连素治疗组则以三联+黄连素进行治疗;治疗2周后,对照组患者单用质子泵抑制剂奥美拉唑继续治疗2周;黄连素治疗组则以黄连素+奥美拉唑继续治疗2周;治疗期间每周进行1次静脉空腹血糖检查,治疗前后行胃镜检查分析溃疡的愈合程度和HP的根治情况.结果:黄连素治疗组患者溃疡愈合率及HP根治率分别为,均显著高于对照组,且可改善空腹血糖;黄连素治疗在不良反应的发生方面与对照组无显著性差异,P＞0.05.结论:对于糖尿病合并消化性溃疡的患者,黄连素佐治可有效控制空腹血糖,并显著提高消化性溃疡的临床疗效,且安全性良好,值得临床推广.     

阿司匹林引发上消化道出血的相关危险因素研究

目的:比较由阿司匹林引发上消化道出血的相关危险因素OR值,探讨其引起消化道大出血的相关机制。方法:收集哈医大四院消化内科及心内科2009年5月份至2013年6月份仅口服阿司匹林一种非甾体抗炎药的100例患者,用药过程中引发上消化道出血的49例患者作为研究组,其余未发生消化道出血的51例患者作为对照组,采集现病史、既往史、吸烟史、行凝血常规、Hp检测及胃镜检查,经单因素统计分析筛选出阿司匹林引发上消化道出血的危险因素;通过多元Logistic回归分析得出阿司匹林引发上消化道出血的独立危险因素。结果:年龄60岁、Hp感染、既往溃疡病史、糖尿病、吸烟的患者在研究组所占比例明显高于对照组,差异具有统计学意义;经多元Logistic回归后表明年龄60岁、Hp感染、既往溃疡病史、糖尿病患者和阿司匹林引发上消化道出血的OR值具有统计学差异。结论:年龄60岁、Hp感染、溃疡病史、糖尿病患者是阿司匹林引发上消化道出血的4个独立危险因素。     

乙型病毒性肝炎与上消化道血管粘膜损伤性疾病的临床分析

目的:研究乙型病毒性肝炎与上消化道血管粘膜损伤性疾病相关性。方法:回顾性分析经纤维胃镜检查的121例患者的临床资料,全部病例行纤维胃镜检查,同时采用酶免法检测病人血清HBV.121例患者分为观察组83例与对照组38例。结果:观察组的83例胃病患者即消化性溃疡,出血性或糜烂性胃十二指肠炎。患者的HBV总阳性率为65.1%。对照组38例即非血管粘膜损伤组的单纯性浅表性胃十二指肠炎患者,其HBV总阳性率为42.2%。观察组明显高于对照组,二组阳性率在统计学上有显著性差异(P<0.05)。结论:提示上消化道血管粘膜损伤与HBV感染密切相关。如何有效保护消化道血管粘膜的完整性是降低HBV感染率的重要因素。     

生长抑素联合康复新液治疗非甾体抗炎药导致上消化道出血的效果

目的探讨康复新液联合生长抑素治疗非甾体抗炎药(NSAIDs)导致上消化道出血的效果及对炎症因子的影响。方法将95例因NSAIDs引起上消化道出血患者按随机数字表法分为两组,单药组47例予生长抑素治疗,联合组48例在对照组的基础上加用康复新液治疗,观察比较两组治疗前及治疗后3 d的炎症因子水平、临床效果及不良反应情况。结果联合组治疗后总有效率高于单药组,hs-CRP及IL-6水平低于单药组,差异均有统计学意义(P0.05);两组患者的不良反应比较,差异无统计学意义(P0.05)。结论生长抑素联合康复新液可改善NSAIDs所致上消化道出血患者的应激性炎症状态,迅速止血,且安全有效。     

乙型病毒性肝炎与上消化道血管粘膜损伤性疾病的临床分析

目的：研究乙型病毒性肝炎与上消化道血管粘膜损伤性疾病相关性.方法：回顾性分析经纤维胃镜检查的121例患者的临床资料,全部病例行纤维胃镜检查,同时采用酶免法检测病人血清HBV.121例患者分为观察组83例与对照组38例.结果：观察组的83例胃病患者即消化性溃疡,出血性或糜烂性胃十二指肠炎.患者的HBV总阳性率为65.1%.对照组38例即非血管粘膜损伤组的单纯性浅表性胃十二指肠炎患者,其HBV总阳性率为42.2%.观察组明显高于对照组,二组阳性率在统计学上有显著性差异（P〈0.05）.结论：提示上消化道血管粘膜损伤与HBV感染密切相关.如何有效保护消化道血管粘膜的完整性是降低HBV感染率的重要因素.     

幽门螺杆菌根除治疗对消化性溃疡患者血清胃泌素水平的影响

目的观察幽门螺杆菌(H.pylori)根除治疗对消化性溃疡患者血清胃泌素水平的影响,为该病治疗提供参考。方法选择我院2017年8月至2019年8月收治的120例H.pylori感染的消化性溃疡患者作为观察组,根据H.pylori分型结果进一步分为HPⅠ型组和HPⅡ型组,观察组患者接受根除幽门螺杆菌治疗。选择同期入院的40例非幽门螺杆菌感染消化性溃疡患者作为对照组,对照组患者接受常规治疗。比较两组患者治疗效果、胃镜检查结果、H.pylori清除情况及血清胃泌素、IL-10、IL-17水平。结果HPⅠ型组、HPⅡ型组和对照组患者临床总有效率差异无统计学意义(92.75%、96.08%、97.50%,χ²=1.384,P=0.051)。HPⅠ型组、HPⅡ型组、对照组患者胃镜检查总有效率差异无统计学意义(91.30%,96.08%,97.50%,χ²=1.384,P=0.051)。HPⅡ型组患者幽门螺杆菌根除率高于HPⅠ型组(98.04%vs 85.51%,χ²=4.129,P=0.042)。HPⅠ型组患者治疗后血清胃泌素、IL-10、IL-17水平均高于对照组(均P<0.05)。HPⅠ型组患者治疗后血清IL-10、IL-17水平均高于HPⅡ型组(均P<0.05)。HPⅠ型组与HPⅡ型组患者治疗后血清胃泌素差异无统计学意义(t=1.918,P=0.058)。HPⅡ型组患者治疗后血清IL-10、IL-17水平均高于对照组(均P<0.05)。HPⅡ型组与对照组患者治疗后血清胃泌素差异无统计学意义(t=1.382,P=0.170)。结论不同类型H.pylori感染消化性溃疡患者行幽门螺杆菌根除治疗后临床效果无显著差异。幽门螺杆菌根除治疗可降低消化性溃疡患者血清胃泌素、IL-10、IL-17水平。     

2 型糖尿病患者幽门螺杆菌感染与超敏c 反应蛋白、血脂情况的关系

目的:探讨2型糖尿病(T2DM)患者幽门螺杆菌(HP)感染与超敏c反应蛋白(hs-CRP)、血脂水平的关系。方法:以2009年1月1日至2009年12月31日在我院体检的683例2型糖尿病患者为研究对象,根据HP感染情况分成HP阳性组(n=306)和HP阴性组(n=377),采用单因素和多因素Logistic回归分析方法,分析HP感染与hs-CRP、血脂水平的关系。结果:(1)HP阳性组的hs-CRP水平高于HP阴性组(1.14mg/L vs 0.96mg/L),差异有统计学意义(P<0.05)。(2)HP阳性组的血脂异常率(59.8%vs 50.7%)和hs-CRP异常率(20.9%vs 14.3%)均高于HP阴性组,差异均有统计学意义(均P<0.05)。(3)单因素Logistic回归分析显示,血脂异常和hs-CRP异常对HP阳性的OR值及分别为1.449和1.582,均有统计学意义(均P<0.05),多因素Logistic回归分析显示,hs-CRP异常对HP阳性的OR值为1.509,有统计学意义(P<0.05)。结论:2型糖尿病患者,HP感染可能通过增高hs-CRP水平,影响脂质代谢,触发一系列生物、生物化学级联反应,可使患者并发心血管病变的风险性增高。     

2型糖尿病患者幽门螺杆菌感染与超敏c反应蛋白、血脂情况的关系

目的：探讨2型糖尿病（T2DM）患者幽门螺杆菌（HP）感染与超敏c反应蛋白（hs-CRP）、血脂水平的关系。方法：以2009年1月1日至2009年12月31日在我院体检的683例2型糖尿病患者为研究对象,根据HP感染情况分成HP阳性组（n=306）和HP阴性组（n=377）,采用单因素和多因素Logistic回归分析方法,分析HP感染与hs-CRP、血脂水平的关系。结果：（1）HP阳性组的hs-CRP水平高于HP阴性组（1.14mg/L vs 0.96mg/L）,差异有统计学意义（P〈0.05）。（2）HP阳性组的血脂异常率（59.8%vs 50.7%）和hs-CRP异常率（20.9%vs 14.3%）均高于HP阴性组,差异均有统计学意义（均P〈0.05）。（3）单因素Logistic回归分析显示,血脂异常和hs-CRP异常对HP阳性的OR值及分别为1.449和1.582,均有统计学意义（均P〈0.05）,多因素Logistic回归分析显示,hs-CRP异常对HP阳性的OR值为1.509,有统计学意义（P〈0.05）。结论：2型糖尿病患者,HP感染可能通过增高hs-CRP水平,影响脂质代谢,触发一系列生物、生物化学级联反应,可使患者并发心血管病变的风险性增高。     

善宁联合垂体后叶素治疗肝硬化合并上消化道出血疗效观察

目的探讨醋酸奥曲肽(善宁)联合垂体后叶素治疗肝硬化合并上消化道出血的临床效果。方法选择2015年10月~2016年2月在我院消化内科接受治疗的肝硬化合并上消化道出血患者80例,随机分为对照组和观察组各40例,对照组给予去甲肾上腺素口服治疗,观察组在对照组的基础上应用善宁联合垂体后叶素静脉治疗,并对两组患者的止血效果进行比较。结果观察组的止血有效率为95%,对照组为60%(χ2=14.050,P=0.000),观察组止血效果显著高于对照组,差异具有统计学意义(P0.05)。结论善宁联合垂体后叶素治疗肝硬化合并上消化道出血的疗效显著,是治疗肝硬化合并上消化道出血的有效药物,值得临床推广应用。     

Curcuminoids as inhibitors of thioredoxin reductase: A receptor based pharmacophore study with distance mapping of the active site

Curcumin is the yellow pigment of turmeric that interacts irreversibly forming an adduct with thioredoxin reductase (TrxR), an enzyme responsible for redox control of cell and defence against oxidative stress. Docking at both the active sites of TrxR was performed to compare the potency of three naturally occurring curcuminoids, namely curcumin, demethoxy curcumin and bis-demethoxy curcumin. Results show that active sites of TrxR occur at the junction of E and F chains. Volume and area of both cavities is predicted. It has been concluded by distance mapping of the most active conformations that Se atom of catalytic residue SeCYS498, is at a distance of 3.56 from C13 of demethoxy curcumin at the E chain active site, whereas C13 carbon atom forms adduct with Se atom of SeCys 498. We report that at least one methoxy group in curcuminoids is necessary for interation with catalytic residues of thioredoxin. Pharmacophore of both active sites of the TrxR receptor for curcumin and demethoxy curcumin molecules has been drawn and proposed for design and synthesis of most probable potent antiproliferative synthetic drugs.     

A Unique Protease Cleavage Site Predicted in the Spike Protein of the Novel Pneumonia Coronavirus (2019-nCoV) Potentially Related to Viral Transmissibility

正Dear Editor,In December 2019, a novel human coronavirus caused an epidemic of severe pneumonia(Coronavirus Disease 2019,COVID-19) in Wuhan, Hubei, China(Wu et al. 2020; Zhu et al. 2020). So far, this virus has spread to all areas of China and even to other countries. The epidemic has caused 67,102 confirmed infections with 1526 fatal cases     

Comparative morphology of the carpel in the Liliaceae: Hewardieae, Petrosavieae, and Tricyrteae

The young pistils in the melanthioid tribes, Hewardieae, Petrosavieae and Tricyrteae, are uniformly tricarpellate and syncarpous. They lack raphide idioblasts. All are multiovulate, with bitegmic ovules. The Petrosavieae are marked by the presence of septal glands and incomplete syncarpy. Tepals and stamens adhere to the ovary in the Hewardieae and the Petrosavieae but not in the Tricyrteae. Two vascular bundles occur in the stamens of the Hewartlieae and Tricyrtis latifolia. Ventral bundles in the upper part of the ovary of the Hewardieae are continuous with compound septal bundles and placental bundles in the lower part. Putative ventral bundles occur in the alternate position in the Tricyrteae and putative placental bundles in the opposite. position in the Petrosavieae. The dichtomously branched stigma in each carpel of the Tricyrteae is supplied by a bifurcated dorsal bundle.     

Entwicklungsgeschichte und Ultrastruktur von Pollenkitt und Exine bei nahe verwandten entomophilen und anemophilen Angiospermensippen derAlismataceae,Liliaceae, Juncaceae,Cyperaceae, Poaceae undAraceae

Some closely related members of the monocotyledonous familiesAlismataceae, Liliaceae, Juncaceae, Cyperaceae, Poaceae andAraceae with variable modes of pollination (insect- and wind-pollination) were studied in relation to the ultrastructure of pollenkitt and exine (amount, consistency and distribution of pollenkitt on the surface of pollen grains). The character syndromes of pollen cementing in entomophilous, anemophilous and intermediate (ambophilous or amphiphilous) monocotyledons are the same in principal as in dicotyledons. Comparing present with former results one can summarize: 1) The pollenkitt is always produced in the same manner by the anther tapetum in all angiosperm sub-classes. 2) The variable stickiness of entomophilous and anemophilous pollen always depends on the particular distribution and consistency of the pollenkitt, but not its amount on the pollen surface. 3) The mostly dry and powdery pollen of anemophilous plants always contains a variable amount of inactive pollenkitt in its exine cavities. 4) A step-by step change of the pollen cementing syndrome can be observed from entomophily towards anemophily. 5) From the omnipresence of pollenkitt in all wind-pollinated angiosperms studied one can conclude that the ancestors of anemophilous angiosperms probably have been zoophilous (i.e. entomophilous) throughout.

     

Identification and Characterization of the First Equine Parainfluenza Virus 5

正Dear Editor,Parainfluenza virus 5 (PIV5), known as canine parainfluenza virus in the veterinary field, is a negative-sense,nonsegmented, single-stranded RNA virus belonging to the Paramyxoviridae family (Chen 2018). The virus was first reported in primary monkey kidney cells in 1954 (Hsiung1972), then it has been frequently discovered in various     

Pathogenic Characterization and Full Length Genome Sequence of a Reassortant Infectious Bursal Disease Virus Newly Isolated in Pakistan

<正>Dear Editor,Infectious bursal disease (IBD) is one of the most important diseases of the poultry. The IBD virus (IBDV), a nonenveloped virus belonging to the Birnaviridae family with a genome consisting of two segments of double-stranded RNA (segments A and B), targets B lymphocytes of bursa of Fabricious leading to immunosuppression. In Pakistan,poultry farming is the second biggest industry and IBD is the second biggest disease threating the poultry sector.However, there is limited genome information of IBDV