幽门螺杆菌根除治疗对消化性溃疡患者血清胃泌素水平的影响

目的观察幽门螺杆菌(H.pylori)根除治疗对消化性溃疡患者血清胃泌素水平的影响,为该病治疗提供参考。方法选择我院2017年8月至2019年8月收治的120例H.pylori感染的消化性溃疡患者作为观察组,根据H.pylori分型结果进一步分为HPⅠ型组和HPⅡ型组,观察组患者接受根除幽门螺杆菌治疗。选择同期入院的40例非幽门螺杆菌感染消化性溃疡患者作为对照组,对照组患者接受常规治疗。比较两组患者治疗效果、胃镜检查结果、H.pylori清除情况及血清胃泌素、IL-10、IL-17水平。结果HPⅠ型组、HPⅡ型组和对照组患者临床总有效率差异无统计学意义(92.75%、96.08%、97.50%,χ²=1.384,P=0.051)。HPⅠ型组、HPⅡ型组、对照组患者胃镜检查总有效率差异无统计学意义(91.30%,96.08%,97.50%,χ²=1.384,P=0.051)。HPⅡ型组患者幽门螺杆菌根除率高于HPⅠ型组(98.04%vs 85.51%,χ²=4.129,P=0.042)。HPⅠ型组患者治疗后血清胃泌素、IL-10、IL-17水平均高于对照组(均P<0.05)。HPⅠ型组患者治疗后血清IL-10、IL-17水平均高于HPⅡ型组(均P<0.05)。HPⅠ型组与HPⅡ型组患者治疗后血清胃泌素差异无统计学意义(t=1.918,P=0.058)。HPⅡ型组患者治疗后血清IL-10、IL-17水平均高于对照组(均P<0.05)。HPⅡ型组与对照组患者治疗后血清胃泌素差异无统计学意义(t=1.382,P=0.170)。结论不同类型H.pylori感染消化性溃疡患者行幽门螺杆菌根除治疗后临床效果无显著差异。幽门螺杆菌根除治疗可降低消化性溃疡患者血清胃泌素、IL-10、IL-17水平。

Effect of Helicobacter pylori eradication on serum gastrin level in patients with peptic ulcer

Objective To observe the effect of Helicobacter pylori eradication on serum gastrin level in patients with peptic ulcer and provide a reference for treatment.Methods A total of 120 peptic ulcer patients with Helicobacter pylori infection who were treated in our hospital from Aug 2017 to Aug 2019 were selected as the observation group.According to H.pylori genotyping results,they were further divided into HPⅠgroup or HPⅡgroup.The observation group received H.pylori eradication treatment.Forty peptic ulcer patients with non-Helicobacter pylori infection admitted to our hospital at the same time were selected as the control group,and received conventional treatment.The clinical effects,gastroscopy detection results,clearance of Helicobacter pylori and levels of serum gastrin,IL-10 and IL-17 were compared between two groups.Results There was no significant difference in the total efficiency rate among the HPⅠgroup,HPⅡgroup and control group(92.75%,96.08%,97.50%,χ²=1.384,P=0.051),neither in the gastroscopy results(91.30%,96.08%,97.50%,χ²=1.384,P=0.051).The eradication rate of H.pylori in the HPⅡgroup was higher than that in the HPⅠgroup(98.04%vs 85.51%,χ²=4.129,P=0.042).After treatment,the levels of serum gastrin,IL-10 and IL-17 in HPⅠgroup were higher than those in the control group(all P<0.05).Serum IL-10 and IL-17 levels in HPⅠgroup were higher than those in HPⅡgroup after treatment(all P<0.05).There was no significant difference in serum gastrin between the HPⅠgroup and the HPⅡgroup after treatment(t=1.918,P=0.058).The levels of serum IL-10 and IL-17 in the HPⅡgroup were higher than those in the control group after treatment(all P<0.05).There was no significant difference in serum gastrin between the HPⅡgroup and the control group after treatment(t=1.382,P=0.170).Conclusion There is no significant difference in the total efficiency rate among peptic ulcer patients with different H.pylori infection.Eradication of H.pylori can reduce serum levels of gastrin,IL-10 and IL-17 in patients with peptic ulcer.