贵州高原鳅属鱼类二新种(鲤形目：鳅科：条鳅亚科)

描述高原鳅属鱼类2新种,即鼻须高原鳅Triplophysa nasobarbatula sp.nov.和贞丰高原鳅Triplophysa zhenfengensis sp.nov.,采自贵州省荔波县和贞丰县（均属西江水系）。前者与云南高原鳅Tripliophysa yunnanensis Yang相似,后者与鼻须高原鳅Triplophysa nasobarbatula sp.nov.相似,正模标本均保存在遵义医学院生物学教研室。     

广西岭鳅属鱼类一新种——大鳞岭鳅记述

2008年6月20日,在广西壮族自治环江毛南县大才乡神龙宫（河）采集到一批条鳅标本。经鉴定,这批条鳅为岭鳅属(Oreonectes)一新种。新种大鳞岭鳅(O. macrolepis)属于叉尾岭鳅种组(O. furcocaudalis group)。但新种全身被有细密的鳞片;具5—12个侧线孔;眶下管孔3+7,眶上管孔为7—8;体长为尾柄高的7.0—10.8倍;头长为鼻孔处头宽的2.3—2.7倍;头长为最大头宽的1.4—1.8倍。这些特征可将新种与该种组内的其他种类相区分。     

广西云南鳅属鱼类一新种——靖西云南鳅

2008年5月,在广西壮族自治区靖西县禄洞村珠江水系采集到一批条鳅标本。经鉴定,为云南鳅属 (Yunnanilus)一新种。新种靖西云南鳅(Yunnanilus jinxiensis)属于侧纹云南鳅种组(Yunnanilus pleurotaenis group)。但新种全身除胸腹部外被有鳞片;侧线较长,具有15—20个侧线管孔;背鳍分枝鳍条8;胸鳍分枝鳍条13—14;鳔两室,后室发达;尾鳍凹形;体长为体高的3.9—4.6倍,为头长的4.1—4.4倍,为尾柄高的7.5—9.0倍;头长为眼径的5.5—6.7倍,为眼间距的2.2—2.4倍等特征,可将新种与该种组内的其他种类相区分。     

广西条鳅亚科鱼类二新种（鲤形目：鳅科）

本文记述采自广西西江水系河池地区的条鳅亚科鱼类二新种。后鳍岭鳅,新种Ｏｒｅｏｎｅｃｔｅｓ ｒｅｔｒｏｄｏｒｓａｌｉｓ ｓｐ．ｎｏｖ．与同属种的区别主要表现在其背鳍起点的位置较后、背鳍和臀鳍分枝鳍条数目较少、尾鳍后缘凹入、头较小和属柄较短等方面。南丹高原鳅,新种Ｔｒｉｐｌｏｐｈｙｓａ ｎａｎｄａｎｅｎｓｉｓ ｓｐ．ｎｏｖ．则以头较大、吻较短、眼间距较狭、尾柄较短且高、背鳍分枝鳍条较多、尾鳍深叉形等易     

四川省条鳅亚科鱼类的研究：Ⅱ.高原鳅属

本文系四川地区条鳅亚科高原鳅属鱼类的分类研究。根据过去的记录结合标本比较分析了分布于四川的高原鳅属鱼类,整理出13种和亚种,对部分种类作了校订和补充。其中粗壮高原鳅TriplophysarobustaKessler和黑体高原鳅TriplophysaobscuraWang为省的新纪录。     

四川省条鳅亚科鱼类的研究——Ⅰ.副鳅、条鳅和山鳅属鱼类的整理(鲤形目:鳅科)

本文为四川省条鳅亚科鱼类分类研究的第一部分,对分布于四川省的副鳅属(Paracobitis)、条鳅属(Nemacheilus)和山鳅属(Oreias)鱼类进行了比较系统的整理,这3个属分布在四川共有5种和亚种,其中乌江副鳅(Paracobitis wujiangensis sp.nov.)为新种。     

西藏高原鳅、细尾高原鳅和异尾高原鳅消化道结构的比较

运用解剖学、组织学方法比较研究西藏高原鳅(Triplophysa tibetana)、细尾高原鳅(Triplophysa stenura)和异尾高原鳅(Triplophysastewarti) 3种高原鳅的消化道结构。结果表明: (1)3种高原鳅的消化道均由口咽腔、食道、胃、肠组成。胃“U”型, 无幽门盲囊, 肠道短, 可分为前、中、后三个部分。异尾高原鳅胃长与消化道长比值最大, 比肠长最短, 为0.51±0.07, 与西藏高原鳅比肠长0.64±0.08和细尾高原鳅比肠长0.70±0.06, 差异显著。(2)异尾高原鳅胃黏膜层相对高度大于西藏高原鳅和细尾高原鳅, 肌肉层相对厚度也比其他2种鱼厚。前肠黏膜层为异尾高原鳅相对高度最大, 肌肉层为西藏高原鳅相对最厚。中肠与后肠黏膜层相对厚度由大到小为异尾高原鳅>细尾高原鳅>西藏高原鳅。综上所述, 3种高原鳅的消化道结构均符合肉食性鱼类特征, 推测异尾高原鳅的结构特征适于消化更多的动物性饵料。     

Recent advances in the study of Kaposi's sarcoma-associated herpesvirus replication and pathogenesis

It has now been over twenty years since a novel herpesviral genome was identified in Kaposi's sarcoma biopsies. Since then, the cumulative research effort by molecular biologists, virologists, clinicians, and epidemiologists alike has led to the extensive characterization of this tumor virus, Kaposi's sarcoma-associated herpesvirus(KSHV; also known as human herpesvirus 8(HHV-8)), and its associated diseases. Here we review the current knowledge of KSHV biology and pathogenesis, with a particular emphasis on new and exciting advances in the field of epigenetics. We also discuss the development and practicality of various cell culture and animal model systems to study KSHV replication and pathogenesis.     

A Unique Protease Cleavage Site Predicted in the Spike Protein of the Novel Pneumonia Coronavirus (2019-nCoV) Potentially Related to Viral Transmissibility

正Dear Editor,In December 2019, a novel human coronavirus caused an epidemic of severe pneumonia(Coronavirus Disease 2019,COVID-19) in Wuhan, Hubei, China(Wu et al. 2020; Zhu et al. 2020). So far, this virus has spread to all areas of China and even to other countries. The epidemic has caused 67,102 confirmed infections with 1526 fatal cases     

Curcuminoids as inhibitors of thioredoxin reductase: A receptor based pharmacophore study with distance mapping of the active site

Curcumin is the yellow pigment of turmeric that interacts irreversibly forming an adduct with thioredoxin reductase (TrxR), an enzyme responsible for redox control of cell and defence against oxidative stress. Docking at both the active sites of TrxR was performed to compare the potency of three naturally occurring curcuminoids, namely curcumin, demethoxy curcumin and bis-demethoxy curcumin. Results show that active sites of TrxR occur at the junction of E and F chains. Volume and area of both cavities is predicted. It has been concluded by distance mapping of the most active conformations that Se atom of catalytic residue SeCYS498, is at a distance of 3.56 from C13 of demethoxy curcumin at the E chain active site, whereas C13 carbon atom forms adduct with Se atom of SeCys 498. We report that at least one methoxy group in curcuminoids is necessary for interation with catalytic residues of thioredoxin. Pharmacophore of both active sites of the TrxR receptor for curcumin and demethoxy curcumin molecules has been drawn and proposed for design and synthesis of most probable potent antiproliferative synthetic drugs.     

Synthesis and antimicrobial studies of hydrazone derivatives of 4-[3-(2,4-difluorophenyl)-4-formyl-1H-pyrazol-1-yl]benzoic acid and 4-[3-(3,4-difluorophenyl)-4-formyl-1H-pyrazol-1-yl]benzoic acid

Microbial resistance to antibiotics is an unresolved global concern, which needs urgent and coordinated action. One of the guidelines of the Centers for Disease Control and Preventions (CDC) to combat antibiotic resistance is the development of new antibiotics to treat drug-resistant bacteria. In our effort to find new antibiotics, we report the synthesis and antimicrobial studies of 30 new pyrazole derivatives. These novel molecules have been synthesized by using readily available starting materials and benign reaction conditions. Some of these molecules have shown activity with MIC values as low as 0.78?µg/mL against four bacterial strains; Staphylococcus aureus, methicillin-resistant S. aureus, Bacillus subtilis, and Acinetobacter baumannii. Furthermore, active molecules are non-toxic to mammalian cell line.

     

Comparative morphology of the carpel in the Liliaceae: Hewardieae, Petrosavieae, and Tricyrteae

The young pistils in the melanthioid tribes, Hewardieae, Petrosavieae and Tricyrteae, are uniformly tricarpellate and syncarpous. They lack raphide idioblasts. All are multiovulate, with bitegmic ovules. The Petrosavieae are marked by the presence of septal glands and incomplete syncarpy. Tepals and stamens adhere to the ovary in the Hewardieae and the Petrosavieae but not in the Tricyrteae. Two vascular bundles occur in the stamens of the Hewartlieae and Tricyrtis latifolia. Ventral bundles in the upper part of the ovary of the Hewardieae are continuous with compound septal bundles and placental bundles in the lower part. Putative ventral bundles occur in the alternate position in the Tricyrteae and putative placental bundles in the opposite. position in the Petrosavieae. The dichtomously branched stigma in each carpel of the Tricyrteae is supplied by a bifurcated dorsal bundle.     

Novel compounds with potent CDK9 inhibitory activity for the treatment of myeloma

Cyclin-dependent kinases (CDKs) and Polo-like kinases (PLKs) play key role in the regulation of the cell cycle. The aim of our study was originally the further development of our recently discovered polo-like kinase 1 (PLK1) inhibitors. A series of new 2,4-disubstituted pyrimidine derivatives were synthesized around the original hit, but their PLK1 inhibitory activity was very poor. However the novel compounds showed nanomolar CDK9 inhibitory activity and very good antiproliferative effect on multiple myeloma cell lines (RPMI-8226).