工科院校微生物学实验教学改革与实践

传统的微生物学实验教学方法和内容存在着许多不足。因此, 我们从实验教学内容、教学模式和实验考核方法等方面进行了改革和探索, 将微生物学实验单独设课, 并增设了微生物学综合实验。结果显示新的实验教学模式更有利于培养学生的动手能力、创新能力以及综合能力, 其教学效果大大提高。     

体现不同专业特色的微生物学实验教学改革研究

总结了微生物学实验教学的改革与实践.根据专业特点设置基础验证性实验以加强基本操作技能训练,开设有专业特色的综合、设计性实验强化学生综合实践能力培养,利用创新性实验促进培养学生创新能力,并依托网络化的实验教学信息平台与完善的实验室管理制度实施开放实验,构建了体现专业特色的微生物学实验教学体系.实践证明,体现专业特色的微生物学实验教学改革,提高了实验效率与实验教学质量.     

改革微生物学实验教学,提高学生实验技能

微生物学是一门实验性和应用性很强的学科,它具有一套独特的实验技术和方法,微生物学实验技术已被广泛应用于生产实践、科学研究过程中.从课程实验和综合实验两方面就不断改进微生物学实验教学,训练学生基本实验操作技能,培养学生综合创新能力的方法和途径.     

食品微生物学实验课教学改革的初步探索

为了提高学生实验动手能力和实验教学效果 ,对食品科学与工程专业《食品微生物学》实验课教学进行了改革探索 ,在原有实验的基础上增加了综合性大实验“食品卫生微生物指标检测”。对实验教学方法进行了改革 ,结果证明 :综合实验对学生实验动手能力有很大提高。实验教学方法的改革 ,提高了实验教学效果。     

食品微生物学实验课立体化教学体系的构建

通过对食品微生物学实验课教学内容、教学手段和方法以及考核方法等方面进行改革,构建了一套基础性实验—综合提高性实验—创新性实验的立体化实验教学体系,使其教学系统化、课程层次化、内容多样化,使学生的综合能力得到了良好的训练,培养了创新意识和综合实验能力,达到了较好的教学效果.     

生物工程专业微生物学实验教学改革探讨

针对生物工程专业微生物学实验教学改革中遇到的问题,结合自身教学实践,从实验时序性、开放性实验、考核考勤体制及教学方法等方面,提出如何提高微生物学实验教学质量、提高学生创新能力和学习能力。     

改革微生物学实验教学方法, 提高学生综合能力

为了使学生在微生物学实验课程中注重动手动脑能力的培养, 提高自身综合能力, 成为高素质的专业技术人才, 本文对微生物学实验教学中的教学进度、教材、学生能力的培养方式和考核方式等方面进行了探讨和改革。     

基于“互联网+”探究型实验教学模式在“微生物学实验”课程中的探索与应用

从"微生物学实验"课程教学内容和方法改革入手,针对中医药高等院校"微生物学实验"教学的新挑战和新要求,以互联网为基础,构建三大网络教学平台,运用多种教学资源和方法,整合实验教学内容,采用模块化实验教学模式,开展以研究型实验为主的实验项目进行教学改革的探索和应用,旨在不断提高"微生物学实验"课程的教学质量,培养医学生的科研思维能力、创新能力和团队协作精神,并提高学生的综合素质。     

微生物学创新实验教学体系的构建与实践

培养学生的创新能力与实践能力是现代大学教育的共同教育理念。根据多年来微生物学实验教学的改革与实践,对实验内容进行了精心的调整、完善和更新,按"基本技能训练、综合能力培养、研究素质及创新意识培育"的基本宗旨,构建了从"综合实验—探究性自选实验—项目申报"的微生物创新实验教学体系,使实验教学遵循基础性、综合性、研究性、开放性的基本原则,有效提高学生的微生物学实验技能。     

提高微生物学实验课教学效果的探索与尝试

针对传统实验教学法造成学生学习被动和积极性不高等问题, 在微生物实验教学实践中我们以培养学生能力为重点, 对实验教学内容、实验教学方式、实验教学管理以及考核方式等方面的改革进行了探索与尝试。教学实践证明从微生物学实验教学的正确定位出发, 规范实验教学大纲, 采用基本技能训练模块、综合实验模块和创新实验模块相结合的教学方式和实验室开放教学管理模式是提高微生物实验教学效果的成功之举, 对提高学生综合素质具有重要作用。     

Curcuminoids as inhibitors of thioredoxin reductase: A receptor based pharmacophore study with distance mapping of the active site

Curcumin is the yellow pigment of turmeric that interacts irreversibly forming an adduct with thioredoxin reductase (TrxR), an enzyme responsible for redox control of cell and defence against oxidative stress. Docking at both the active sites of TrxR was performed to compare the potency of three naturally occurring curcuminoids, namely curcumin, demethoxy curcumin and bis-demethoxy curcumin. Results show that active sites of TrxR occur at the junction of E and F chains. Volume and area of both cavities is predicted. It has been concluded by distance mapping of the most active conformations that Se atom of catalytic residue SeCYS498, is at a distance of 3.56 from C13 of demethoxy curcumin at the E chain active site, whereas C13 carbon atom forms adduct with Se atom of SeCys 498. We report that at least one methoxy group in curcuminoids is necessary for interation with catalytic residues of thioredoxin. Pharmacophore of both active sites of the TrxR receptor for curcumin and demethoxy curcumin molecules has been drawn and proposed for design and synthesis of most probable potent antiproliferative synthetic drugs.     

A Unique Protease Cleavage Site Predicted in the Spike Protein of the Novel Pneumonia Coronavirus (2019-nCoV) Potentially Related to Viral Transmissibility

正Dear Editor,In December 2019, a novel human coronavirus caused an epidemic of severe pneumonia(Coronavirus Disease 2019,COVID-19) in Wuhan, Hubei, China(Wu et al. 2020; Zhu et al. 2020). So far, this virus has spread to all areas of China and even to other countries. The epidemic has caused 67,102 confirmed infections with 1526 fatal cases     

Comparative morphology of the carpel in the Liliaceae: Hewardieae, Petrosavieae, and Tricyrteae

The young pistils in the melanthioid tribes, Hewardieae, Petrosavieae and Tricyrteae, are uniformly tricarpellate and syncarpous. They lack raphide idioblasts. All are multiovulate, with bitegmic ovules. The Petrosavieae are marked by the presence of septal glands and incomplete syncarpy. Tepals and stamens adhere to the ovary in the Hewardieae and the Petrosavieae but not in the Tricyrteae. Two vascular bundles occur in the stamens of the Hewartlieae and Tricyrtis latifolia. Ventral bundles in the upper part of the ovary of the Hewardieae are continuous with compound septal bundles and placental bundles in the lower part. Putative ventral bundles occur in the alternate position in the Tricyrteae and putative placental bundles in the opposite. position in the Petrosavieae. The dichtomously branched stigma in each carpel of the Tricyrteae is supplied by a bifurcated dorsal bundle.     

Entwicklungsgeschichte und Ultrastruktur von Pollenkitt und Exine bei nahe verwandten entomophilen und anemophilen Angiospermensippen derAlismataceae,Liliaceae, Juncaceae,Cyperaceae, Poaceae undAraceae

Some closely related members of the monocotyledonous familiesAlismataceae, Liliaceae, Juncaceae, Cyperaceae, Poaceae andAraceae with variable modes of pollination (insect- and wind-pollination) were studied in relation to the ultrastructure of pollenkitt and exine (amount, consistency and distribution of pollenkitt on the surface of pollen grains). The character syndromes of pollen cementing in entomophilous, anemophilous and intermediate (ambophilous or amphiphilous) monocotyledons are the same in principal as in dicotyledons. Comparing present with former results one can summarize: 1) The pollenkitt is always produced in the same manner by the anther tapetum in all angiosperm sub-classes. 2) The variable stickiness of entomophilous and anemophilous pollen always depends on the particular distribution and consistency of the pollenkitt, but not its amount on the pollen surface. 3) The mostly dry and powdery pollen of anemophilous plants always contains a variable amount of inactive pollenkitt in its exine cavities. 4) A step-by step change of the pollen cementing syndrome can be observed from entomophily towards anemophily. 5) From the omnipresence of pollenkitt in all wind-pollinated angiosperms studied one can conclude that the ancestors of anemophilous angiosperms probably have been zoophilous (i.e. entomophilous) throughout.

     

Identification and Characterization of the First Equine Parainfluenza Virus 5

正Dear Editor,Parainfluenza virus 5 (PIV5), known as canine parainfluenza virus in the veterinary field, is a negative-sense,nonsegmented, single-stranded RNA virus belonging to the Paramyxoviridae family (Chen 2018). The virus was first reported in primary monkey kidney cells in 1954 (Hsiung1972), then it has been frequently discovered in various