南海北部0.36-1.02Ma高分辨率碳屑记录及天然火

依据南海ODP1144站下段（225．7－501．3m,ca.0.36-1.02Ma)碳屑、孢粉记录,将1144站下段225.7-501.3m划分19个碳屑、孢粉组合带（11－29）,并分别与氧同位素11－29期（MIS11－29）相对应。冰期时,草本植物花粉和碳屑总沉积率增加,气候干燥,天然火的强度较大;冰期MIS24,大陆内部及冰期出露的大陆架上的天然火灾强度相对最弱;而冰期MIS12,大陆内部及冰期出露的大陆架上的天然火灾强度相对最强;间冰期气候湿润,草本花粉和碳屑总沉积率降低。一方面由于间冰期海平面上升,大陆架被淹没,导致碳屑来源减少;另一方面亦反应天然火灾强度减低。间冰期MIS17,25和27碳屑沉积率分别较冰期MIS18,24及26略高,推测间冰期MIS17,25和27冬季风强度仍相对较强,大陆内部天然火灾强度亦相对较强。     

贝加尔湖-钻孔(BDP 96-1)的孢粉分析

贝加尔钻探计划（BDP）中的96－1井位于贝加尔湖中央的科学湖脊,1996年冬从位于332m水深以下的钻井采样,钻孔从湖底向下深2000m,根据古地磁资料,钻孔年代推测为5．1Ma,Tsuga,Lepidobalanus,Ulmaceae,Tilia和Corylus发现于钻孔的下部约60m,因为这些化石花粉目前在贝加尔湖地区已经消失,说明该钻孔上部的气候比下部的冷,因此,第四纪的气候比晚第三纪的更为干冷。在亚北极的西伯利亚,冰期时期以草本植物花粉占统治地位,花粉浓度较低,而在间冰期时期以木本花粉为主,花粉浓度较高,在间冰期时期硅藻及有机物总量增加,潮湿度（wet density)及氧同位素比率都降低,相反,在冰期时期硅藻含量及有机物总量降低,而潮湿度（wet dendity)和氧同位素比率都增加。     

热带雨林的孢粉垂直分布规律——以海南岛现代孢粉雨为例

热带地区环境变化对研究全球气候变化显得越来越重要,热带地区的古环境记录,特别是孢粉记录是恢复过去气候的重要方法,东亚热带地区在冰期－间冰期的气候影响下,生态环境主要表现为山地植被带的垂直升降,因此,定量恢复热带地区第四纪植被垂直移动的幅度,以及作为古气候的替代性指标进行数量化转换是热带地区孢粉研究的关键,然而,我国热带地区现代孢粉雨和植被的关系研究程度较低,给热带第四纪孢粉古生态的恢复和对比带来困难,本研究较系统地总结了海南岛从低地平原到五指山1860m的垂直植被带表土的孢粉散布规律,为热带地区孢粉古环境的重建提供了新的基础数据。研究结果表明,孢粉组合的变化与垂直植被带紧密相关,孢粉的多样性随海拔升高而降低,其中针叶类随海拔升高而增加,蕨类孢子则相应减少,在低地和低山丘陵,孢粉组合显示出为干扰的影响,如防风雨的主要树种木麻黄（Casuarina),行道树台湾相思（Acacia richii)和人为砍伐后大面积生长的芒箕（Dicranopteris)群落等在一些孢粉谱中特别高,尽管如此,孢粉组合反映的垂直植被带变化仍然是清楚的,海南岛由下至上可划分出5个表土孢粉组合带－低地人类强烈干扰带（＜400m):Mallotus,Casuarina,Pinus,Myrica,Palmae,Poaceaae,Dicranopteris:--低地质陵地带（400－800m):Quercus,Castanopsis,Mallotus,Myrica,Platea,Meliaceae和大量孢子（包括Dicranopteris);--山地下带（800-1200m):Castanopsis,Quercus,Podocarpus,Dacrydium,Cyathea和单缝孢子;－－山地上带（1200-1600m):Dacrydium,Pinus,Altingia,Quercus,Castanopsis;－－山顶带（＞1600m):Pinus,Rhododendron,Dacrydium,Symplocos.     

新疆三塘湖盆地塘浅3井中侏罗世孢粉组合

本文对在新疆三塘湖盆地塘浅3井106-701m层段发现的孢粉化石进行了系统的分析研究,共获孢子花粉52属120种（包括相似种和未定种）,疑源类化石2属2种及一个未定类型,根据孢粉属种及其含量的变化,自下而上分为两套组合;1）Cyathidites minor-Osmundacidites-Cycadopites-Quadraeculina组合;2）Kraeuselisporites ma-nasiensis-Classopollis-Quadraeculina组合,第一组合产于该井413-710m层段。时代归为中侏罗世早期,赋存地层相当于西山窑组;第二组合产于106-413m,时代归为中侏罗世晚期,赋存地层相当于头屯河组,系统分析组合中主要孢粉属种及其母体植物的生长环境,推测新疆三塘湖盆地及其周围地区在中侏罗世早期为温带或亚热带气候,晚期为亚热带气候。     

新近系谢家阶层型剖面的孢粉植物群及其意义

在中国新近系建阶研究中,文章作者对中新统最下部的一个阶谢家阶层型剖面开展了古地磁、孢粉等方面的综合研究工作。文中是在磁性地层学的时间标尺上,着重讨论孢粉植物群的变化规律。谢家阶层型剖面中发现的孢粉组合特征,总体上与我国中新世早期的孢粉植物群变化规律相一致。但裸子植物花粉,尤其是云杉（Picea）花粉的含量在两个含孢粉丰富的样品中,由下到上明显增加,反映出研究区早中新世气候具有趋冷特征,与同期深海氧同位素变化规律可相对比。而耐旱植物,尤其是藜科（Chenopodiaceae）和蒺藜科（Zygophyllaceae）白刺属（Nitraria）花粉的含量明显降低,反映谢家期后期孢粉组合所指示的湿度具有较明显的增加,推测与东亚季风在新近纪的发展存在着一定的耦合关系。此外,蒿属（Artemisia）花粉在样品中时有见到,与其在我国新近纪地层中的分布规律相一致,与车头沟剖面古地磁的测量结果相吻合。     

重庆喀斯特地区现代花粉组合与植被的关系

重庆喀斯特地区4种不同地貌单元的81份表土和苔藓样品的孢粉分析结果表明:(1)研究区植物孢粉组合共由109科属组成。除金佛山外,其他植被退化严重地区样点均以草本和蕨类植物占据优势(剔除石漠化治理大量引种的马尾松、柳杉和侧柏等乔木花粉),其次是乔木植物花粉(主要为马尾松),灌木植物花粉含量很低,显示该区植被退化严重;(2)孢粉组合的PCA分析能够很好地将研究区的现代孢粉组合区分开来,较好地反映了重庆喀斯特地区不同地貌单元的植被特征,特别是石漠化区植被退化严重的孢粉组合特征。生态保护较好、自然植被发育的金佛山地区具有106科属的乔木、灌木与草本孢粉类型,以及高含量的乔木花粉,而喀斯特石漠化地区的鸡公山(46科属)、青木关镇(56科属)和南平镇(50科属)则表现为乔灌木孢粉类型较少;(3)银杉作为金佛山特有的孑遗植物,其花粉含量明显低于松属花粉,说明其花粉不利于远距离传播;(4)随着土地利用强度的增加,现代孢粉组合中乔灌木花粉含量和种类越少,草本和蕨类植物孢粉含量越多,且以耕地杂草为主。因此,土地利用方式的变化是喀斯特石漠化区次生植被及其现代孢粉组合变化的主要影响因素。研究可为重庆喀斯特地区土地利用策略的制定,重庆及其周边地区第四纪古植被、古气候和古环境重建研究,以及中国孢粉数据库建设提供基本数据和科学依据。     

广西合浦盆地古新世上洋组孢粉组合及其地层意义

广西合浦盆地上洋组在亚1井中有很好的揭示,明显表现为三分特征。作者通过对该井上洋组微体植物化石的研究,建立了三个孢粉、藻类组合,由下而上分别为:Boehlensipollis-Tricolporo-pollenites-Tricolpites-Ulmoideipites组合;Boehlensipollis qingjiangensis-Ulmoideipites-Nuxpollen-ites-Pentapollenites组合和Pinaceae-Ulmaceae-Liqudambarpollenites-Conicoidium组合。前两个组合可与北部湾长流组及广东南雄盆地上湖组等地古新世孢粉组合进行对比。第三个组合以松科花粉含量突然增加为特征,在我国许多地区晚古新世孢粉组合中都有反映。 上洋组植被在古新世早、中期以阔叶植物为特征,指示一种热带—亚热带型气候,早期干旱,中期略有缓和,晚期植被以针叶阔叶混交林为特征,表明气候变温凉。     

松辽盆地来D13井地层划分对比研究

岩石组合特征和同位素数据表明,松辽盆地来D13井137.0—142.0m井段属于早白垩世晚期(Aptian—Albian期)营城组。104.2—137.0m井段光山核桃粉(Caryapollenites simplex)-拟榛莫米粉(Momipites coryloides)-朴粉未定种(Celtispollenites sp.)-具缘铁杉粉(Tsugaepollenites igniculus)组合特征可以与前人的大安组孢粉组合特征对比,反映的都是暖温带至北亚热带中生气候,而与晚白垩世嫩江组的孢粉组合特征截然不同,应该确定为早中新世晚期至中中新世的大安组。54.2—104.2m井段小蒿粉(Artemisiaepollenites minor)-拟桦粉未定种(Betulaceoipollenites sp.)-枥粉未定种(Carpinipites sp.)-水龙骨单缝孢未定种(Polypodiaceaesporites sp.)组合特征可以与前人的泰康组孢粉组合特征对比,反映的都是暖温带至北亚热带中生偏旱气候,这与前人依据岩石组合特征确定为泰康组的结论一致,孢粉组合时代分析表明,该井段沉积的时间为晚中新世至上新世初期。研究结果丰富了松辽盆地新近纪孢粉地层学内容,为松辽盆地西部斜坡区井下新近纪孢粉地层学对比提供了新资料,也为邻区新近纪生物地层学对比以及古植被和古气候分析提供了新的依据。     

四川螺髻山表土和化石孢粉揭示的环境生态意义

通过四川螺髻山（1984、2017年）表土和化石孢粉与植被的关系分析发现：孢粉组合中木本植物含量（91.0%）占绝对优势,松属、冷杉属、青冈属、常绿栎类、落叶栎类、桤木属、杜鹃花科、禾本科和蒿属为主要花粉类型;人工次生林花粉组合能很好地反映母体植被的群落特征,并可指示优势种的存在和人类活动痕迹;针阔混交林花粉组合能较好地反映群落整体特征,花粉类型能与母体植被中优势种较好地对应;常绿阔叶林、针叶林和灌丛草甸的花粉组合难以反映母体植被的群落特征。DCA表明,花粉谱的百分含量,能较好地区分人工扰动植被和天然植被,但人工次生林、常绿阔叶林和针阔混交林之间以及针叶林和灌丛草甸之间未能区分。30年前后表土孢粉组合变化明显,1984年样品以松属、青冈属和桤木属等花粉为主,而2017年采样分析中松属、桤木属花粉占绝对优势。随着人类活动的加强,部分地区松树和桤木大面积飞播或种植,表土孢粉组合对当地植被指示意义与扰动强度呈负相关关系。现生植被与表土孢粉组合的差异能为恢复古植被和古环境提供参考,但原生植被已经被破坏地区的孢粉图谱,就很难作为重建历史时期植被的根据。本研究可以为亚热带山地利用孢粉学恢复第四纪时期植被与气候,探讨人类活动与环境的关系提供理论依据和实践参考。     

天津张贵庄晚二叠世孢粉植物群

天津张贵庄SR13号钻孔原归为石盒子组的地层近顶部发现了丰富的孢粉化石,这一组合兼具上石盒子组和孙家沟组孢粉组合的特征。一方面,它与上石盒子组（特别是其上部）组合有不少共同分子,在蕨类孢子和裸子植物花粉（包括具肋花粉）的含量比例上也可以与之对比,但缺乏一些标志分子。另一方面,在属种组成上,当前组合与已知的孙家沟组合也颇可比较,而且出现了一些中生代色彩的分子。这一组合的揭示与研究有助于提高人们对华北晚二叠世晚期孢粉植物群特征的认识。依据当前组合与已知相关孢粉组合的对比讨论,将其时代定为晚二叠世,并倾向于晚二叠世晚期（对应于孙家沟组）。     

A Unique Protease Cleavage Site Predicted in the Spike Protein of the Novel Pneumonia Coronavirus (2019-nCoV) Potentially Related to Viral Transmissibility

正Dear Editor,In December 2019, a novel human coronavirus caused an epidemic of severe pneumonia(Coronavirus Disease 2019,COVID-19) in Wuhan, Hubei, China(Wu et al. 2020; Zhu et al. 2020). So far, this virus has spread to all areas of China and even to other countries. The epidemic has caused 67,102 confirmed infections with 1526 fatal cases     

Curcuminoids as inhibitors of thioredoxin reductase: A receptor based pharmacophore study with distance mapping of the active site

Curcumin is the yellow pigment of turmeric that interacts irreversibly forming an adduct with thioredoxin reductase (TrxR), an enzyme responsible for redox control of cell and defence against oxidative stress. Docking at both the active sites of TrxR was performed to compare the potency of three naturally occurring curcuminoids, namely curcumin, demethoxy curcumin and bis-demethoxy curcumin. Results show that active sites of TrxR occur at the junction of E and F chains. Volume and area of both cavities is predicted. It has been concluded by distance mapping of the most active conformations that Se atom of catalytic residue SeCYS498, is at a distance of 3.56 from C13 of demethoxy curcumin at the E chain active site, whereas C13 carbon atom forms adduct with Se atom of SeCys 498. We report that at least one methoxy group in curcuminoids is necessary for interation with catalytic residues of thioredoxin. Pharmacophore of both active sites of the TrxR receptor for curcumin and demethoxy curcumin molecules has been drawn and proposed for design and synthesis of most probable potent antiproliferative synthetic drugs.     

Comparative morphology of the carpel in the Liliaceae: Hewardieae, Petrosavieae, and Tricyrteae

The young pistils in the melanthioid tribes, Hewardieae, Petrosavieae and Tricyrteae, are uniformly tricarpellate and syncarpous. They lack raphide idioblasts. All are multiovulate, with bitegmic ovules. The Petrosavieae are marked by the presence of septal glands and incomplete syncarpy. Tepals and stamens adhere to the ovary in the Hewardieae and the Petrosavieae but not in the Tricyrteae. Two vascular bundles occur in the stamens of the Hewartlieae and Tricyrtis latifolia. Ventral bundles in the upper part of the ovary of the Hewardieae are continuous with compound septal bundles and placental bundles in the lower part. Putative ventral bundles occur in the alternate position in the Tricyrteae and putative placental bundles in the opposite. position in the Petrosavieae. The dichtomously branched stigma in each carpel of the Tricyrteae is supplied by a bifurcated dorsal bundle.     

Enterovirus 71 3C proteolytically processes the histone H3 N-terminal tail during infection

Highlights
1. The N-terminal tail of histone H3 is specifically cleaved during EV71 infection.
2. Viral protease 3C is identified as a protease responsible for proteolytically processing the N-terminal H3 tail.
3. Our finding reveals a new epigenetic regulatory mechanism for Enterovirus 71 in virus-host interactions.     

Detection of EBV and HHV6 in the Brain Tissue of Patients with Rasmussen’s Encephalitis

Rasmussen’s encephalitis (RE) is a rare pediatric neurological disorder, and the exact etiology is not clear. Viral infection may be involved in the pathogenesis of RE, but conflicting results have reported. In this study, we evaluated the expression of both Epstein-Barr virus (EBV) and human herpes virus (HHV) 6 antigens in brain sections from 30 patients with RE and 16 control individuals by immunohistochemistry. In the RE group, EBV and HHV6 antigens were detected in 56.7% (17/30) and 50% (15/30) of individuals, respectively. In contrast, no detectable EBV and HHV6 antigen expression was found in brain tissues of the control group. The co-expression of EBV and HHV6 was detected in 20.0% (6/30) of individuals. In particular, a 4-year-old boy had a typical clinical course, including a medical history of viral encephalitis, intractable epilepsy, and hemispheric atrophy. The co-expression of EBV and HHV6 was detected in neurons and astrocytes in the brain tissue, accompanied by a high frequency of CD8⁺ T cells. Our results suggest that EBV and HHV6 infection and the activation of CD8⁺ T cells are involved in the pathogenesis of RE.     

Perinatal Vertical Transmission of Chikungunya Virus in Ruili,a Town on the Border between China and Myanmar

正Dear Editor,Chikungunya virus (CHIKV), an arbovirus in the family of Togaviridae, genus Alphavirus, is transmitted by the A.aegyptii or A. albopictus mosquito, and causes disease in humans characterized by fever, rash, and arthralgia (Silva and Dermody 2017; Suhrbier 2019). It was first reported in 1953 in Tanzania, and caused only a few outbreaks and sporadic cases in Africa and Asia in last century. However, in the epidemic in 2004, CHIKV acquired mutations that conferred enhanced transmission by the A. albopictus mosquito(Schuffenecker et al. 2006). Since then, it has successively caused outbreaks in Africa, the Indian Ocean, South East Asia, the South America, and Europe (Zeller et al. 2016).     

Development of a Novel Reverse Transcription Loop-Mediated Isothermal Amplification Method for Rapid Detection of SARS-CoV-2

In conclusion, the novel visual RT-LAMP assay is a simple, rapid, and sensitive approach for detection of SARS-CoV-2, and it is ready for application in primary care and community hospitals or health care centers, and even patients' own houses in response to the current SARS-CoV-2 epidemic because the assay does not require sophisticated equipment and skilled personnel. Furthermore, it is also ready to be used in fields for screening samples from wild animals and environments to facilitate the identification of potential intermediate hosts that mediate the cross-species transmission of SARS-CoV-2 from bats to humans.