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Enterovirus 71 3C proteolytically processes the histone H3 N-terminal tail during infection |
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| Authors: | Meng Miao Gang Deng Xiaobei Xiong Yang Qiu Wenda Huang Meng Yuan Fei Yu Shimei Bai Xi Zhou Xiaolu Zhao |
| Institution: | a Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, 430072, Chinab Institute of Biochemistry, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, 310018, Chinac Laboratory of RNA Virology, Wuhan Institute of Virology, Chinese Academy of Science, Wuhan, 430071, China |
| Abstract: | Highlights 1. The N-terminal tail of histone H3 is specifically cleaved during EV71 infection. 2. Viral protease 3C is identified as a protease responsible for proteolytically processing the N-terminal H3 tail. 3. Our finding reveals a new epigenetic regulatory mechanism for Enterovirus 71 in virus-host interactions. |
| Keywords: | , , , , |
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