2017年8月,在浙江省拟建淳安磨心尖省级自然保护区和拟建东阳市东江源省级自然保护区捕获麝鼩属（Crocidura）共5号标本。基于线粒体细胞色素b基因构建的系统发育树显示采集于浙江的麝鼩属样本与大麝鼩（Crocidura lasiura）和日本麝鼩（Crocidura dsinezumi）构成姊妹群,遗传距离最近,而与中国西南部分布的小体型印支小麝鼩（Crocidura indochinensis）、五指山小麝鼩（Crocidura wuchihensis）及东北部分布的山东小麝鼩（Crocidua shantungensis）、北小麝鼩（Crocidua suaveolens）亲缘关系较远,其遗传距离分别为0.114、0.124、0.139和0.144。这些样本与麝鼩属其他物种之间的遗传距离在0.101~0.155之间,最小遗传距离出现在来自浙江的样本和大麝鼩之间,最大遗传距离在浙江样本与中麝鼩之间。形态上,采集于浙江的麝鼩属标本个体小,体长48~61mm（平均：55.60mm）,尾长35~49mm（平均：43.14mm）;尾长与体长之比72.92%~80.36%;尾近乎裸露,尾基1/3~1/2着生稀疏长毛;尾上下双色,背部黑褐色,腹部较淡;颅较短,颅全长15.60~17.16mm（平均：16.46mm）,与中国东北部分布的山东小麝鼩和北小麝鼩相近又有区别,与已知其它麝鼩属物种形态差异较大;综合形态和系统发育关系证实采集于浙江的麝鼩属物种为一新物种,命名为东阳江麝鼩（Crocidura dongyangjiangensis Liu Y, Chen SD, and Liu SY sp. nov.）。本文对其形态、栖息环境和与近缘种的区别进行了详细记述。 相似文献
It has now been over twenty years since a novel herpesviral genome was identified in Kaposi's sarcoma biopsies. Since then, the cumulative research effort by molecular biologists, virologists, clinicians, and epidemiologists alike has led to the extensive characterization of this tumor virus, Kaposi's sarcoma-associated herpesvirus(KSHV; also known as human herpesvirus 8(HHV-8)), and its associated diseases. Here we review the current knowledge of KSHV biology and pathogenesis, with a particular emphasis on new and exciting advances in the field of epigenetics. We also discuss the development and practicality of various cell culture and animal model systems to study KSHV replication and pathogenesis. 相似文献
正Dear Editor,In December 2019, a novel human coronavirus caused an epidemic of severe pneumonia(Coronavirus Disease 2019,COVID-19) in Wuhan, Hubei, China(Wu et al. 2020; Zhu et al. 2020). So far, this virus has spread to all areas of China and even to other countries. The epidemic has caused 67,102 confirmed infections with 1526 fatal cases 相似文献
Curcumin is the yellow pigment of turmeric that interacts irreversibly forming an adduct with thioredoxin reductase (TrxR), an enzyme
responsible for redox control of cell and defence against oxidative stress. Docking at both the active sites of TrxR was performed to compare
the potency of three naturally occurring curcuminoids, namely curcumin, demethoxy curcumin and bis-demethoxy curcumin. Results show
that active sites of TrxR occur at the junction of E and F chains. Volume and area of both cavities is predicted. It has been concluded by
distance mapping of the most active conformations that Se atom of catalytic residue SeCYS498, is at a distance of 3.56 from C13 of
demethoxy curcumin at the E chain active site, whereas C13 carbon atom forms adduct with Se atom of SeCys 498. We report that at least
one methoxy group in curcuminoids is necessary for interation with catalytic residues of thioredoxin. Pharmacophore of both active sites of
the TrxR receptor for curcumin and demethoxy curcumin molecules has been drawn and proposed for design and synthesis of most probable
potent antiproliferative synthetic drugs. 相似文献
The young pistils in the melanthioid tribes, Hewardieae, Petrosavieae and Tricyrteae, are uniformly tricarpellate and syncarpous. They lack raphide idioblasts. All are multiovulate, with bitegmic ovules. The Petrosavieae are marked by the presence of septal glands and incomplete syncarpy. Tepals and stamens adhere to the ovary in the Hewardieae and the Petrosavieae but not in the Tricyrteae. Two vascular bundles occur in the stamens of the Hewartlieae and Tricyrtis latifolia. Ventral bundles in the upper part of the ovary of the Hewardieae are continuous with compound septal bundles and placental bundles in the lower part. Putative ventral bundles occur in the alternate position in the Tricyrteae and putative placental bundles in the opposite. position in the Petrosavieae. The dichtomously branched stigma in each carpel of the Tricyrteae is supplied by a bifurcated dorsal bundle. 相似文献
Microbial resistance to antibiotics is an unresolved global concern, which needs urgent and coordinated action. One of the guidelines of the Centers for Disease Control and Preventions (CDC) to combat antibiotic resistance is the development of new antibiotics to treat drug-resistant bacteria. In our effort to find new antibiotics, we report the synthesis and antimicrobial studies of 30 new pyrazole derivatives. These novel molecules have been synthesized by using readily available starting materials and benign reaction conditions. Some of these molecules have shown activity with MIC values as low as 0.78?µg/mL against four bacterial strains; Staphylococcus aureus, methicillin-resistant S. aureus, Bacillus subtilis, and Acinetobacter baumannii. Furthermore, active molecules are non-toxic to mammalian cell line.相似文献
Cyclin-dependent kinases (CDKs) and Polo-like kinases (PLKs) play key role in the regulation of the cell cycle. The aim of our study was originally the further development of our recently discovered polo-like kinase 1 (PLK1) inhibitors. A series of new 2,4-disubstituted pyrimidine derivatives were synthesized around the original hit, but their PLK1 inhibitory activity was very poor. However the novel compounds showed nanomolar CDK9 inhibitory activity and very good antiproliferative effect on multiple myeloma cell lines (RPMI-8226). 相似文献
