南岭自然保护区真菌资源调查名录之二

报道作者在南岭自然保护区调查所发现的各类真菌资源情况。报道高等植物上的寄生菌５３种,枯枝落叶层的腐生菌５２种和昆虫上的寄生菌１种,共计１０６种     

正常猕猴血象分析

关于猕猴血象,过去文献上有些报道。如1958年克利斯 (Krise) 氏曾报道了538例猕猴血象。1959年马秀权等报道了33例猕猴血象。1962年乌沙切夫曾报道了45例猕猴血象。本文主要报道在我们的营养饲料方法等具体条件下,猕猴的血象情况。     

提型杂种小麦花药培养出愈和分化的研究

应用花药单倍体培养技术选育新品种,在小麦常规育种上正被逐步认识。然而把这一技术应用到作物杂种优势利用研究中,目前国内仅在水稻上有报道,而在杂种小麦的花培研究上还未见报道。我们从1980年开始连续     

安徽黄山木本植物区系中一些种的细胞学研究(Ⅰ)

报道了黄山地区１８种木本植物的染色体数,分属于１５个科中的１８个属,其中１４种和２个属为首次报道,同时对Ａｐｈａｎａｎｔｈｅ,Ｆｏｒｔｕｎｅａｒｉａ,Ｌｏｒｏｐｅｔａｌｕｍ,Ｈｏｌｂｏｅｌｌｉａ,Ｐｌａｔｙ－ｃａｒｙａ属的染色体数及其在分类上上的意义作了简单讨论。     

生于禾本科植物上的链格孢属一新种

报道生于禾本科植物上的链格孢属一新种黑麦草生链格孢Alternarialoliicola,此种引起黑麦草穗腐,不同于已报道的生于黑麦草上的另一个种Alternarialolii-temulenti(具长的分生孢子链)。和生于禾本科植物上的其它链格孢相比,该新种与Alternariajaponica和Alternariaoryzae一样具有相似的产孢型,但是新种的分生孢子细长,不同于后两者。新种模式标本保存在河南农业大学标本馆菌物分馆(HHAUF)。     

家鸽上纹状体视神经元对光刺激的反应特征

据文献报道,鸟类端脑有可能存在三个视觉代表区,上纹状体视区(Visual area in hyperstriatum)是其中之一。迄今虽在解剖学、生理学方面对上纹状体视区进行了一些研究,但有关视神经元对光刺激的反应特征却尚未见报道。本工作就家鸽上纹状体视神经元对光刺激的反应特征进行了研究。     

柽麻根瘤菌在非豆科作物体内的存活与繁殖

以根癌农杆菌(Agrobacterium tumefaciens)的DNA转化根瘤菌,使根瘤菌能在非豆科植物上形成肿瘤,早有报道;通过接合途径使根瘤菌获得根癌农杆菌的Ti质粒,进而在非豆科植物上形成肿瘤,近来也有报道。但一般     

早花基因在植物教学及遗传育种中的应用

不同植物在开花时间上总是存在一定的差异,这种差异有其本身的遗传基础,也与温度和(或)光周期有密切关系,这些性状可能以数学遗传或质量遗传方式遗传下去。深入研究表明植物均不同程度地存在早花基因,Gottschal和Wellensic报道了豆类中的早花基因,报道认为早花基因是隐性等位基因;Murfet报道了在豆类中的早花基因为一个显性一个隐性组成;Bernard报道了大豆的早花基因为两个隐性等位基因;Coyne和Mattson鉴别出了菜豆的三种开花时间基因;Pinihus报道了春小麦中的一个显性早花基因;Ttai讨论了水稻上的复杂开花基因,其早花基因是由在不同位点上的4     

小鳈的寄生指环虫二新种记述

鮈亚科Gobioninae鳈属Sarcocheilichthys鱼类是我国习见的小型鱼类。这属鱼类的寄生单殖吸虫,曾为Gussev(1955)在华鳈S.sinensis上报道过一个种Dacrylogycusnovicularis,吴宝华(1962)在其上又报道一种杭州锚首虫Ancyrocephalus hangchowensis,后一作者(1963)又在黑鳍鳈S.nigripinnis nigripinnis上发现一种黑鳍鲸锚首虫Ancyr,nigri-pinnis。在小鳈S.parvus Nichols上,至今尚未见有报道。1979—1980年,作者等在贵州东部该鱼鳃上采得两种寄生指环虫,经鉴定,均为新种,现描述于下。量度单位为毫米。     

湖南早石炭世海参化石

我国海参化石报道很少,自王成源(1979)首次报道了南京上二叠统的海参化石之后,笔者(1983,1985)报道了湖南中泥盆统一下石炭统的海参化石,丁惠(1985)报道了河南上石炭统的海参化石。此外,笔者还研究了贵州独山下石炭统上司组的海参化石。这些海参化石除了贵州独山上司组的海参化石是从黑色页岩中用15％的过氧化氢溶液分析处理得到之外,其余均是用弱醋酸处理碳酸盐岩时得到的。近几年来,随着海参     

Recent advances in the study of Kaposi's sarcoma-associated herpesvirus replication and pathogenesis

It has now been over twenty years since a novel herpesviral genome was identified in Kaposi's sarcoma biopsies. Since then, the cumulative research effort by molecular biologists, virologists, clinicians, and epidemiologists alike has led to the extensive characterization of this tumor virus, Kaposi's sarcoma-associated herpesvirus(KSHV; also known as human herpesvirus 8(HHV-8)), and its associated diseases. Here we review the current knowledge of KSHV biology and pathogenesis, with a particular emphasis on new and exciting advances in the field of epigenetics. We also discuss the development and practicality of various cell culture and animal model systems to study KSHV replication and pathogenesis.     

A Unique Protease Cleavage Site Predicted in the Spike Protein of the Novel Pneumonia Coronavirus (2019-nCoV) Potentially Related to Viral Transmissibility

正Dear Editor,In December 2019, a novel human coronavirus caused an epidemic of severe pneumonia(Coronavirus Disease 2019,COVID-19) in Wuhan, Hubei, China(Wu et al. 2020; Zhu et al. 2020). So far, this virus has spread to all areas of China and even to other countries. The epidemic has caused 67,102 confirmed infections with 1526 fatal cases     

Curcuminoids as inhibitors of thioredoxin reductase: A receptor based pharmacophore study with distance mapping of the active site

Curcumin is the yellow pigment of turmeric that interacts irreversibly forming an adduct with thioredoxin reductase (TrxR), an enzyme responsible for redox control of cell and defence against oxidative stress. Docking at both the active sites of TrxR was performed to compare the potency of three naturally occurring curcuminoids, namely curcumin, demethoxy curcumin and bis-demethoxy curcumin. Results show that active sites of TrxR occur at the junction of E and F chains. Volume and area of both cavities is predicted. It has been concluded by distance mapping of the most active conformations that Se atom of catalytic residue SeCYS498, is at a distance of 3.56 from C13 of demethoxy curcumin at the E chain active site, whereas C13 carbon atom forms adduct with Se atom of SeCys 498. We report that at least one methoxy group in curcuminoids is necessary for interation with catalytic residues of thioredoxin. Pharmacophore of both active sites of the TrxR receptor for curcumin and demethoxy curcumin molecules has been drawn and proposed for design and synthesis of most probable potent antiproliferative synthetic drugs.     

Synthesis and antimicrobial studies of hydrazone derivatives of 4-[3-(2,4-difluorophenyl)-4-formyl-1H-pyrazol-1-yl]benzoic acid and 4-[3-(3,4-difluorophenyl)-4-formyl-1H-pyrazol-1-yl]benzoic acid

Microbial resistance to antibiotics is an unresolved global concern, which needs urgent and coordinated action. One of the guidelines of the Centers for Disease Control and Preventions (CDC) to combat antibiotic resistance is the development of new antibiotics to treat drug-resistant bacteria. In our effort to find new antibiotics, we report the synthesis and antimicrobial studies of 30 new pyrazole derivatives. These novel molecules have been synthesized by using readily available starting materials and benign reaction conditions. Some of these molecules have shown activity with MIC values as low as 0.78?µg/mL against four bacterial strains; Staphylococcus aureus, methicillin-resistant S. aureus, Bacillus subtilis, and Acinetobacter baumannii. Furthermore, active molecules are non-toxic to mammalian cell line.

     

Comparative morphology of the carpel in the Liliaceae: Hewardieae, Petrosavieae, and Tricyrteae

The young pistils in the melanthioid tribes, Hewardieae, Petrosavieae and Tricyrteae, are uniformly tricarpellate and syncarpous. They lack raphide idioblasts. All are multiovulate, with bitegmic ovules. The Petrosavieae are marked by the presence of septal glands and incomplete syncarpy. Tepals and stamens adhere to the ovary in the Hewardieae and the Petrosavieae but not in the Tricyrteae. Two vascular bundles occur in the stamens of the Hewartlieae and Tricyrtis latifolia. Ventral bundles in the upper part of the ovary of the Hewardieae are continuous with compound septal bundles and placental bundles in the lower part. Putative ventral bundles occur in the alternate position in the Tricyrteae and putative placental bundles in the opposite. position in the Petrosavieae. The dichtomously branched stigma in each carpel of the Tricyrteae is supplied by a bifurcated dorsal bundle.     

Novel compounds with potent CDK9 inhibitory activity for the treatment of myeloma

Cyclin-dependent kinases (CDKs) and Polo-like kinases (PLKs) play key role in the regulation of the cell cycle. The aim of our study was originally the further development of our recently discovered polo-like kinase 1 (PLK1) inhibitors. A series of new 2,4-disubstituted pyrimidine derivatives were synthesized around the original hit, but their PLK1 inhibitory activity was very poor. However the novel compounds showed nanomolar CDK9 inhibitory activity and very good antiproliferative effect on multiple myeloma cell lines (RPMI-8226).