我国北方地区裸胞壳属(Emericeila)的种

对1402份来自于东北,华北及西北地区的土样进行裸胞壳属(Emericella)菌的分离．结合菌落形态及扫描电镜下子囊孢子的形态将各菌鉴定到种。结果表明我国北方地区分布有8个种,1个变种,分别是无冠裸胞壳(Emericella acristata)、皱折裸胞壳(Emericellacorrugata)、茴香裸胞壳(Ernericella foeniculicola)、宫治裸胞壳(Emericella miyajii)、构巢裸胞壳(Emericella nidulans vat．．Nidulans)、构巢裸胞壳宽脊变种(Emericella nidulans vat．Tara)、四脊裸胞壳(Emericella quadrilineata)、褶皱裸胞壳(Emericella rugulosa)及波状裸胞壳(Emericella undulata)。除银川地区以Emericella acristata为优势菌外,各地区以Emericella nidulans最为常见．文中对常见菌种进行了简要的概述,对在我国较少见的种进行了详细的描述和讨论。     

海南省裸伞属新种和中国新记录

本文报道了海南省裸伞属(Gymnopilus Karsten)的1个新种和3个中国新记录种。该新种为海南裸伞(Gymnopilus hainanensis T. H. Li et W. M. Zhang)。新记录种为栎裸伞(Gymnopilus dryophilus Murrill),厄尔裸伞(G. earlei Murrill)和细鳞裸伞(G. parvisquamulosus Hesler)。所有标本保藏于广东省微生物研究所真菌标本室(HMIGD)内。     

我国北方地区裸胞壳属（Emericella）的种

对１４０２份来自于东北,华北及西北地区的土样进行裸胞壳属菌的分离。结合菌落开矿的扫描电镜下囊孢子的形态将各菌鉴定到种。结果表明我国北方地区分布有８个种,１个变种,分别是无冠裸胞壳,皱折裸胞壳,茴香裸胞索,宫治裸胞壳,构巢裸胞索,褶皱裸皱胞壳及波状裸胞,四脊裸胞索,褶皱裸胞索及波状裸胞壳。     

中国毛壳菌科研究Ⅰ. ——毛壳菌属的种

报道了毛壳菌属的十一个种,旋丝毛壳 Chaetomium bostrychodes,反卷毛壳 C. convolutum,舟形毛壳 C. cymbiforme,高大毛壳 C. elatum,粪生毛壳 C. funicola,球孢毛壳 C. globosporum,球毛壳 C. globosum,细丽毛壳 C. gracile,六孢毛壳 C. hexagonosporum,印度毛壳 C. indicum和近缘毛壳C. subaffine。其中包括四个中国新记录种:舟形毛壳 C. cymbiforme,球孢毛壳 C. globosporum,六孢毛壳 C. hexagonosporum和近缘毛壳 C. subaffine。根据我国的标本和菌种对新记录种作了描述,并附了显微照片。标本与菌种保存在西北农林科技大学真菌标本室 (HMUABO)。     

我国北方地区裸胞壳属(Emericela)的种

对１４０２份来自于东北、华北及西北地区的土样进行裸胞壳属（Ｅｍｅｒｉｃｅｌａ）菌的分离。结合菌落形态及扫描电镜下子囊孢子的形态将各菌鉴定到种。结果表明我国北方地区分布有８个种,１个变种,分别是无冠裸胞壳（Ｅｍｅｒｉｃｅｌａａｃｒｉｓｔａｔａ）、皱折裸胞壳（４Ｅｍｅｒｉｃｅｌａｃｏｒｒｕｇａｔａ）、茴香裸胞壳（Ｅｍｅｒｉｃｅｌａｆｏｅｎｉｃｕｌｉｃｏｌａ）、宫治裸胞壳（Ｅｍｅｒｉｃｅｌａｍｉｙａｊｉ）、构巢裸胞壳（Ｅｍｅｒｉｃｅｌａｎｉｄｕｌａｎｓｖａｒ．ｎｉｄｕｌａｎｓ）、构巢裸胞壳宽脊变种（Ｅｍｅｒｉｃｅｌａｎｉｄｕｌａｎｓｖａｒ．ｌａｔａ）、四脊裸胞壳（Ｅｍｅｒｉｃｅｌａｑｕａｄｒｉｌｉｎｅａｔａ）、褶皱裸胞壳（Ｅｍｅｒｉｃｅｌａｒｕｇｕｌｏｓａ）及波状裸胞壳（Ｅｍｅｒｉｃｅｌａｕｎｄｕｌａｔａ）。除银川地区以Ｅｍｅｒｉｃｅｌａａｃｒｉｓｔａｔａ为优势菌外,各地区以Ｅｍｅｒｉｃｅｌａｎｉｄｕｌａｎｓ最为常见。文中对常见菌种进行了简要的概述,对在我国较少见的种进行了详细的描述和讨论     

中国南部地区松树上的散斑壳菌II．

在前一篇文章里,作者报告了我国南部地区松树上散斑壳属(LophodermiumChev)的8个种。本文继续报道7个种,其中广西散斑壳(L. guangxiense Y．R．Lin)是新种,东方散斑壳(L. orientale Minter)为我国新记录种,乔松散斑壳(L. pini-excelsaeAhmad)等5种为国内已知种。另外,编制了中国南部地区松树上散斑壳分种检索表。     

中国南部地区松树上的散斑壳菌I．

近年作者对我国南部地区松树上的散斑壳属(Lophodermium Chev．)真菌进行了调查和研究。本文报道8个种,其中椭圆散斑壳(L. ellipticum Y.R．Lin)是新种,喜马拉雅散斑壳(L. himalayense P．F．Cannon ＆ Minter)和库曼散斑壳(L. kumaunicum Minter ＆ M．P．Sharma) 为我国新记录种,南方散斑壳(L. australe Dearn.)等5种为国内已记载种。对新种作了拉丁文、汉文描述和图解,对新记录种进行了简要记述。另外,记载了已知种的寄主新记录和地理新分布。     

云南省可培养丝孢真菌资源的调查研究

本文报道曲霉属及其相关的有性型属、即散囊菌属和裸胞壳属的分类群共15个,其中新变种1个,我国新记录3个。它们是：日本曲霉小囊变种(新变种),赭曲霉,蜂蜜曲霉,孔曲霉,埋藏曲霉(新记录),佩特曲霉(新记录)、亮白曲霉,阿姆斯特丹散囊菌,谢瓦散囊菌,腊叶散囊菌,赤散囊菌,匍匐散囊菌原变种,构巢裸胞壳,无冠裸胞壳和刺孢裸胞壳(新记录)。     

中国叉丝壳属分类研究V．忍冬科上的新种和已知种

本文报道寄生于我国忍冬科植物上的叉丝壳属白粉菌5个种：双盾叉丝壳Micros-phaera dipeltae Yu et Lai sp．nov.,二郎山叉丝壳 M．Erlangshunensis Yu sp．nov., 忍冬叉丝壳 M．Loniccrae (De．)Winter,万布叉丝壳M．Van-brunetlana Gerard 和荚叉丝壳M. Riburni(Duby)Biumer,前二者为新种;对新种作了汉文和拉丁文描述,并附有形态图。每一个种都列有寄主种类和国内外分布,并讨论了它们与邻近种之间的区别。     

裸伞属的两个新种

本文报道了广东地区裸伞属(Gymnopilus Karsten)的7个种,其中2个新种,除近缘裸伞外,其余为国内新纪录。并附分种检索表。     

Recent advances in the study of Kaposi's sarcoma-associated herpesvirus replication and pathogenesis

It has now been over twenty years since a novel herpesviral genome was identified in Kaposi's sarcoma biopsies. Since then, the cumulative research effort by molecular biologists, virologists, clinicians, and epidemiologists alike has led to the extensive characterization of this tumor virus, Kaposi's sarcoma-associated herpesvirus(KSHV; also known as human herpesvirus 8(HHV-8)), and its associated diseases. Here we review the current knowledge of KSHV biology and pathogenesis, with a particular emphasis on new and exciting advances in the field of epigenetics. We also discuss the development and practicality of various cell culture and animal model systems to study KSHV replication and pathogenesis.     

A Unique Protease Cleavage Site Predicted in the Spike Protein of the Novel Pneumonia Coronavirus (2019-nCoV) Potentially Related to Viral Transmissibility

正Dear Editor,In December 2019, a novel human coronavirus caused an epidemic of severe pneumonia(Coronavirus Disease 2019,COVID-19) in Wuhan, Hubei, China(Wu et al. 2020; Zhu et al. 2020). So far, this virus has spread to all areas of China and even to other countries. The epidemic has caused 67,102 confirmed infections with 1526 fatal cases     

Curcuminoids as inhibitors of thioredoxin reductase: A receptor based pharmacophore study with distance mapping of the active site

Curcumin is the yellow pigment of turmeric that interacts irreversibly forming an adduct with thioredoxin reductase (TrxR), an enzyme responsible for redox control of cell and defence against oxidative stress. Docking at both the active sites of TrxR was performed to compare the potency of three naturally occurring curcuminoids, namely curcumin, demethoxy curcumin and bis-demethoxy curcumin. Results show that active sites of TrxR occur at the junction of E and F chains. Volume and area of both cavities is predicted. It has been concluded by distance mapping of the most active conformations that Se atom of catalytic residue SeCYS498, is at a distance of 3.56 from C13 of demethoxy curcumin at the E chain active site, whereas C13 carbon atom forms adduct with Se atom of SeCys 498. We report that at least one methoxy group in curcuminoids is necessary for interation with catalytic residues of thioredoxin. Pharmacophore of both active sites of the TrxR receptor for curcumin and demethoxy curcumin molecules has been drawn and proposed for design and synthesis of most probable potent antiproliferative synthetic drugs.     

Comparative morphology of the carpel in the Liliaceae: Hewardieae, Petrosavieae, and Tricyrteae

The young pistils in the melanthioid tribes, Hewardieae, Petrosavieae and Tricyrteae, are uniformly tricarpellate and syncarpous. They lack raphide idioblasts. All are multiovulate, with bitegmic ovules. The Petrosavieae are marked by the presence of septal glands and incomplete syncarpy. Tepals and stamens adhere to the ovary in the Hewardieae and the Petrosavieae but not in the Tricyrteae. Two vascular bundles occur in the stamens of the Hewartlieae and Tricyrtis latifolia. Ventral bundles in the upper part of the ovary of the Hewardieae are continuous with compound septal bundles and placental bundles in the lower part. Putative ventral bundles occur in the alternate position in the Tricyrteae and putative placental bundles in the opposite. position in the Petrosavieae. The dichtomously branched stigma in each carpel of the Tricyrteae is supplied by a bifurcated dorsal bundle.     

Synthesis and antimicrobial studies of hydrazone derivatives of 4-[3-(2,4-difluorophenyl)-4-formyl-1H-pyrazol-1-yl]benzoic acid and 4-[3-(3,4-difluorophenyl)-4-formyl-1H-pyrazol-1-yl]benzoic acid

Microbial resistance to antibiotics is an unresolved global concern, which needs urgent and coordinated action. One of the guidelines of the Centers for Disease Control and Preventions (CDC) to combat antibiotic resistance is the development of new antibiotics to treat drug-resistant bacteria. In our effort to find new antibiotics, we report the synthesis and antimicrobial studies of 30 new pyrazole derivatives. These novel molecules have been synthesized by using readily available starting materials and benign reaction conditions. Some of these molecules have shown activity with MIC values as low as 0.78?µg/mL against four bacterial strains; Staphylococcus aureus, methicillin-resistant S. aureus, Bacillus subtilis, and Acinetobacter baumannii. Furthermore, active molecules are non-toxic to mammalian cell line.

     

Novel compounds with potent CDK9 inhibitory activity for the treatment of myeloma

Cyclin-dependent kinases (CDKs) and Polo-like kinases (PLKs) play key role in the regulation of the cell cycle. The aim of our study was originally the further development of our recently discovered polo-like kinase 1 (PLK1) inhibitors. A series of new 2,4-disubstituted pyrimidine derivatives were synthesized around the original hit, but their PLK1 inhibitory activity was very poor. However the novel compounds showed nanomolar CDK9 inhibitory activity and very good antiproliferative effect on multiple myeloma cell lines (RPMI-8226).