用ID-SVM预测蛋白质的ATP结合位点

从蛋白质序列出发,对经Dr．G．P．S．Raghava整理和使用过的168条非冗余的ATP与蛋白质结合氨基酸序列进行分段,对ATP与蛋白质结合位点进行了统计分析。在此基础上,利用20种氨基酸的亲疏水性将20种氨基酸约化为6类。以氨基酸组分和6类亲疏水紧邻为参数,用多样性增量（ID）方法将氨基酸组分和6类亲疏水紧邻降维并将降维后的特征参数输入支持向量机中运算,本文运算结果显示用氨基酸组分ID值和6类亲疏水紧邻ID值共同作为特征参数结果最优,在七交叉检验下的预测总精度达到了99．67％,相关系数达到0．9934,好于前人的预测结果。     

基于模糊支持向量机的膜蛋白折叠类型预测

现有的基于支持向量机（support vector machine,SVM）来预测膜蛋白折叠类型的方法．利用的蛋白质序列特征并不充分．并且在处理多类蛋白质分类问题时存在不可分区域,针对这两类问题．提取蛋白质序列的氨基酸和二肽组成特征,并计算加权的多阶氨基酸残基指数相关系数特征,将3类特征融和作为分类器的输入特征矢量．并采用模糊SVM（fuzzy SVM,FSVM）算法解决对传统SVM不可分数据的分类．在无冗余的数据集上测试结果显示．改进的特征提取方法在相同分类算法下预测性能优于已有的特征提取方法：FSVM在相同特征提取方法下性能优于传统的SVM．二者相结合的分类策略在独立性数据集测试下的预测精度达到96．6％．优于现有的多种预测方法．能够作为预测膜蛋白和其它蛋白质折叠类型的有效工具．     

《猪毛制备氨基酸》简介

<正>《猪毛制备氨基酸》是武汉大学生物系编写的一本氨基酸生产技术资料专集。约20万字。第一篇为《氨基酸的制备》。共分六章,分别介绍了胱氨酸、精氨酸、谷氨酸、亮氨酸、半胱氨酸盐酸盐和N-乙酰半胱氨酸等7种氨基酸的制备方法和检验方法。第二篇为《氨基酸的化学、分类及应用》,共分三章,第一章介绍了氨基酸的化学性质和物理性质。第二章对常见的二十种氨基酸进行了分类,逐个介绍了     

《猪毛制备氨基酸》简介

《猪毛制备氨基酸》是武汉大学生物系编写的一本氨基酸生产技术资料专集。约20万字。第一篇为《氨基酸的制备》。共分六章,分别介绍了胱氨酸、精氨酸、谷氨酸、亮氨酸、半胱氨酸盐酸盐和N-乙酰半胱氨酸等7种氨基酸的制备方法和检验方法。第二篇为《氨基酸的化学、分类及应用》,共分三章,第一章介绍了氨基酸的化学性质和物理性质。第二章对常见的二十种氨基酸进行了分类,逐个介绍了制备方法、     

《猪毛制备氨基酸》简介

《猪毛制备氨基酸》是武汉大学生物系编写的一本氨基酸生产技术资料专集。约20万字。第一篇为《氨基酸的制备》。共分六章,分别介绍了胱氨酸、精氨酸、谷氨酸、亮氨酸、半胱氨酸盐酸盐和N-乙酰半胱氨酸等7种氨基酸的制备方法和检验方法。第二篇为《氨基酸的化学、分类及应用》,共分三章,第一章介绍了氨基酸的化学性质和物理性质。第二章对常见的二十种氨基酸进行了分类,     

《猪毛制备氨基酸》简介

《猪毛制备氨基酸》是武汉大学生物系编写的一本氨基酸生产技术资料专集。约20万字。第一篇为《氨基酸的制备》。共分六章,分别介绍了胱氨酸、精氨酸、谷氨酸、亮氨酸、半胱氨酸盐酸盐和N-乙酰半胱氨酸等7种氨基酸的制备方法和检验方法。第二篇为《氨基酸的化学、分类及应用》,共分三章,第一章介绍了氨基酸的化学性质和物理性质。第二章对常见的二十种氨基酸进行了分类,逐个介绍了制备方法、性质及检验方法。第三章介绍了氨基酸广泛应用于医药、食品、工业和农业领域情况。该书有以下几个显著特点：     

苏云金芽胞杆菌杀虫晶体蛋白基因的分类

１９８９年Ｈｏｆｔｅ和Ｗｈｉｔｅｌｅｙ根据氨基酸序列的同源性和杀虫谱双重标准将苏云金芽胞杆菌杀虫晶体蛋白基因划分为５类１４亚类。根据双重标准出现的问题和冲突,给分类带来了困扰,为此１９９５年,只根据氨基酸序列的同源性进行分类。现已将基因分为２１群,４４亚群,６４类,１１６个亚类。本文介绍了纳入新系统的条件、分类原则、命名方法、定名步骤和分类中值得注意的问题。     

《猪毛制备氨基酸》简介

《猪毛制备氨基酸》是武汉大学生物系编写的一本氨基酸生产技术资料专集。约20万字。第一篇为《氨基酸的制备》。共分六章,分别介绍了胱氨酸、精氨酸、谷氨酸、亮氨酸、半胱氨酸盐酸盐和N-乙酰半胱氨酸等7种氨基酸的制备方法和检验方法。第二篇为《氨基酸的化学、分类及应用》,共分三章,第一章介绍了氨基酸的化学性质和物理性质。第二章对常见的二十种氨基酸进行了分类,逐个介绍了制备方法、性质及检验方法。第三章介绍了氨基酸广泛应用于医药、食品、工业和农业领域情况。     

《猪毛制备氨基酸》简介

《猪毛制备氨基酸》是武汉大学生物系编写的一本氨基酸生产技术资料专集。约20万字。第一篇为《氨基酸的制备》。共分六章,分别介绍了胱氨酸、精氨酸、谷氨酸、亮氨酸、半胱氨酸盐酸盐和N-乙酰半胱氨酸等7种氨基酸的制备方法和检验方法。第二篇为《氨基酸的化学、分类及应用》,共分三章,第一章介绍了氨基酸的化学性质和物理性质。第二章对常见的二十种氨基酸进行了分类,逐个介绍了制备方法、性质及检验方法。第三章介绍了氨基酸广泛应用于医药、食品、工业和农业领域情况。该书有以下几个显著特点：     

《猪毛制备氨基酸》简介

《猪毛制备氨基酸》是武汉大学生物系编写的一本氨基酸生产技术资料专集。约20万字。第一篇为《氨基酸的制备》。共分六章,分别介绍了胱氨酸、精氨酸、谷氨酸、亮氨酸、半胱氨酸盐酸盐和N-乙酰半胱氨酸等7种氨基酸的制备方法和检验方法。第二篇为《氨基酸的化学、分类及应用》,     

Recent advances in the study of Kaposi's sarcoma-associated herpesvirus replication and pathogenesis

It has now been over twenty years since a novel herpesviral genome was identified in Kaposi's sarcoma biopsies. Since then, the cumulative research effort by molecular biologists, virologists, clinicians, and epidemiologists alike has led to the extensive characterization of this tumor virus, Kaposi's sarcoma-associated herpesvirus(KSHV; also known as human herpesvirus 8(HHV-8)), and its associated diseases. Here we review the current knowledge of KSHV biology and pathogenesis, with a particular emphasis on new and exciting advances in the field of epigenetics. We also discuss the development and practicality of various cell culture and animal model systems to study KSHV replication and pathogenesis.     

A Unique Protease Cleavage Site Predicted in the Spike Protein of the Novel Pneumonia Coronavirus (2019-nCoV) Potentially Related to Viral Transmissibility

正Dear Editor,In December 2019, a novel human coronavirus caused an epidemic of severe pneumonia(Coronavirus Disease 2019,COVID-19) in Wuhan, Hubei, China(Wu et al. 2020; Zhu et al. 2020). So far, this virus has spread to all areas of China and even to other countries. The epidemic has caused 67,102 confirmed infections with 1526 fatal cases     

Curcuminoids as inhibitors of thioredoxin reductase: A receptor based pharmacophore study with distance mapping of the active site

Curcumin is the yellow pigment of turmeric that interacts irreversibly forming an adduct with thioredoxin reductase (TrxR), an enzyme responsible for redox control of cell and defence against oxidative stress. Docking at both the active sites of TrxR was performed to compare the potency of three naturally occurring curcuminoids, namely curcumin, demethoxy curcumin and bis-demethoxy curcumin. Results show that active sites of TrxR occur at the junction of E and F chains. Volume and area of both cavities is predicted. It has been concluded by distance mapping of the most active conformations that Se atom of catalytic residue SeCYS498, is at a distance of 3.56 from C13 of demethoxy curcumin at the E chain active site, whereas C13 carbon atom forms adduct with Se atom of SeCys 498. We report that at least one methoxy group in curcuminoids is necessary for interation with catalytic residues of thioredoxin. Pharmacophore of both active sites of the TrxR receptor for curcumin and demethoxy curcumin molecules has been drawn and proposed for design and synthesis of most probable potent antiproliferative synthetic drugs.     

The structure, reproduction and taxonomy of Vidalia and Osmundaria (Rhodophyta, Rhodomelaceae)

Comprises species occurring mostly in subtidal habitats in tropical, subtropical and warm-temperate areas of the world. An analysis of the type species, V. spiralis (Sonder) Lamouroux ex J. Agardh, a species from Australia, establishes basic characters for distinguishing species in the genus. These characters are (1) branching patterns of thalli, (2) flat blades that may be spiralled on their axis, (3) width of the blade, (4) primary or secondary derivation of sterile and fertile branchlets and (5) position of sterile and fertile branchlets on the thalli. Application of the latter two characters provides an important basic method for separation of species into three major groups. Osmundaria , a genus known only in southern Australia, was studied in relation to Vidalia , and its separation from the Vidalia assemblage is not accepted. Species of Vidalia therefore are transferred to the older genus name, Osmundaria. Two new species, Osmundaria papenfussii and Osmundaria oliveae are described from Natal. Confusion in the usage of the epithet, Vidalia fimbriala Brown ex Turner has been clarified, and Vidalia gregaria Falkenberg, described as an epiphyte on Osmundaria pro/ifera Lamouroux, is revealed to be young branches of the host, Osmundaria prolifera.     

New or rare chromosome counts in Artemisia L. (Asteraceae, Anthemideae) and related genera from Kazakhstan

Fifteen chromosome counts of six Artemisia taxa and one species of each of the genera Brachanthemum, Hippolytia, Kaschgaria, Lepidolopsis and Turaniphytum are reported from Kazakhstan. Three of them are new reports, two are not consistent with previous counts and the remainder are confirmations of very scarce (one to four) earlier records. All the populations studied have the same basic chromosome number, x = 9, with ploidy levels ranging from 2x to 6x. Some correlations between ploidy level, morphological characters and distribution are noted.