中国平颜三节叶蜂属分类研究(膜翅目: 三节叶蜂科)

记述了膜翅目三节叶蜂科平颜三节叶蜂属Aprosthema Konow 3新种: 双斑平颜三节叶蜂Aprosthema bimaculata Wei et Wen sp. Nov., 黑背平颜三节叶蜂Aprosthema nigroscutis Wei et Wen sp. Nov. 和天目平颜三节叶蜂Aprosthema tianmunica Wei et Wen sp. Nov..新种模式标本均保存在中南林学院资源与环境学院模式昆虫标本室.     

中国三节叶蜂属(膜翅目,三节叶蜂科)一新种及Arge xanthogaster种团东亚种类检索表(英文)

记述采自记述中国三节叶蜂科三节叶蜂属1新种:白尾晴腹三节叶蜂Arge albocaudalica Wei,Yan et He.sp.nov..本种与Arge xanthogaster (Cameron,1876)很相似,但腹部黑褐色,端部2节背板和锯鞘黄白色;后翅臀窒柄短于后翅M室长,锯鞘背面观内侧切口很小,深度明显短于锯鞘侧叶端部宽;锯腹片14刃,第2节缝最长粗刺毛约等长于锯节宽度的3/4,节缝粗毛每节约9个,第8节缝最长粗刺毛等宽于该处锯节宽.定义了Arge xanthogaster种团,编制了该种团东亚地区已知种类检索表.     

中国叶蜂亚科二新种(膜翅目,叶蜂科)

记述中国叶蜂亚科2新种:孙氏金蓝叶蜂Metallopeus sunae Wei et Zhang,sp.nov.和光额横带叶蜂 Tenthredo nitidifrontalia Wei et Zhang,sp.nov.前者隶属于金蓝叶蜂属Metallopeus Malaise,1934,后者隶属于叶蜂属Tenthredo Linnaeus,1758的横带叶蜂种团T.pompilina group.金蓝叶蜂属的分布纪录向北延伸约10个纬度.     

中国叶蜂属(膜翅目,叶蜂科)三新种

记述采自中国河南、陕西、浙江的叶蜂科叶蜂亚科叶蜂属3新种:吕氏横斑叶蜂Tenthredo lunani Wei et Niu,sp.nov.,三斑槌腹叶蜂Tenthredo dolichomisca Wei et Niu,sp.nov.,黑腰白端叶蜂Tenthredo pararubiapicilina Wei et Niu,sp.nov.。新种模式标本保存于湖南长沙中南林业科技大学昆虫模式标本室。     

中国蕨叶蜂亚科三新种(膜翅目,叶蜂科)

记述中国蕨叶蜂亚科3新种:美斑长片叶蜂Neothrinax formosula Wei et Xiao,sp.nov,.糙眶侧齿叶蜂Neostromboceros punctiorbita Wei et Xiao,sp.nov和.周氏侧齿叶蜂Neostromboceros zhousyi Wei et Liu,sp.nov。.     

中国大基叶蜂亚科三新种(膜翅目,叶蜂科)

记述中国大基叶蜂亚科3新种:宽斑大基叶蜂Beleses latimaculatus Wei et Niu,sp.nov.,黑毛大基叶蜂Beleses nigropilosus Wei et Niu,sp.nov.和黄褐凹跗叶蜂Eusunoxa fulvitarsis Wei et Xue,sp.nov.。     

中国方颜叶蜂属(膜翅目,叶蜂科)种团二新种

记述方颜叶蜂属Pachyprotasis pallidistigma种团2新种:周氏方颜叶蜂Pachyprotasis zhoui Wei et Zhong,sp. nov.和稻城方颜叶蜂Pachyprotasis daochengensis Wei et Zhong, sp. nov..新种模式标本保存在中南林业科技大学昆虫模式标本室.     

中国三节叶蜂属一新种(膜翅目,三节叶蜂科)

记述中国三节叶蜂科三节叶蜂属1新种,长颊黑毛三节叶蜂Arge dolichogenata Wei et Nie,sp.nov..新种与Arge gracilicornis(Klug,1814)近似,但体型显著较大,体长9～10 mm;触角明显粗壮,短于中胸;颜面和内眶刻点粗密,侧脊弧形弯曲,额窝深,额脊显著;前翅2Rs室几乎等长于1Rs室,Rs脉第3段2倍于Rs第4段长,前后翅Cu<,2脉桩显著;雌虫锯腹片锯刃强烈突出;雄虫下生殖板端部宽截形,阳茎瓣头叶较宽,尾突窄长,腹侧中钩长且向上勾曲.新种模式标本保存于中南林业科技大学昆虫模式标本室.?＃     

中国叶蜂属(膜翅目,叶蜂科)两新种

记述中国叶蜂科叶蜂属2新种:平突翠绿叶蜂Tenthredo flatotrunca Wei et Hu,sp.nov.和角斑长突叶蜂Tenthredo triangulimacula Wei et Hu,sp.nov..前者属于叶蜂属翠绿叶蜂种团Tenthredo trunca group,后者属于叶蜂属长突叶蜂种团Tenthredo triangulifera group.简要讨论了翠绿叶蜂种团和长突叶蜂种团的特征与种类分布状况.提供了长突叶蜂种团分种检索表.新种模式标本保存于湖南长沙中南林业科技大学昆虫模式标本室.     

中国叶蜂属(膜翅目,叶蜂科)OBSOLETA-MESOMELA种团二新种

记述采自中国境内叶蜂属obsoleta-mesomela种团2新种:粗纹窄突叶蜂Tenthredo paraobsoleta Wei et Liu,sp.nov.和粗纹低突叶蜂Tenthredo pseudomesomela Wei et Li,sp.nov..前者属于obsoleta亚种团,后者属于mesomela亚种团.新种模式标本保存于湖南长沙中南林业科技大学昆虫模式标本室.     

Recent advances in the study of Kaposi's sarcoma-associated herpesvirus replication and pathogenesis

It has now been over twenty years since a novel herpesviral genome was identified in Kaposi's sarcoma biopsies. Since then, the cumulative research effort by molecular biologists, virologists, clinicians, and epidemiologists alike has led to the extensive characterization of this tumor virus, Kaposi's sarcoma-associated herpesvirus(KSHV; also known as human herpesvirus 8(HHV-8)), and its associated diseases. Here we review the current knowledge of KSHV biology and pathogenesis, with a particular emphasis on new and exciting advances in the field of epigenetics. We also discuss the development and practicality of various cell culture and animal model systems to study KSHV replication and pathogenesis.     

A Unique Protease Cleavage Site Predicted in the Spike Protein of the Novel Pneumonia Coronavirus (2019-nCoV) Potentially Related to Viral Transmissibility

正Dear Editor,In December 2019, a novel human coronavirus caused an epidemic of severe pneumonia(Coronavirus Disease 2019,COVID-19) in Wuhan, Hubei, China(Wu et al. 2020; Zhu et al. 2020). So far, this virus has spread to all areas of China and even to other countries. The epidemic has caused 67,102 confirmed infections with 1526 fatal cases     

Curcuminoids as inhibitors of thioredoxin reductase: A receptor based pharmacophore study with distance mapping of the active site

Curcumin is the yellow pigment of turmeric that interacts irreversibly forming an adduct with thioredoxin reductase (TrxR), an enzyme responsible for redox control of cell and defence against oxidative stress. Docking at both the active sites of TrxR was performed to compare the potency of three naturally occurring curcuminoids, namely curcumin, demethoxy curcumin and bis-demethoxy curcumin. Results show that active sites of TrxR occur at the junction of E and F chains. Volume and area of both cavities is predicted. It has been concluded by distance mapping of the most active conformations that Se atom of catalytic residue SeCYS498, is at a distance of 3.56 from C13 of demethoxy curcumin at the E chain active site, whereas C13 carbon atom forms adduct with Se atom of SeCys 498. We report that at least one methoxy group in curcuminoids is necessary for interation with catalytic residues of thioredoxin. Pharmacophore of both active sites of the TrxR receptor for curcumin and demethoxy curcumin molecules has been drawn and proposed for design and synthesis of most probable potent antiproliferative synthetic drugs.     

Synthesis and antimicrobial studies of hydrazone derivatives of 4-[3-(2,4-difluorophenyl)-4-formyl-1H-pyrazol-1-yl]benzoic acid and 4-[3-(3,4-difluorophenyl)-4-formyl-1H-pyrazol-1-yl]benzoic acid

Microbial resistance to antibiotics is an unresolved global concern, which needs urgent and coordinated action. One of the guidelines of the Centers for Disease Control and Preventions (CDC) to combat antibiotic resistance is the development of new antibiotics to treat drug-resistant bacteria. In our effort to find new antibiotics, we report the synthesis and antimicrobial studies of 30 new pyrazole derivatives. These novel molecules have been synthesized by using readily available starting materials and benign reaction conditions. Some of these molecules have shown activity with MIC values as low as 0.78?µg/mL against four bacterial strains; Staphylococcus aureus, methicillin-resistant S. aureus, Bacillus subtilis, and Acinetobacter baumannii. Furthermore, active molecules are non-toxic to mammalian cell line.

     

Comparative morphology of the carpel in the Liliaceae: Hewardieae, Petrosavieae, and Tricyrteae

The young pistils in the melanthioid tribes, Hewardieae, Petrosavieae and Tricyrteae, are uniformly tricarpellate and syncarpous. They lack raphide idioblasts. All are multiovulate, with bitegmic ovules. The Petrosavieae are marked by the presence of septal glands and incomplete syncarpy. Tepals and stamens adhere to the ovary in the Hewardieae and the Petrosavieae but not in the Tricyrteae. Two vascular bundles occur in the stamens of the Hewartlieae and Tricyrtis latifolia. Ventral bundles in the upper part of the ovary of the Hewardieae are continuous with compound septal bundles and placental bundles in the lower part. Putative ventral bundles occur in the alternate position in the Tricyrteae and putative placental bundles in the opposite. position in the Petrosavieae. The dichtomously branched stigma in each carpel of the Tricyrteae is supplied by a bifurcated dorsal bundle.     

Novel compounds with potent CDK9 inhibitory activity for the treatment of myeloma

Cyclin-dependent kinases (CDKs) and Polo-like kinases (PLKs) play key role in the regulation of the cell cycle. The aim of our study was originally the further development of our recently discovered polo-like kinase 1 (PLK1) inhibitors. A series of new 2,4-disubstituted pyrimidine derivatives were synthesized around the original hit, but their PLK1 inhibitory activity was very poor. However the novel compounds showed nanomolar CDK9 inhibitory activity and very good antiproliferative effect on multiple myeloma cell lines (RPMI-8226).