活动半月板单髁关节置换术治疗膝骨性关节炎早期疗效分析

目的：分析活动半月板单髁关节置换术治疗膝关节骨关节炎的早期临床效果。方法：2009年6月至2010年2月,采用OXFord活动半月板单髁关节治疗膝骨性关节炎患者23例25膝。结果：23例患者（25膝）随访3-8个月,无感染、假体位置不良及松动等并发症。HSS评分由术前56.9分提高至术后93.3分。结论：活动半月板单髁关节置换术治疗膝骨性关节炎短期疗效优良,成功的关键在于适应证的把握和手术技术的掌握,其远期疗效仍需观察。     

医用臭氧与玻璃酸钠治疗骨关节炎的效果对比

目的探讨医用臭氧与玻璃酸钠治疗骨关节炎的临床效果对比。方法选取2017年1～12月我院收治的骨关节炎患者64例,按随机数字表法分为观察组和对照组各32例。观察组给予医用臭氧治疗,对照组给予玻璃酸钠治疗,观察比较两组治疗前后的临床疗效,视觉模拟量表(VAS)与Lysholm膝关节评分。结果治疗后1周、3个月及6个月,观察组患者的VAS评分低于对照组,Lysholm膝关节评分高于对照组,差异均有统计学意义(P0.05);观察组的总有效率明显高于对照组,差异有统计学意义(P0.05)。结论医用臭氧与玻璃酸钠在膝骨性关节炎治疗中均具有显著疗效,但臭氧的治疗效果更为显著,能有效缓解患者疼痛,促进膝关节功能恢复,提高治疗效果,值得临床推广。     

培元固本大膏药配合按摩牵引康复手法治疗膝骨关节炎60例

观察培元固本膏药配合按摩牵引康复手法治疗膝骨关节炎60例临床疗效。方法选取60例来我科就诊的膝骨关节炎患者。辩证诊治后给予中药内服,同时结合中药熏蒸、中药离子导入等外治控制病情后,在患者膝关节附近取穴梁丘、血海、犊鼻、阳陵泉腧穴上,采用悬灸灸法交替艾灸30分钟,后贴敷培元固本大膏药于关节外表面,并由康复人员进行康复手法治疗,康复手法方法为手法牵引、弹拨类手法施予病变部位的经络与腧穴。治疗疗程为4W。4W后依据Lysholm膝关节功能评分标准进行临床评价。分为显效(70分),进步(51~70分);改善(31~50分),无效(30分以下)。前三者合称为有效。结果 4W后显效者36例,进步者12例,有效者10例,无效2例。结论:培元固本膏药配合按摩牵引康复手法治疗膝骨关节炎临床疗效较好,值得推荐。     

膝骨性关节炎关节镜下分级治疗的临床应用

目的:探索膝关节骨性关节炎关节镜下分期及治疗的临床意义及效果。方法:将74例81膝骨性关节炎应用自行设计的关节镜下分级方法分为4级,并分别手术进行术后疗效观察。结果:1级21膝,优良率100%;2级23膝,优良率78.26%;3级25膝,优良率56%;4级12膝,优良率33.33%。结果 Wilcoxon秩检验,T=4.84,P<0.05,差异有显著性。结论:膝骨关节炎关节镜下分级,对于关节镜治疗膝关节骨性关节炎疗效差异显著。有助于手术适应症掌握,规范程序,避免手术盲目性及不必要损伤。     

活动半月板单髁关节置换术治疗膝骨性关节炎早期疗效分析

目的:分析活动半月板单髁关节置换术治疗膝关节骨关节炎的早期临床效果。方法:2009年6月至2010年2月,采用OXFord活动半月板单髁关节治疗膝骨性关节炎患者23例25膝。结果:23例患者(25膝)随访3-8个月,无感染、假体位置不良及松动等并发症。HSS评分由术前56.9分提高至术后93.3分。结论:活动半月板单髁关节置换术治疗膝骨性关节炎短期疗效优良,成功的关键在于适应证的把握和手术技术的掌握,其远期疗效仍需观察。     

骨关节炎Ⅰ号方外敷治疗膝OA 34例

本人自 1 999年 1 1月以来采用自拟骨关节炎 号方外敷治疗膝关节炎 ( OA) ,获得一定疗效 ,现报道如下。1　临床资料1 .1　一般资料　 34例患者中 ,男 1 2例 ,女 2 2例 ;年龄 46～ 78岁 ,平均年龄 62岁 ;平均病程 2 .5年 ;原发性 OA2 7例 ,继发性 OA7例。1 .2　诊断标准　 ( 1 )膝关节肿胀 ,疼痛 ,休息痛 ,活动后减轻、活动过度加重 ,膝关节活动不灵活 ,久坐、久站或休息后不能立即活动 ,自觉关节僵硬 ,走动及放松肌肉后方感活动自如。 ( 2 )膝关节轻度肿胀 ,骨摩擦或触按时有酸痛。 ( 3) X线检查示膝关节骨质增生 ,关节间隙变窄 ,软骨下…     

消肿止痛散外敷治疗急性肿胀期膝骨关节炎临床疗效显著

本研究选取贵州省中医医院100名急性期膝骨关节炎患者为研究对象,分为消肿止痛散治疗组和西医治疗组(扶他林乳胶剂)各50名,分类观测膝关节Baily评分、关节液中PGE2和IL-β的含量及治疗前后膝关节周径变化,以评价其临床疗效,以揭示消肿止痛散应用在膝骨关节炎急性肿胀期治疗中的消肿止痛作用。研究发现,治疗组中17例临床控制,20例显效,8例有效,5例无效,总有效率为90.00%(45/50);对照组中8例临床控制,18例显效,12例有效,12例无效,总体有效率76.00%(38/50)。本研究初步结论表明,消肿止痛散外敷治疗急性肿胀期膝关节炎临床疗效显著,副作用少,操作简便,值得临床推广应用。     

痛风性膝关节炎的关节镜诊疗价值分析

目的：探讨膝痛风性关节炎的关节镜治疗的临床疗效。方法：选取我院2006年至2009年共35例单膝痛风性关节炎患者,’喀随机分为2组：A组22例,给予药物治疗,同时行关节镜下检查及清理术;B组13例,仅给予药物治疗。观察比较两组患者膝关节Lysholm评分、疼痛VAS评分,关节活动度ROM改善情况。结果：关节镜治疗组22例病例中无关节镜手术并发症发生,关节镜治疗组在Lysholm、VAS评分和关节活动度ROM方面明显优于药物治疗组。结论：膝痛风性关节炎关节镜下有较显著的特点,膝关节镜下清理术治疗膝痛风性关节炎具有良好疗效,为药物治疗膝痛风性关节炎提供了良好的辅助治疗方法。     

人膝骨关节炎软骨下骨OPN的表达及其意义

目的：通过检测人膝骨关节炎裸露软骨下骨中OPN的表达,探讨OPN在OA发病及病情进展中的意义。方法：选取接受膝关节置换手术的膝关节骨关节炎患者软骨下骨标本50例,采用综合评分法对OA患者进行严重程度分级,分为轻、中、重度三组,取正常膝关节软骨下骨（股骨髁关节面）10例作为正常软骨下骨对照;对标本进行免疫组织化学染色,用SPSS17．0统计软件包分析各组间OPN表达的差异及OA患者OPN表达与综合评分、K-L分期的相关性。结果：人膝骨关节炎裸露软骨下骨OPN表达明显高于正常软骨下骨组,差异有统计学意义（P〈0．01）;OPN在轻、中、重度膝骨关节炎裸露软骨下骨的表达差异有统计学意义（P〈0．05）;膝骨关节炎裸露软骨下骨OPN的表达与骨关节炎的综合评分、K—L分期呈正相关。结论：OA患者膝关节软骨下骨OPN表达与疾病严重程度呈正相关,提示OPN在骨关节炎发病及病情进展中可能起作用。     

降钙素治疗膝骨关节炎的疗效观察

目的:观察和评价应用密盖息治疗膝骨关节炎的疗效.方法:40例女性病人,年龄50-75岁,平均年龄65岁,均经过临床X线检查确诊,应用密盖息四周后,对疼痛缓解时间、功能恢复情况进行疗效评估,并经一年门诊随访,总结其疗效.结果:随访1年后,统计达到优20例,良17例,无效3例,总有效率80%以上.结论:密盖息对膝骨关节炎治疗达到止痛、控制和预防膝骨关节内翻、外翻畸形,在临床治疗提高疗效起到巨大的作用.     

Recent advances in the study of Kaposi's sarcoma-associated herpesvirus replication and pathogenesis

It has now been over twenty years since a novel herpesviral genome was identified in Kaposi's sarcoma biopsies. Since then, the cumulative research effort by molecular biologists, virologists, clinicians, and epidemiologists alike has led to the extensive characterization of this tumor virus, Kaposi's sarcoma-associated herpesvirus(KSHV; also known as human herpesvirus 8(HHV-8)), and its associated diseases. Here we review the current knowledge of KSHV biology and pathogenesis, with a particular emphasis on new and exciting advances in the field of epigenetics. We also discuss the development and practicality of various cell culture and animal model systems to study KSHV replication and pathogenesis.     

A Unique Protease Cleavage Site Predicted in the Spike Protein of the Novel Pneumonia Coronavirus (2019-nCoV) Potentially Related to Viral Transmissibility

正Dear Editor,In December 2019, a novel human coronavirus caused an epidemic of severe pneumonia(Coronavirus Disease 2019,COVID-19) in Wuhan, Hubei, China(Wu et al. 2020; Zhu et al. 2020). So far, this virus has spread to all areas of China and even to other countries. The epidemic has caused 67,102 confirmed infections with 1526 fatal cases     

Curcuminoids as inhibitors of thioredoxin reductase: A receptor based pharmacophore study with distance mapping of the active site

Curcumin is the yellow pigment of turmeric that interacts irreversibly forming an adduct with thioredoxin reductase (TrxR), an enzyme responsible for redox control of cell and defence against oxidative stress. Docking at both the active sites of TrxR was performed to compare the potency of three naturally occurring curcuminoids, namely curcumin, demethoxy curcumin and bis-demethoxy curcumin. Results show that active sites of TrxR occur at the junction of E and F chains. Volume and area of both cavities is predicted. It has been concluded by distance mapping of the most active conformations that Se atom of catalytic residue SeCYS498, is at a distance of 3.56 from C13 of demethoxy curcumin at the E chain active site, whereas C13 carbon atom forms adduct with Se atom of SeCys 498. We report that at least one methoxy group in curcuminoids is necessary for interation with catalytic residues of thioredoxin. Pharmacophore of both active sites of the TrxR receptor for curcumin and demethoxy curcumin molecules has been drawn and proposed for design and synthesis of most probable potent antiproliferative synthetic drugs.     

The structure, reproduction and taxonomy of Vidalia and Osmundaria (Rhodophyta, Rhodomelaceae)

Comprises species occurring mostly in subtidal habitats in tropical, subtropical and warm-temperate areas of the world. An analysis of the type species, V. spiralis (Sonder) Lamouroux ex J. Agardh, a species from Australia, establishes basic characters for distinguishing species in the genus. These characters are (1) branching patterns of thalli, (2) flat blades that may be spiralled on their axis, (3) width of the blade, (4) primary or secondary derivation of sterile and fertile branchlets and (5) position of sterile and fertile branchlets on the thalli. Application of the latter two characters provides an important basic method for separation of species into three major groups. Osmundaria , a genus known only in southern Australia, was studied in relation to Vidalia , and its separation from the Vidalia assemblage is not accepted. Species of Vidalia therefore are transferred to the older genus name, Osmundaria. Two new species, Osmundaria papenfussii and Osmundaria oliveae are described from Natal. Confusion in the usage of the epithet, Vidalia fimbriala Brown ex Turner has been clarified, and Vidalia gregaria Falkenberg, described as an epiphyte on Osmundaria pro/ifera Lamouroux, is revealed to be young branches of the host, Osmundaria prolifera.     

New or rare chromosome counts in Artemisia L. (Asteraceae, Anthemideae) and related genera from Kazakhstan

Fifteen chromosome counts of six Artemisia taxa and one species of each of the genera Brachanthemum, Hippolytia, Kaschgaria, Lepidolopsis and Turaniphytum are reported from Kazakhstan. Three of them are new reports, two are not consistent with previous counts and the remainder are confirmations of very scarce (one to four) earlier records. All the populations studied have the same basic chromosome number, x = 9, with ploidy levels ranging from 2x to 6x. Some correlations between ploidy level, morphological characters and distribution are noted.