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排序方式: 共有223条查询结果,搜索用时 31 毫秒
1.
Giulia Bernardini Gemma Leone Lia Millucci Marco Consumi Daniela Braconi Ottavia Spiga Silvia Galderisi Barbara Marzocchi Cecilia Viti Giovanna Giorgetti Pietro Lupetti Agnese Magnani Annalisa Santucci 《Journal of cellular physiology》2019,234(5):6696-6708
Alkaptonuria (AKU) is a disease caused by a deficient homogentisate 1,2-dioxygenase activity leading to systemic accumulation of homogentisic acid (HGA), that forms a melanin-like polymer that progressively deposits onto connective tissues causing a pigmentation called “ochronosis” and tissue degeneration. The effects of AKU and ochronotic pigment on the biomechanical properties of articular cartilage need further investigation. To this aim, AKU cartilage was studied using thermal (thermogravimetry and differential scanning calorimetry) and rheological analysis. We found that AKU cartilage had a doubled mesopore radius compared to healthy cartilage. Since the mesoporous structure is the main responsible for maintaining a correct hydrostatic pressure and tissue homoeostasis, drastic changes of thermal and rheological parameters were found in AKU. In particular, AKU tissue lost its capability to enhance chondrocytes metabolism (decreased heat capacity) and hence the production of proteoglycans. A drastic increase in stiffness and decrease in dissipative and lubricant role ensued in AKU cartilage. Multiphoton and scanning electron microscopies revealed destruction of cell–matrix microstructure and disruption of the superficial layer. Such observations on AKU specimens were confirmed in HGA-treated healthy cartilage, indicating that HGA is the toxic responsible of morphological and mechanical alterations of cartilage in AKU. 相似文献
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3.
Agnese Brunzini Antonio Gracco Alida Mazzoli Marco Mandolini Steve Manieri Michele Germani 《Computer methods in biomechanics and biomedical engineering》2013,16(13):693-702
AbstractThe paper aims to evaluate the effects caused by a Mandibular Advancement Device (MAD) for Obstructive Sleep Apnoea Syndrome (OSAS) treatment. This study is based on Finite Element Method (FEM) for evaluating the load distribution on temporomandibular joint, especially on the mandibular condyle and disc, and on periodontal ligaments. The stress values on condyle and periodontal ligaments lead authors to consider MAD a safe procedure even for a long period. The obtained results also show the relationship between MAD material and load distribution at the periodontal ligaments. The paper is a step toward future analyses for studying and comparing the effects of MAD features, such as material, shape and dimensions, in order to allow the clinician prescribing the most fitting device. 相似文献
4.
Simone Fattorini Agnese Sciotti Patrizio Tratzi Andrea Di Giulio 《Journal of Zoological Systematics and Evolutionary Research》2013,51(4):279-286
The most pervasive macroecological patterns concern (1) the frequency distribution of range size, (2) the relationship between range size and species abundance and (3) the effect of body size on range size. We investigated these patterns at a regional scale using the tenebrionid beetles of Latium (Central Italy). For this, we calculated geographical range size (no. of 10‐km square cells), ecological tolerance (no. of phytoclimatic units) and abundance (no. of sampled individuals) using a large database containing 3561 georeferenced records for 84 native species. For each species, we also calculated body mass and its ‘phylogenetic diversity’ on the basis of cladistic relationships. Frequency distribution of range size followed a log‐normal distribution as found in many other animal groups. However, a log‐normal distribution accommodated well the frequency distribution of ecological tolerance, a so far unexplored issue. Range size was correlated with abundance and ecological tolerance, thus supporting the hypothesis that a positive correlation between distribution and abundance is a reflection of interspecific differences in ecological specialization. Larger species tended to have larger ranges and broader ecological tolerance. However, contrary to what known in most vertebrates, not only small‐sized, but also many medium‐to‐large‐sized species exhibited great variability in their range size, probably because tenebrionids are not so strictly influenced by body size constraints (e.g. home ranges) as vertebrates. Moreover, in contrast to other animals, tenebrionid body size does not influence species abundances, probably because these detritivorous animals are not strongly regulated by competition. Finally, contrary to the assumption that rare species should be mainly found among lineages that split from basal nodes, rarity of a tenebrionid species was not influenced by the phylogenetic position of its tribe. However, lineages that split from more basal nodes had lower variability in terms of species geographical distribution, ecological tolerance and abundance, which suggests that lineages that split from more basal nodes are not only morphologically conservative but also tend to have an ecological ‘inertia’. 相似文献
5.
Roberta Grande Domenico Corsi Raffaello Mancini Donatello Gemma Fabrizio Ciancola Isabella Sperduti Lorena Rossi Agnese Fabbri Maria G. Diodoro Enzo Ruggeri Germano Zampa Sara Bianchetti Teresa Gamucci 《PloS one》2013,8(12)
Background
Adjuvant chemotherapy (AC) in Stage II Colon Cancer (CC) is still under debate. Choice should be based on patients and disease characteristics. According to guidelines AC should be considered in high-risk T3N0 patients. No data are available for better option in low-risk patients. The aim of the study is to retrospectively evaluate relapse-free survival (RFS) and disease-free survival (DFS) according to treatment received in T3N0 CC.Methods
RFS and DFS are evaluated with Kaplan-Meier method. Multivariate Cox proportional hazard model was developed using stepwise regression, enter limit and remove limit were p = 0.10 and p = 0.15, respectively.Results
834 patients with T3N0 CC were recruited. Median age was 69 (29–93), M/F 463/371, 335 low-risk patients (40.2%), 387 high-risk (46.4%), 112 unknown (13.4%); 127 (15.2%) patients showed symptoms at diagnosis. Median sampled lymph nodes were 15 (1–76); 353 (42.3%) patients were treated with AC. Median follow up was 5 years (range 3–24). The 5-years RFS was 78.4% and the 5-years DFS was 76.7%. At multivariate analysis symptoms, lymph nodes, and adjuvant chemotherapy were prognostic factors for RFS. AC is prognostic factor for all endpoints.In low-risk group 5-years RFS was 87.3% in treated patients and 74.7% in non-treated patients (p 0.03); in high-risk group was respectively 82.7% and 71.4% (p 0.005).Conclusions
Data confirmed the role of known prognostic factors and suggest the relevance of adjuvant chemotherapy also in low-risk stage II T3N0 CC patients. However, the highest risk in low-risk subgroup should be identified to be submitted to AC. 相似文献6.
Stefano Chiari Marco Bardiani Agnese Zauli Sönke Hardersen Franco Mason Laura Spada Alessandro Campanaro 《Journal of Insect Conservation》2013,17(6):1255-1265
Quantitative information on population size, structure and dynamics are urgently needed for assessing species extinction risk and developing monitoring measures, especially for beetles belonging to the threatened guild of saproxylic organisms. Here freshly cut log piles (FCLP) were tested for the monitoring of the longhorn beetle Morimus asper (Sulzer, 1776) (Coleoptera: Cerambycidae). Novel mathematical models based on presence–absence or count data were compared with the most commonly used capture–recapture methods to investigate if less invasive and easier approaches may be suitable for large-scale monitoring of this species and other large saproxylic beetles. The use of FCLP as bait was reliable to detect the presence and abundance of M. asper, and capture events were not influenced by the phenomena of trap-happiness or trap-shyness. In order to obtain accurate presence–absence estimates of M. asper at a reasonable cost piles of at least 0.25 m3 are suggested. Models which take into account the abundance of the species without marking individuals were the best compromise between costs and accuracy of estimation. Therefore, a reliable assessment of the population size of M. asper, can be based on count data without marking individuals. Because FCLP attract adults of M. asper and other saproxylic beetles, they could act also as potential ecological traps if chipped and/or removed after the sampling season. Therefore, if FCLP are used in monitoring as a part of conservation programmes, the piles should be left until completely decayed. 相似文献
7.
Valentina Gambino Giulia De Michele Oriella Venezia Pierluigi Migliaccio Valentina Dall'Olio Loris Bernard Simone Paolo Minardi Maria Agnese Della Fazia Daniela Bartoli Giuseppe Servillo Myriam Alcalay Lucilla Luzi Marco Giorgio Heidi Scrable Pier Giuseppe Pelicci Enrica Migliaccio 《Aging cell》2013,12(3):435-445
8.
Bella S. Galil Ferdinando Boero Marnie L. Campbell James T. Carlton Elizabeth Cook Simonetta Fraschetti Stephan Gollasch Chad L. Hewitt Anders Jelmert Enrique Macpherson Agnese Marchini Cynthia McKenzie Dan Minchin Anna Occhipinti-Ambrogi Henn Ojaveer Sergej Olenin Stefano Piraino Gregory M. Ruiz 《Biological invasions》2015,17(4):973-976
9.
Francesca Ghirga Federica Aiello Sara Toscano Cinzia Ingallina Mariangela Siler Danilo Cucchi Agnese Po Evelina Miele Davide D'Amico Gianluca Canettieri Enrico De Smaele Elisabetta Ferretti Isabella Screpanti Gloria Uccello Barretta Maurizio Botta Bruno Botta Alberto Gulino Lucia Di Marcotullio 《The EMBO journal》2015,34(2):200-217
10.
Agnese Mancini Jesse Senko Ricardo Borquez-Reyes Juan Guzman Póo Jeffrey A. Seminoff Volker Koch 《Human ecology: an interdisciplinary journal》2011,39(6):743-756
Despite complete legal protection, improvements in infrastructure, and market conditions that provide easier access to other
protein sources, illegal poaching of sea turtles for consumption in Baja California Sur (BCS), Mexico remains a major threat
to their recovery. Few studies have focused on understanding the economic and social drivers behind this activity, which is
fundamental to determining best practices for discouraging it. From June 2007 to April 2008 we conducted eight in-depth, semi-structured
interviews with sea turtle poachers at five coastal communities in BCS to determine the drivers influencing them. The most
prevalent reasons for illegal poaching were direct economic benefits, lack of law enforcement and ease of escape from or bribery
of authorities, and strong family tradition. Our results suggest that to reduce illegal poaching it will be necessary to better
enforce existing environmental laws, reduce social acceptance of sea turtle hunting throughout the region, educate fishers
on the ecological importance of sea turtles, and show fishers direct economic benefits from non-consumptive use of sea turtles,
such as ecotourism. 相似文献