掌褶纹遗传的家系调查

近年来,国外学者作了一些掌褶纹的研究 工作〔61,我国也作了一些民族〔1,和某些疾病〔2,31 的各型掌褶纹频率的研究。为了对人类掌褶纹 有较深人的了解,并对临床医学工作有所帮助, 本文初步探讨了人类掌褶纹的遗传问题。     

掌褶纹遗传的家系调查

近年来，国外学者作了一些掌褶纹的研究 工作〔61，我国也作了一些民族〔1，和某些疾病〔2,31 的各型掌褶纹频率的研究。为了对人类掌褶纹 有较深人的了解，并对临床医学工作有所帮助， 本文初步探讨了人类掌褶纹的遗传问题。     

汉族ABO血型的皮纹特征分析

作者对芜湖地区３８２例（男２２０人;女１６２人）汉族ＡＢＯ血型的皮纹特征进行了分析,其中Ｏ型１３０人,Ａ型１１３人,Ｂ型１０１人,ＡＢ型３８人。分析比较了指纹类型、指纹组合格局、指嵴纹计数、掌嵴纹计数、ａｔｄ角,掌部真实花纹,掌褶纹和拇趾球纹等项参数,结果表明,ＡＢＯ各血型的皮纹参数间有若干统计学差异。     

长期高氟环境对肤纹的影响

本文对 32 2例高氟区人群的肤纹进行了分析 ,并与正常对照组及缺碘区人群作了比较。结果表明 :高氟区人群的肤纹参数与正常对照组有明显的差异 ,其中尺箕纹 (Lu)、变异型掌褶等项参数高于对照组 (P<0 0 1 ) ;而斗型纹 (W )、TFRC、TH I1 、I4区真实花纹出现率低于对照组 (P <0 0 1 )。高氟区人群的Lr 出现率、TFRC、变异型掌褶及掌部真实花纹出现率等指标与缺碘区人群基本相似。作者认为 ,长期高氟环境可能对居地人群遗传性状产生影响 ,肤纹出现的差异是其表达形式 ,同一地区人群遗传性状的差异可能与外环境微量元素的摄入水平有一定关系。     

内蒙地区蒙古,汉,回,朝鲜族指纹白线分析

本文分析了内蒙地区３５９７例蒙古、汉、回、朝鲜族人指纹白线分布特征,并探讨了指纹白线与皱纹掌和某些掌褶纹类型的关系。结果表明４个民族的指纹白线出现率：蒙古族１２．５７％、汉族１５．１７％、回族１８．８０％、朝鲜族１４．７８％。各民族的指纹白线出现率具有性别间和手别间明显差异,亦具民族间显著差异。此外,在这４个民族中,具指纹白线者的皱纹掌和桥贯型、悉尼型掌褶纹的相对出现率均较高。     

湖南侗族的手纹研究

报道了湖南通道侗族337例正常人的指纹型、总指纹嵴数（TFRC）、a-b纹嵴线（a-bRC)、atd角、轴三角百分距（tPD)、大鱼际纹、小鱼际纹、指间区纹、掌褶纹、掌纹主线横向指数（MLIT）等手纹参数正常值,并与侗族不同人群和湖南周边不同民族进行了比较,发现湖南侗族手掌真实花纹和掌褶纹分布频率与湖南周边其他已研究过的民族和侗族群体存在明显差异。     

白血病患者的肤纹研究

本文分析了l70名经骨髓检查确诊的白血病患者肤纹形态的手纹部分,数据经电子计算机进行判别分析,指纹类型的判对率为52.58±2.67％。根据掌褶类型判别时,其判对率为57±3.8％。指纹类型在判别急非淋患者及正常人时有显著性。掌褶类型的判别力对急非淋及慢粒患者有显著性。慢粒患者猿线出现率高于正常组。急淋患者右手悉尼线出现率高于正常组。此悉尼线在判别分析中有显著意义。急性白血病患者的弓斗指数高于对照组。白血病患者组掌纹白线的出现率也高于正常组。     

我国优秀散打运动员与几种疾病患者的手纹比较研究

通过对我国优秀散打运动员的手纹与几种疾病患者的手纹研究结果进行比对。发现我国优秀散打运动员手纹和胃癌、肺癌、食管癌患者的手纹特征相似,其斗型纹(W)增加和尺箕(Lu)减少的发展趋势一致。用统计学方法对相关指标数据分析,均与参照组、对照组具有显著性差异。建议优秀散打运动员合理饮食,重视预防以上恶性病变的发生。     

指纹与年龄相关性的量化分析

本文利用Leica M125体视显微镜对1510份样本中右手拇指的皱纹、乳突纹线密度、乳突纹线和小犁沟的宽度、细点线、屈肌褶纹等特征进行测量,通过SPSS软件分析年龄信息特征的相关性,选取其中相关性大的变量进行多元线性回归,并得出推断公式以分析并量化随年龄的增长指纹与年龄相关信息的变化特点及规律。研究结果显示,手印中的皱纹、乳突纹线密度、乳突纹线和小犁沟的宽度、细点线、屈肌褶纹等特征与年龄具有相关性,但利用这些变量构建的多元回归模型拟合优度并不高;皱纹、乳突纹线密度、乳突纹线和小犁沟的宽度、细点线、屈肌褶纹等可作为手印分析年龄的参考和辅助特征。乳突纹线的边缘形态、手印印痕的模糊程度、汗孔等以当前科技手段难以用测量描述特征的年龄信息,在手印分析年龄中或可发挥核心价值,具体还需进一步探究。     

安徽亳州地区回族的皮纹研究

本文报告了安徽省亳州地区400例 (男女各200人) 回族健康人的皮纹参数正常值。调查分析了指纹类型、指嵴纹计数、掌嵴纹计数、主线止区、atd角、t距比、掌褶和掌部花纹类型等项参数。比较了不同性别、左右侧、不同民族和人种间的差异。结果表明,回族有自己的手纹特点,又显示蒙古人种的一般特征。     

土著发酵床对商品猪生产性能和血液生化指标的影响

目的采集徐州当地土著微生物作为原始菌株制作发酵床,考察土著发酵床对商品猪生产性能及血液生化指标的影响。方法选择60头杜×长×大三元配套系仔猪进行实验,仔猪断奶日龄为21 d。实验组商品猪饲喂于发酵床猪舍,对照组饲喂于水泥地面猪舍。每组设3个重复,每个重复随机选取健康仔猪10头。仔猪饲喂125 d后考察土著发酵床对商品猪生产性能和血液生化指标的影响。结果土著发酵床具有一定提高商品猪日增重的效果,并可显著降低料重比（P〈0.05）,但对猪酮体品质未产生显著影响。在血液生化指标方面,实验组商品猪血液中的总蛋白、白蛋白、碱性磷酸酶含量均显著高于对照组（P〈0.05）。结论土著发酵床可以提高猪的生长性能和免疫机能。     

原发性自身免疫性肝硬化的超声图征象及肝脏弹性的分析

摘要 目的：探讨与分析原发性自身免疫性肝硬化的超声图征象及肝脏弹性特征。方法：研究时间为2017年2月至2019年12月,选择原发性自身免疫性肝硬化86例作为病例组,同期选择正常志愿者86例作为对照组,所有入选者都给予常规超声与弹性成像,记录成像特征并判断相关性。结果：病例组的全血谷草转氨酶(aspartate aminotransferase,AST)、谷丙转氨酶(alanine transarninase,ALT)、直接胆红素(direct bilirubin,DBIL)、总胆红素(total bilirubin,TBIL)与碱性磷酸酶(Alkaline phosphatase,ALP值都显著高于对照组(P<0.05)。病例组的肝脏回声、边界、内回声、血流等超声特征与对照组对比差异都有统计学意义(P<0.05)。病例组肝脏组织剪切波速度(shear wave velocity,SWV)、肝硬度高于对照组,应变率比值(Strain rate, SR)值低于对照组,对比差异都有统计学意义(P<0.05)。病例组的肝脏弹性硬度分级与对照组对比差异有统计学意义(P<0.05)。在病例组中,Pearson分析显示肝脏弹性硬度分级与肝脏回声、边界、内回声、血流等存在相关性(P<0.05)。结论：常规超声及肝脏弹性可反映原发性自身免疫性肝硬化的临床特征,两者存在相关性,可提高该病的鉴别诊断水平。     

血管内超声评价川崎病晚期患儿颈动脉功能、颈动脉内膜-中膜厚度和组织特征的临床研究

摘要 目的：探究血管内超声评价川崎病晚期患儿颈动脉功能、颈动脉内膜-中膜厚度和组织特征的临床价值。方法：选取81例川崎病晚期患儿作为本研究的川崎病组,同时选择同一时期的81例健康体检者作为本研究的对照组。所有受试者均通过血管内超声检查,对比分析两组一般临床资料、颈动脉功能、颈动脉内膜-中膜厚度、组织特征、颈动脉血流动力学和血管内皮功能。结果：川崎病组和对照组儿童的一般临床资料比较,差异均无统计学意义（P>0.05）。川崎病组患儿颈动脉血管僵硬度、脉搏波传导速度、颈动脉内膜-中膜厚度、血管的压力-应变弹性系数、硬度指数、颈动脉阻力指数和颈动脉僵硬度均显著高于对照组,而血管顺应性、血管径向应变率、动脉最大剪切率、颈动脉最小剪切率、颈动脉搏动指数和血管内皮依赖性舒张功能则显著小于对照组（P<0.05）。结论：血管内超声可有效评价川崎病晚期患儿颈动脉功能、颈动脉内膜-中膜厚度和组织特征,能够为后续疾病的治疗及预后提供重要参考,值得推广使用。     

Demand Characteristics of the Research Setting Can Influence Indexes of Negative Affect-Induced Eating in Obese Individuals

Measures of negative affect-induced eating (NAIE) are common in clinical research with obese individuals. However, previous studies suggest that measures of NAIE can be induced by social desirability tendencies or demand characteristics of the research setting. Using an experimental design, the present study tested the effects of demand characteristics of the research setting on selfreport and behavioral indexes of NAIE. Obese and nonobese subjects (n=107) were randomly assigned to an experimental or control group. Experimental subjects received a lecture indicating an association between emotional eating and obesity; control subjects received no information. Outcome measures were indexes of NAIE from a questionnaire, food diaries, and food intake during a laboratory “taste test.” We hypothesized that the association between relative body mass and NAIE would be stronger among subjects receiving the lecture manipulation than control subjects. Results indicated that NAIE indexes, particularly from food diaries, were influenced modestly by research demand characteristics. We conclude that demand characteristics of the research setting can affect indexes of NAIE among obese persons.     

Neuropsychological Characteristics of Cortical and Subcortical Zones of the Human Brain as Multidimensional Genetic Risk Factors of Schizophrenia

A neuropsychological study of 59 families with schizophrenia (193 subjects: 59 patients, 109 parents, and 25 sibs) was conducted using the methods of A.R. Luria. The control group included 23 healthy subjects without a familial history of schizophrenia. The analysis revealed a wide spectrum of mental disorders in schizophrenics and their relatives but not in the control group. The disorders varied from vague to distinct. The most informative for discrimination of the subject groups were interrelated integrative characteristics of the left and right subcortical, left subcortico-frontal, and left subcortico-temporal areas. The errors of discrimination between schizophrenics and control subjects (a low-risk group) and between the low-risk group and sibs (a high-risk group) ranged from 7 to 19%. The multidimensional neuropsychological indicators revealed may be used for further analysis of genetic risks of schizophrenia.     

HFJ和Wistar大鼠脂肪肝及胰岛素抵抗动物模型的比较

目的建立近交系HFJ大鼠和封闭群Wistar大鼠脂肪肝胰岛素抵抗动物模型及比较其生物学特性。方法雄性HFJ大鼠和Wistar大鼠,分别随机分为模型组和正常组,模型组喂养高脂饮食,正常组喂养普通饮食,两组脂肪分别占摄入能量的44.2%和19.2%,共饲养12周。每周称体质量,测定血糖、甘油三酯、胆固醇、ALT、AST、HDLC、LDLC和血胰岛素水平。实验期末处死动物摘取肝脏并称质量,计算肝指数;鼠肝脏用10%甲醛固定,石蜡包埋切片,HE染色,光镜下评估肝脂肪变性和炎症活动情况。结果镜下可见,HFJ和Wistar大鼠模型组肝细胞均呈现弥漫性脂肪变性,小叶内可见炎症细胞浸润,HFJ比Wistar脂肪变性较重,对照组肝脏均未见异常。两种动物的模型组ALT、AST、肝指数、HOMA-IR指数均显著高于其正常组,HFJ和Wistar种系间各指标的差异无显著性;HFJ大鼠模型组体重和正常组体重具有显著性差异(P<0.01),而Wistar大鼠模型组体重与正常组体重间无显著差异(P>0.05);HFJ大鼠TG和TC含量均显著高于Wistar大鼠。结论通过高脂饮食喂养成功建立了HFJ大鼠和Wistar大鼠脂肪肝与胰岛素抵抗疾病动物模型,与Wistar大鼠比较,HFJ大鼠具有自发性高血脂特征,造模更易成功,可为胰岛素抵抗和脂肪肝的发病机制研究、防治高血脂药物筛选提供一种新的实验动物。     

广泛性焦虑障碍患者人格特征与免疫功能、甲状腺激素和神经内分泌激素的相关性分析

摘要 目的：探讨广泛性焦虑障碍（GAD）患者人格特征与免疫功能、甲状腺激素和神经内分泌激素的相关性。方法：选择2019年1月~2020年12月北部战区空军医院心理科收治的GAD患者80例作为研究组,选择同期于北部战区空军医院体检的健康志愿者80例作为对照组。应用艾森克人格问卷简式量表中国版（EPQ-RSC）对受试者人格特征进行评价,比较两组EPQ-RSC评分结果、血液中CD3⁺、CD4⁺、自然杀伤细胞（NK）比例,血清白细胞介素（IL）-2、IL-6,三碘甲状腺原氨酸（T3）、甲状腺素（T4）、游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）、促甲状腺激素（TSH）、去甲肾上腺素（NE）、促肾上腺皮质激素（ACTH）、皮质醇（CS）水平,并分析其相关性。结果：研究组精神质（P）、神经质（N）评分及EPQ-RSC总分均显著高于对照组（P<0.05）,研究组CD3⁺、CD4⁺、NK比例显著低于对照组,血清IL-2、IL-6水平显著高于对照组（P<0.05）。研究组血清FT3、FT4水平显著低于对照组（P<0.05）。研究组血清CS水平显著低于对照组,NE、ACTH水平显著高于对照组（P<0.05）。Pearson相关分析显示,GAD患者N、P评分及EPQ-RSC总分与CD3⁺、CD4⁺、NK、FT3、FT4、CS呈负相关（P<0.05）,与IL-2、IL-6、NE、ACTH呈正相关（P<0.05）。结论：GAD患者存在免疫功能损伤、神经内分泌激素和甲状腺激素水平异常,且均与患者P、N倾向的人格特征有关。     

The Influence of Voice Volume, Pitch, and Speech Rate on Progressive Relaxation Training: Application of Methods from Speech Pathology and Audiology

Vocal characteristics of therapists, including voice volume, pitch and timbre of speech, and rate of speech have been hypothesized to facilitate the therapeutic process, particularly during procedures like progressive relaxation training (PRT). Very little empirical work, however, has examined the relation between vocal characteristics and treatment process or outcome. The purpose of this study was to examine the role of vocal characteristics during a single session of PRT applying technological innovations devised for speech pathology and audiology settings for evaluating therapist's vocal characteristics. Forty-eight high anxious young adult women were randomly assigned to one of four conditions for training: PRT with the recommended therapist voice (RV) that decreased in tone, volume, and rate across the session, PRT with conversational therapist voice during the session (CV), a credible treatment control called systematic self-relaxation (SR), or no treatment control (NT). All subjects participated in a single PRT session during which heart rate, EMG, self-report measures of tension (SRT) and anxiety, and treatment credibility ratings were obtained. Results revealed significant reductions in SRT, self-reported anxiety, and heart rate for participants in all groups. Only the RV group displayed significant reductions in EMG when compared with the other three groups. Participants in the RV group also rated the therapist's voice as “more facilitating” of relaxation when compared to the CV group. These results suggest that methods employed for evaluating the quality of vocal characteristics in speech and audiology clinics may be useful for evaluating the quality of therapist's voice when conducting PRT.     

Quantitative and statistical analysis of the shape of amperometric spikes recorded from two populations of cells

Previously used methods of comparing amperometric spike characteristics from two separate groups of cells have entailed pooling all the values for a spike characteristic from each group of cells and then statistically comparing the two samples. Although this approach has indicated that there are significant differences between the spike characteristics from coloboma and control mouse chromaffin cells, the results are not consistent between experiments. We have reexamined the assumptions of the statistical tests used as well as the variability inherent in amperometric data measured from two groups of cells. Our findings indicate that when comparing amperometric spike characteristics between groups of cells, it is more appropriate to compare samples of mean spike values. This method consistently indicates that there is no difference between coloboma and control amperometric spikes. These results have been validated by using samples of mean spike characteristics to detect changes in the shape of amperometric spikes from both mouse chromaffin cells at 37 degrees C and PC12 cells previously exposed to 50 microM L-3,4-dihydroxyphenylalanine and by the use of an additional analysis method, the nested ANOVA. Together, these results indicate that pooled samples of amperometric spike characteristics can give results that may confound the interpretation of amperometric data.     

Tunable Slow Light in Graphene Metamaterial in a Broad Terahertz Range

A graphene-based metamaterial with tunable electromagnetically induced transparency is numerically studied in this paper. The proposed structure consists of a graphene layer composed of H shape between two cut wires, by breaking symmetry can control EIT-like effects and by increasing the asymmetry in the structure has strong coupling between elements. It is important that the peak frequency of transmission window can be dynamically controlled over a broad frequency range by varying the chemical potential of graphene layer. The results show that high refractive index sensitivity and figure of merit can be achieved in asymmetrical structures which is good for sensing applications. We calculated the group delay and the results show we can control the group velocity by varying the S parameter in asymmetrical structure. The characteristics of our system indicate important potential applications in integrated optical circuits such as optical storage, ultrafast plasmonic switches, high performance filters, and slow-light devices.