机械通气救治4例银环蛇咬伤急性呼吸衰竭

目的 探讨机械通气救治银环蛇咬伤致急性呼吸衰竭的治疗效果。方法 院前正确清创急救处理,及时行机械通气救治4例银环蛇咬伤致急性呼吸衰竭患者。结果 气管内插管是最佳的气道开放方法,气管插管者辅助通气4～6h后撤机及拔管可获得成功。结论 正确急救和清创,气管内插管及机械通气是救治银环蛇咬伤致急性呼吸衰竭的最有效的方法。     

银环蛇咬伤致急性呼吸衰竭的治疗及临床观察

目的观察抗银环蛇毒血清和机械通气对银环蛇咬伤致急性呼吸衰竭的疗效。方法应用抗蛇毒血清和机械通气救治23例银环蛇咬伤致急性呼吸衰竭患者。结果银环蛇咬伤患者及早应用抗银环蛇毒血清,毒蛇咬伤后发生急性呼吸衰竭时间为2.5～16h。当患者出现睁眼困难、吞咽困难、呼吸节律改变或呼吸困难时,即予气管插管行机械通气,可获得较好的疗效。结论机械通气辅助抗蛇毒血清是救治银环蛇咬伤致呼吸衰竭有效的方法。     

中西医结合救治毒蛇咬伤致急性呼吸衰竭的临床观察

目的 探讨中西医结合救治毒蛇咬伤致急性呼吸衰竭的治疗效果.方法 应用中西医结合的方法(机械通气、抗蛇毒血清结合中医中药)救治46例毒蛇咬伤致急性呼吸衰竭患者.结果 46例全部痊愈出院.结论 中西医结合治疗措施是救治毒蛇咬伤致急性呼吸衰竭的最有效方法.     

机械通气辅助抗蛇毒血清抢救银环蛇咬伤致呼吸衰竭的临床分析

目的观察抗蛇毒血清和机械通气对银环蛇咬伤致呼吸衰竭的疗效。方法应用机械通气和抗蛇毒血清救治16例银环蛇咬伤致呼吸衰竭患者。结果16例病人全部救活。患者出现眼睑下垂,呼吸节律改变或呼吸困难时,及早予经鼻气管插管行机械通气和应用抗蛇毒血清,能有效地抢救蛇伤致呼吸衰竭患者生命。结论机械通气辅助抗蛇毒血清是救治银环蛇咬伤致呼吸衰竭的有效方法。     

毒蛇咬伤致急性呼吸衰竭38例救治分析

目的探讨毒蛇咬伤致急性呼吸衰竭的发病机制和治疗措施。方法选择毒蛇咬伤患者38例,应用抗蛇毒血清、机械通气等综合治疗。结果经综合救治措施治疗,38例全部痊愈出院。结论综合救治措施是抢救毒蛇咬伤致急性呼吸衰竭最有效的方法。     

毒蛇咬伤致急性呼吸肌麻痹16例急救护理体会

蛇伤导致呼吸肌麻痹常在咬伤后数小时至数天内发生,是蛇伤病人最常见的危重症状。我科2010年1月～2012年1月共收治16例毒蛇咬伤致急性呼吸肌麻痹患者。经采取紧急气管插管辅予机械通气辅助呼吸以及对症治疗和有效的护理措施,取得满意效果。现将体会报告如下。     

80例神经毒类毒蛇咬伤的流行病学特点及急诊救治

目的总结分析80例神经毒类毒蛇咬伤的流行病学特点及急诊救治经验。方法收集80例神经毒类毒蛇咬伤的临床资料,分析其临床特点并总结救治经验和体会。结果 80例神经毒类毒蛇咬伤抢救成功率100%,痊愈率100%,总有效率100%。结论综合治疗神经毒类毒蛇咬伤的疗效显著。早期使用氧疗和机械辅助呼吸以及抗蛇毒血清等治疗方法是神经毒类毒蛇咬伤呼吸衰竭抢救成功的关键。     

毒蛇咬伤致重症肌无力样综合征1例报告

毒蛇咬伤致重症肌无力样综合征,主要为神经毒类毒蛇咬伤后引起全身骨骼肌麻痹,包括呼吸肌麻痹,如果抢救不及时,患者多因呼吸衰竭而死亡。我科成功救治1例毒蛇咬伤致重症肌无力样综合征患者,现报告如下。     

急救护理路径在银环蛇咬伤重症患者急救护理中的应用

目的探讨急救护理路径在银环蛇咬伤患者急救护理中的应用效果。方法选取我院2017年1月～2019年11月收治的银环蛇咬伤患者60例,按随机表法分为对照组和研究组。对照组给予毒蛇咬伤常规护理干预,研究组给予急救护理路径,观察比较两组患者入院处置时间、机械通气时间与住院时间,并对预见性气管插管、紧急气管插管、肺部感染与意外拔管等指标进行比较。结果两组患者经不同急诊护理干预后,研究组患者在入院处置时间、机械通气时间与住院时间方面均显著优于对照组,差异有统计学意义(均P0.05);而且研究组患者在预见性气管插管、紧急气管插管、肺部感染与意外拔管等指标上均显著优于对照组(均P0.05)。结论急救护理路径应用于银环蛇咬伤患者急救护理中的效果显著,可缩短救治时间和住院时间,降低并发症发生率,促进患者康复,值得临床推广应用。     

5例毒蛇咬伤患者的急救与护理

毒虼咬伤的发病率以夏秋季节最高,常因延误就诊或处理不当而在短时间内出现蛇毒中毒致休克、急性呼吸衰竭、弥散性血管内凝血、急性心力衰竭、急性肾功能衰竭等危重症。因此．及时有效的护理措施是争取抢救时机．改善病情。促进救治成功的关键。我院2006年1月～2008年12月成功救治了s5例毒蛇咬伤的患者,现将急救与护理介绍如下。     

A Unique Protease Cleavage Site Predicted in the Spike Protein of the Novel Pneumonia Coronavirus (2019-nCoV) Potentially Related to Viral Transmissibility

正Dear Editor,In December 2019, a novel human coronavirus caused an epidemic of severe pneumonia(Coronavirus Disease 2019,COVID-19) in Wuhan, Hubei, China(Wu et al. 2020; Zhu et al. 2020). So far, this virus has spread to all areas of China and even to other countries. The epidemic has caused 67,102 confirmed infections with 1526 fatal cases     

Curcuminoids as inhibitors of thioredoxin reductase: A receptor based pharmacophore study with distance mapping of the active site

Curcumin is the yellow pigment of turmeric that interacts irreversibly forming an adduct with thioredoxin reductase (TrxR), an enzyme responsible for redox control of cell and defence against oxidative stress. Docking at both the active sites of TrxR was performed to compare the potency of three naturally occurring curcuminoids, namely curcumin, demethoxy curcumin and bis-demethoxy curcumin. Results show that active sites of TrxR occur at the junction of E and F chains. Volume and area of both cavities is predicted. It has been concluded by distance mapping of the most active conformations that Se atom of catalytic residue SeCYS498, is at a distance of 3.56 from C13 of demethoxy curcumin at the E chain active site, whereas C13 carbon atom forms adduct with Se atom of SeCys 498. We report that at least one methoxy group in curcuminoids is necessary for interation with catalytic residues of thioredoxin. Pharmacophore of both active sites of the TrxR receptor for curcumin and demethoxy curcumin molecules has been drawn and proposed for design and synthesis of most probable potent antiproliferative synthetic drugs.     

Comparative morphology of the carpel in the Liliaceae: Hewardieae, Petrosavieae, and Tricyrteae

The young pistils in the melanthioid tribes, Hewardieae, Petrosavieae and Tricyrteae, are uniformly tricarpellate and syncarpous. They lack raphide idioblasts. All are multiovulate, with bitegmic ovules. The Petrosavieae are marked by the presence of septal glands and incomplete syncarpy. Tepals and stamens adhere to the ovary in the Hewardieae and the Petrosavieae but not in the Tricyrteae. Two vascular bundles occur in the stamens of the Hewartlieae and Tricyrtis latifolia. Ventral bundles in the upper part of the ovary of the Hewardieae are continuous with compound septal bundles and placental bundles in the lower part. Putative ventral bundles occur in the alternate position in the Tricyrteae and putative placental bundles in the opposite. position in the Petrosavieae. The dichtomously branched stigma in each carpel of the Tricyrteae is supplied by a bifurcated dorsal bundle.     

Enterovirus 71 3C proteolytically processes the histone H3 N-terminal tail during infection

Highlights
1. The N-terminal tail of histone H3 is specifically cleaved during EV71 infection.
2. Viral protease 3C is identified as a protease responsible for proteolytically processing the N-terminal H3 tail.
3. Our finding reveals a new epigenetic regulatory mechanism for Enterovirus 71 in virus-host interactions.     

Detection of EBV and HHV6 in the Brain Tissue of Patients with Rasmussen’s Encephalitis

Rasmussen’s encephalitis (RE) is a rare pediatric neurological disorder, and the exact etiology is not clear. Viral infection may be involved in the pathogenesis of RE, but conflicting results have reported. In this study, we evaluated the expression of both Epstein-Barr virus (EBV) and human herpes virus (HHV) 6 antigens in brain sections from 30 patients with RE and 16 control individuals by immunohistochemistry. In the RE group, EBV and HHV6 antigens were detected in 56.7% (17/30) and 50% (15/30) of individuals, respectively. In contrast, no detectable EBV and HHV6 antigen expression was found in brain tissues of the control group. The co-expression of EBV and HHV6 was detected in 20.0% (6/30) of individuals. In particular, a 4-year-old boy had a typical clinical course, including a medical history of viral encephalitis, intractable epilepsy, and hemispheric atrophy. The co-expression of EBV and HHV6 was detected in neurons and astrocytes in the brain tissue, accompanied by a high frequency of CD8⁺ T cells. Our results suggest that EBV and HHV6 infection and the activation of CD8⁺ T cells are involved in the pathogenesis of RE.     

Perinatal Vertical Transmission of Chikungunya Virus in Ruili,a Town on the Border between China and Myanmar

正Dear Editor,Chikungunya virus (CHIKV), an arbovirus in the family of Togaviridae, genus Alphavirus, is transmitted by the A.aegyptii or A. albopictus mosquito, and causes disease in humans characterized by fever, rash, and arthralgia (Silva and Dermody 2017; Suhrbier 2019). It was first reported in 1953 in Tanzania, and caused only a few outbreaks and sporadic cases in Africa and Asia in last century. However, in the epidemic in 2004, CHIKV acquired mutations that conferred enhanced transmission by the A. albopictus mosquito(Schuffenecker et al. 2006). Since then, it has successively caused outbreaks in Africa, the Indian Ocean, South East Asia, the South America, and Europe (Zeller et al. 2016).     

Development of a Novel Reverse Transcription Loop-Mediated Isothermal Amplification Method for Rapid Detection of SARS-CoV-2

In conclusion, the novel visual RT-LAMP assay is a simple, rapid, and sensitive approach for detection of SARS-CoV-2, and it is ready for application in primary care and community hospitals or health care centers, and even patients' own houses in response to the current SARS-CoV-2 epidemic because the assay does not require sophisticated equipment and skilled personnel. Furthermore, it is also ready to be used in fields for screening samples from wild animals and environments to facilitate the identification of potential intermediate hosts that mediate the cross-species transmission of SARS-CoV-2 from bats to humans.