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卷柏属植物含有黄酮类、炔酚类、苯丙素类等多种化学成分。药理学研究证明该属植物具有抗肿瘤、抗炎、抗氧化、抗菌抗病毒等药理活性。本文系统地介绍了国内外对卷柏属植物化学成分和药理活性方面的研究概况,为今后对该属植物的进一步研究提供参考。 相似文献
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白藜芦醇生物学活性研究进展 总被引:1,自引:0,他引:1
白藜芦醇是一种植物抗毒素,主要存在于虎杖、葡萄及花生等有限的植物中,它具有对人体有益的生物学活性,如具有拮抗肿瘤作用、心血管保护作用、抗炎作用、抗病毒作用、神经保护作用、植物雌激素作用和对骨钙的影响等。 相似文献
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《天然产物研究与开发》2016,(6)
天然产物已被用来防治人类疾病数千年,并在药物发现和发展中发挥越来越大的作用。白桦脂酸(betulinic acid,BA)又称白桦酸、桦木酸,是一种五环三萜酸,存在于多种植物中。近年来的研究表明,BA具有多种多样的生物活性,如抗肿瘤、抗病毒、抗炎、抗菌、抗疟疾等,尤其是在抗肿瘤和抗HIV方面,特别是针对黑色素肿瘤细胞具有专一的杀死作用,因此得到了广泛关注。更重要的是BA衍生物抗HIVⅡ期临床实验已经取得成功,所以BA目前已被认为是最具潜力的药物先导化合物之一。因此,本综述从BA的制备合成以及药理活性等方面对近年来的相关研究进行概括总结,以期为BA的研究和开发利用提供参考。 相似文献
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植物内生菌及其活性代谢产物 总被引:18,自引:1,他引:17
植物内生茵是一种新的微生物资源,具有潜在的应用价值。近年来,从植物内生茵中寻找新的生物活性物质的研究方兴未艾。对近年来从植物内生茵中发现的抗肿瘤、抗茵、抗病毒、杀虫、免疫抑制、抗氧化、降糖等活性化合物及其相应的产生茵的研究作一简要综述。 相似文献
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Paulo Luísa Ferreira Susana Gallardo Eugenia Queiroz João António Domingues Fernanda 《World journal of microbiology & biotechnology》2010,26(8):1533-1538
Resveratrol (3,4′,5-trihydroxistilbene) is a phytoalexin commonly found in food and drinks, which is thought to possess antimicrobial
activity. These effects together with its well known antioxidant properties are beneficial for the prevention of some diseases,
e.g. cancer. In this study we have verified that resveratrol has antibacterial activity against all tested Gram-positive bacteria
using both the disk diffusion and broth microdilution methods. Time kill assays of this compound against Gram-positive bacteria
showed that its effects on the growth of bacterial cells were due to bacteriostatic action. The addition of resveratrol has
allowed the identification of changes in cell morphology and DNA contents, which have been assessed through microscopic analysis
and flow cytometry; this suggests that the cell cycle is affected by resveratrol. This study indicates that this compound
may have potential as a natural antibacterial agent for both food preservation and medicinal use. 相似文献
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Li Zhang Yuanyuan Li Zhiwen Gu Yuyue Wang Mei Shi Yun Ji Jing Sun Xiaopeng Xu Lirong Zhang Jingtin Jiang Weifeng Shi 《PloS one》2015,10(2)
Polydatin and resveratrol, as major active components in Polygonum cuspidatum, have anti-inflammatory, antioxidant and antitumor functions. However, the effect and mechanism of polydatin and resveratrol on enterovirus 71 (EV71) have not been reported. In this study, resveratrol revealed strong antiviral activity on EV71, while polydatin had weak effect. Neither polydatin nor resveratrol exhibited influence on viral attachment. Resveratrol could effectively inhibit the synthesis of EV71/VP1 and the phosphorylation of IKKα, IKKβ, IKKγ, IKBα, NF-κB p50 and NF-κB p65, respectively. Meanwhile, the remarkably increased secretion of IL-6 and TNF-α in EV71-infected rhabdosarcoma (RD) cells could be blocked by resveratrol. These results demonstrated that resveratrol inhibited EV71 replication and cytokine secretion in EV71-infected RD cells through blocking IKKs/NF-κB signaling pathway. Thus, resveratrol may have potent antiviral effect on EV71 infection. 相似文献
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白藜芦醇抑制嗜水气单胞菌毒力作用研究 总被引:1,自引:0,他引:1
为探索白藜芦醇(Resveratrol, Res)在水产动物细菌病防控中的应用价值, 实验以淡水养殖中重要的细菌病原嗜水气单胞菌(Aeromonas hydrophila)为研究对象, 通过设置药物浓度梯度, 检测其对嗜水气单胞菌生长、生物膜形成和溶血活性的抑制作用, 和对毒力及群感调控系统相关基因表达的影响; 同时通过人工感染异育银鲫(Carassius auratus gibelio)试验检测其对鱼体保护作用和对鱼体炎症相关因子基因表达的影响。结果显示: 白藜芦醇对嗜水气单胞菌的最小抑菌浓度(MIC)>1024 μg/mL; 浓度低于64 μg/mL时, 对菌株生长影响不显著; 浓度≥32 μg/mL时, 对病原菌株生物膜形成和溶血活性具有显著抑制作用(P<0.05), 且随剂量增加而增强。荧光定量RT-PCR结果分析发现白藜芦醇能引起嗜水气单胞菌群感调控系统中luxR和luxS基因分别显著上调和下调表达; 外膜蛋白基因omp表达显著下降。人工感染试验发现攻毒前两小时腹腔注射25、50和100 mg/kg白藜芦醇处理组的异育银鲫死亡率显著下降, 鱼体炎症相关的肿瘤坏死因子(TNF-α)和Ⅱ型干扰素(IFN-γ)的mRNA表达量也显著下降。研究表明药用植物大黄、虎杖等所含白藜芦醇成分能有效抑制嗜水气单胞菌毒力, 降低鱼体炎症反应的功效; 腹腔注射25—100 mg/kg白藜芦醇对感染病原菌的异育银鲫有一定保护作用。 相似文献
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The calculations based on the density functional theory (DFT) have been used to study the structure-activity of resveratrol in the chain reaction of autooxidation. According to the geometry obtained by using a B3LYP/6-31G**, the HOMO, LUMO of resveratrol and the spin density, the single electron distribution of the 4'- and 5-radical of resveratrol were calculated, it was found that resveratrol is a potential antioxidant. The 4'-hydroxyl group of resveratrol is more reactive than 3- and 5-positions because of the resonance effects. The dominant structure of the resveratrol radicals is a semiquinone structure which determines the stability of radicals, and the unpaired electron is mainly distributed to the O-atom and its ortho and para positions. The antioxidant activity of resveratrol is related to the spin density and the unpaired electron distribution of the O-atom. 相似文献
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Gui-Juan Fan Xiao-Da Liu Yi-Ping Qian Ya-Jing Shang Xiu-Zhuang Li Fang Dai Jian-Guo Fang Xiao-Ling Jin Bo Zhou 《Bioorganic & medicinal chemistry》2009,17(6):2360-2365
Resveratrol (3,5,4′-trans-trihydroxystibene) is a natural phytoalexin present in grapes and red wine, which possesses a variety of biological activities including antioxidant activity. In order to find more active antioxidant with resveratrol as the lead compound we synthesized 4,4′-dihydroxy-trans-stilbene (4,4′-DHS). The antioxidant activities of resveratrol and 4,4′-DHS were evaluated by the reaction kinetics with galvinoxyl radical or Cu(II) ions, and the inhibition effects against free-radical-induced peroxidation of human erythrocyte ghosts. It was found that 4,4′-DHS exhibits remarkably higher antioxidant activity than resveratrol. The oxidative products of resveratrol and 4,4′-DHS in the presence of Cu(II) in acetonitrile were identified as the dihydrofuran dimers by spectroscopic method, and the antioxidant mechanism for 4,4′-DHS was proposed. In addition, 4,4′-DHS exhibits remarkably higher cytotoxicity against human promyelocytic leukemia (HL-60) cells than resveratrol. 相似文献
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We have studied the effect of resveratrol on lipoperoxidation and antioxidant enzyme activity level in the brain of healthy
rats. When intraperitoneally administered, resveratrol significantly and dose dependently decreased brain malondialdehyde
level. Resveratrol also increased in a dose-dependent way brain superoxide dismutase, catalase and peroxidase activities.
Optimal effect on antioxidant enzyme and lipoperoxidation products were obtained with resveratrol concentration of 12.5 mg/kg
body wt. Native polyacrylamide gel electrophoresis analysis of antioxidant isoenzymes revealed that resveratrol up regulated
at least two acidic superoxide dismutase isoforms called A1 and A2, two basic isoforms called B1 and B2. Resveratrol also up regulated two catalase isoforms and a broad peroxidase band corresponding to several isoforms. All these
findings suggest that resveratrol is able to cross the blood brain barrier and exerts potent antioxidant features. Resveratrol
also exerts neuroprotective properties by up regulating several detoxifying enzymes, most of which are iron proteins. 相似文献
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本文利用甲醇溶剂对酿酒葡萄皮渣进行浸提,得到白藜芦醇粗提物.粗提物通过硅胶柱层析进行纯化.然后,研究了白藜芦醇的氧自由基、超氧阴离子自由基、羟自由基、DPPH自由基的清除能力.结果显示:白藜芦醇具有很强的自由基清除能力和抗氧化能力,并且随着浓度的增加,抗氧化能力增强. 相似文献
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Hichem Sebai Mamane Sani Ezzedine Aouani Néziha Ghanem-Boughanmi 《Free radical research》2013,47(11-12):913-920
Lipopolysaccharide (LPS) is a glycolipid component of the cell wall of gram negative bacteria inducing deleterious effects on the kidney. Endotoxemia-induced nephrotoxicity is characterized by disturbed intracellular redox balance and reactive oxygen species (ROS) accumulation leading to DNA, proteins and membrane lipid damages. Resveratrol (trans-3,5,4′-trihydroxystilbene) is a polyphenol displaying antioxidant and anti-inflammatory properties. This study investigated its effects on LPS-induced nephrotoxicity in rats. Resveratrol counteracted all LPS-induced changes in renal haemodynamic parameters. In the kidney resveratrol abrogated LPS-induced lipoperoxidation and antioxidant enzyme activities depletion as superoxide dismutase (SOD) and catalase (CAT) but not peroxidase (POD) activity. LPS increased plasma and urine nitric oxide (NO) level and resveratrol reversed them. More importantly, LPS-induced iron mobilization from plasma to kidney, which was also abolished by resveratrol treatment. All these results suggest that resveratrol exerted strong antioxidant properties against LPS-induced nephrotoxicity and that its mode of action seemed to involve iron shuttling proteins. 相似文献
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本文综述了海草中生物活性成分的研究进展,其化学成分类型主要是苯酚类、黄酮类和二萜类化合物,生物活性主要包括抗菌、抗氧化、抗病毒、细胞毒性、抑制海藻生长和抗污损等. 相似文献
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《Phytomedicine》2020
BackgroundRotavirus (RV) is the primary causative agent for viral gastroenteritis among infants and young children worldwide. Currently, no clinically approved and effective antiviral drug for the treatment of RV infection is available.PurposeWe investigated the potential anti-RV activity of resveratrol and underlying mechanisms by which resveratrol acted against RV.MethodsThe anti-RV activity of resveratrol in vitro was evaluated using plaque reduction assays. The effects of resveratrol on yield of virion progeny, viral polyprotein expression and genomic RNA synthesis were respectively investigated using enzyme-linked immunosorbent assays, western blotting and qRT-PCR assays. Further, we also measured the antiviral effect of resveratrol by evaluation of antigen clearance and assessment of changes in proinflammatory cytokines/chemokines in RV-infected neonatal mouse model.ResultsOur results indicated that 20 μM of resveratrol significantly inhibited RV replication in Caco-2 cell line by suppressing RV RNA synthesis, protein expression, viroplasm plaque formation, progeny virion production, and RV-induced cytopathy independent of the different strains and cell lines of RV that we used. Analysis of the effect of time post-addition of resveratrol indicated that its application inhibited early processes in the RV replication cycle. Further study of the underlying mechanism of anti-RV activity indicated that resveratrol inhibited RV replication by suppressing expression of heat-shock protein 90 (HSP90) mRNA and protein, and that the effect occurred in a dose-dependent manner. Overexpression of HSP90 was found to have attenuated the inhibitory effect of resveratrol on RV replication. Interestingly, the application of resveratrol were found to down-regulate the level of inhibition of RV-mediated MEK1/2 and ERK phosphorylation. Using a RV-infected suckling mice model, we found that application of resveratrol significantly lessened the severity of diarrhea, decreased viral titers, and relieved associated symptoms. Levels of mRNA expression of interleukin-2, interleukin-10, tumor necrosis factor-α, interferon-γ, macrophage inflammatory protein 1, and monocyte chemotactic protein-1 were all found to have been sharply reduced in intestinal tissue from mice which had been treated with resveratrol (10 or 20 mg/kg) after RV infection (p < 0.05).ConclusionThese findings implied that resveratrol exhibits antiviral activity and could be a promising treatment for rotavirus infection. 相似文献