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1.
中国拟小鲵属(有尾目,小鲵科)一新种记述   总被引:6,自引:0,他引:6  
在比较和研究拟小鲵属已知物种黄斑拟小鲵、水城拟小鲵后,确定贵州省绥阳县宽阔水所产拟小鲵为1新种,即宽阔水拟小鲵Pseudohynobius kuankuoshuiensis.新种与黄斑拟小鲵近似,但新种体尾背面黄斑近圆形,头长与头宽之比大于1.55,可与之区分.新种与水城拟小鲵P.shuichengensis相似,但新种体尾及四肢背面有黄色斑块,四肢贴体相向时掌、踱部前半不重叠,而极易与之相区别.  相似文献   

2.
拟小鲵属(有尾目:小鲵科)一新种--水城拟小鲵   总被引:5,自引:0,他引:5  
田应洲  李松  谷晓明 《动物学报》2006,52(3):522-527
在比较和研究拟小鲵属(Pseudohynobius)已知二物种后,确定贵州省水城县石龙乡产拟小鲵为一新种,即水城拟小鲵(PseudohynobiusshuichengensisTian,LietGusp.nov)。新种与黄斑拟小鲵(P.flavomaculatus)的犁骨齿列形状相似;但新种体尾及四肢背面紫褐色,无黄色斑块;四肢长,前后肢贴体相向时,掌、部前半重叠;而黄斑拟小鲵体尾及四肢背面紫褐色,有土黄色斑块;四肢甚短,前后肢贴体相向时,指、趾仅相遇或略重叠。秦巴拟小鲵(P.tsinpaensis)背面棕褐色,体尾及四肢背面有不规则云状斑;四肢较短,前后肢贴体相向时,指、趾末端仅相遇。本文统计并记述了新种的外形、头骨特征、生物学资料。  相似文献   

3.
湘中西部小鲵属一新种--挂榜山小鲵(两栖纲:小鲵科)   总被引:15,自引:0,他引:15  
沈猷慧  邓学建  王斌 《动物学报》2004,50(2):209-215
在比较和研究小鲵属Hynobius物种后 ,确定湖南省祁阳县产小鲵为一新种 ,即挂榜山小鲵Hynobiusguabangshanensissp .nov .。新种与安吉小鲵H amjiensis近似 ,它们体型较大 ;有 13条肋沟 ;前后肢贴体相向时指趾重叠较多 ;掌、突明显 ,但又有明显区别 :1)新种比安吉小鲵稍小 ,全长 139 32mm± 9 5 0mm (n=9) ;2 )犁骨齿细且排列密 ,外枝 9- 11枚、内枝 2 5 - 2 7枚 ;3)尾较短 ,平均为头体长之 70 4 % (n =9) ;4 )卵袋较短 ,香蕉形弯曲等。本文列表比较近似种 ,统计并记述了新种  相似文献   

4.
中国小鲵100年   总被引:7,自引:3,他引:4  
中国小鲵Hynobius chinensis是A.Gunther依据A.E.Pratt在中国湖北宜昌采到的两号标本,于1889年描述的种。由于描述依据的标本极少,描述亦较简单。试译如下:中国小鲵的原始描述“与日本产Hynobius nebulosus相近,但犁骨齿列较短,向后仅达眼球中部。体形短而壮;头大,长宽几相等,其长度大于躯干长的四分之一。尾侧扁而无鳍褶;肋沟11。前后肢贴体相向时彼此相遇;第五趾发达;无掌突及蹠突。皮肤平滑;颈褶不显著。背面几为均一的角黑色,腹面浅褐色,散以暗斑。全长85mm,吻端至泄殖肛孔46mm,头长11mm,头宽10mm,前肢15mm,后肢16mm,尾39mm。”中国…  相似文献   

5.
瘰螈属(有尾目,蝾螈科)一新种   总被引:2,自引:0,他引:2  
基于形态学差异、核POMC和线粒体序列分子数据,把分布于武陵山系的尾斑瘰螈种群定名为1新种,武陵瘰螈Paramesotriton wulingensis,其区别于尾斑瘰螈雷山种群(地模标本)鉴别特征为:1)新种体色较深,呈黑褐色,体背面疣粒较大,背脊隆起较低,尾斑瘰螈雷山地模标本体色较浅,呈棕黄色,体背面疣粒较小,背脊隆起较高;2)新种鼻突中间骨缝较深,尾斑瘰螈雷山地模标本鼻突中间骨缝较浅;3)新种前额骨与鼻骨相连的骨缝线呈波浪型,尾斑瘰螈雷山地模标本前额骨与鼻骨相连的骨缝线左右两侧呈明显“A”型;4)新种额鳞弧鳞骨直立前伸且背面观前粗后细,尾斑瘰螈雷山地模标本额鳞弧鳞骨水平前伸且背面观弧前后粗细一致;5)新种翼骨前枝较长达到上颌骨后缘,尾斑瘰螈雷山地模标翼骨前枝较短不到上颌骨后缘.  相似文献   

6.
根据一件产自云南罗平中三叠世关岭组Ⅱ段的新标本并结合产自相同地点和地层中的模式标本对纤细滇美龙(Dianmeisaurus gracilis Shang & Li,2015)进行了详细研究.原模式标本暴露其腹而,而新标本暴露其背面,两者互相补充提供了更完整、精确的纤细滇美龙解剖学信息.新材料揭示该种具有非常短小的吻部,眶前区的长度不仅短于眶后区长度,甚至短于眼眶的长度;外鼻孔小且位置靠前,即鼻孔前区的长度短于鼻孔后缘与眼眶前缘之间的距离;由两额骨构成的眼眶间隔非常狭窄,宽度小于顶骨平台宽度的1/3;额骨前后两端均具渐尖的突起;顶骨后部不收缩,顶骨平台后缘呈深V型.补充了新信息和包含更多属种(如Dawazisaurus)后的系统发育学分析支持了之前滇美龙和滇东龙互为姊妹群的结论,同时它们和马家山龙、滇肿龙、贵州龙和大洼子龙一起构成了一个仅由中国的属种组成的单系类群.与欧洲肿肋龙类群(Dactylosaurus,Anarosaurus,Serpianosaurus和Neusticosaurus)相比,这一单系类群与幻龙类有更近的亲缘关系.  相似文献   

7.
记述采自中国东北地区棘跳科1新纪录族小角棘跳族Oligaphorurini 1新种,三江双型棘跳Dimorphaphorura sanjiangensis sp.nov.及1新纪录种,北极小角棘跳Oligaphorura ursi Fjellberg,1984,附详细描述及特征图.研究标本保存于中国科学院东北地理与农业生态研究所湿地生态与环境重点实验室.三江双型棘跳,新种Dimorphaphorura sanjiangensis sp.nov.(图1 -11)鉴定特征 假单眼模式:身体背面32/033/333430,腹面11/000/000000,3对足第1亚基节分别具1个.拟单眼模式:身体背面不存在,腹面00/000/122203,3对足第1亚基节分别具两个.腹部第4节背面具2根中间毛(a0和m0),第5节背面不具中间毛,第6节背面具2根中间毛(a0和p0).腹管每侧具7根远端毛,2根基部毛,不具前端毛.弹器退化为1个颗粒状的区域,后面具1+1根毛.具臀刺,乳突不明显.正模♀,采自黑龙江省洪河农场的旱田大豆地土壤层中;2010-10-01,常亮等采.副模:3♀♀,1 ♂,特征与正模相同,采集地点及时间同正模.词源:新种种名源自模式标本采集地三江平原.北极小角棘跳Oligaphorura ursi Fjellberg,1984 中国新纪录(图12~19)鉴定特征 假单眼模式:身体背面32/133/333430,腹面11/000/000000,3对足第1亚基节上分别具1个.拟单眼模式:身体背面不存在,腹面00/000/122200,3对足第1亚基节上不存在.腹部第3、4节背面具或不具中间毛,数目存在变异;第5节背面通常不具中间毛,很少具中间毛m0;第6节背面具2根中间毛(a0和p0).腹管每侧具7根远端毛,2~5根基部毛,不具前端毛.弹器退化为一个表皮皱褶状结构,后面具2+2根毛呈两排排列.具臀刺,乳突较明显. 检视标本:15♀♀,采自黑龙江省前进农场的旱田大豆地土壤层中,2010-10-01,常亮等采;11♀♀,5♂♂,采自黑龙江省前进农场的小叶章草甸湿地土壤中,2011-05-26,武海涛等采.  相似文献   

8.
记述采自中国东北地区棘跳科1新纪录族小角棘跳族Oligaphorurini1新种,三江双型棘跳Dimorphaphorura sanjiangensis sp.nov.及1新纪录种,北极小角棘跳Oligaphoruraursi Fjellberg,1984,附详细描述及特征图。研究标本保存于中国科学院东北地理与农业生态研究所湿地生态与环境重点实验室。三江双型棘跳,新种Dimorphaphorura sanjiangensis sp.nov.(图1~11)鉴定特征假单眼模式:身体背面32/033/333430,腹面11/000/000000,3对足第1亚基节分别具1个。拟单眼模式:身体背面不存在,腹面00/000/122203,3对足第1亚基节分别具两个。腹部第4节背面具2根中间毛(a0和m0),第5节背面不具中间毛,第6节背面具2根中间毛(a0和p0)。腹管每侧具7根远端毛,2根基部毛,不具前端毛。弹器退化为1个颗粒状的区域,后面具1+1根毛。具臀刺,乳突不明显。正模♀,采自黑龙江省洪河农场的旱田大豆地土壤层中;2010-10-01,常亮等采。副模:3♀♀,1♂,特征与正模相同,采集地点及时间同正模。词源:新种种名源自模式标本采集地三江平原。北极小角棘跳Oligaphorura ursi Fjellberg,1984中国新纪录(图12~19)鉴定特征假单眼模式:身体背面32/133/333430,腹面11/000/000000,3对足第1亚基节上分别具1个。拟单眼模式:身体背面不存在,腹面00/000/122200,3对足第1亚基节上不存在。腹部第3、4节背面具或不具中间毛,数目存在变异;第5节背面通常不具中间毛,很少具中间毛m0;第6节背面具2根中间毛(a0和p0)。腹管每侧具7根远端毛,2~5根基部毛,不具前端毛。弹器退化为一个表皮皱褶状结构,后面具2+2根毛呈两排排列。具臀刺,乳突较明显。检视标本:15♀♀,采自黑龙江省前进农场的旱田大豆地土壤层中,2010-10-01,常亮等采;11♀♀,5♂♂,采自黑龙江省前进农场的小叶章草甸湿地土壤中,2011-05-26,武海涛等采。  相似文献   

9.
记乌米兽亚科 (Urmiatheriinae,Bovidae)一新属 :Lantiantraguslongirostralisgen .etsp .nov.。其主要特征是个体大 ;脸部窄而高 ;吻部细长 ,前颌骨与鼻骨接触 ;鼻骨狭长 ,背面平 ,前端无侧翼 ;鼻切迹位置靠前 ;眶下孔位置低 ,位于P3之上方 ;颊齿中等高冠 ,臼齿列长 ,前臼齿列与臼齿列之长度比小于 60 % ;一珐琅质中孔出现在磨蚀的上臼齿两叶之间 ,靠近唇侧 ;下第一门齿不增大 ;p4的下后尖指向后内 ,与下内尖相连 ;下臼齿具底柱 ;c~p2之间的齿隙长等。它出现在陕西蓝田灞河组下部 ,生存时代为晚中新世早期。  相似文献   

10.
贵州中三叠世早期幻龙属(Nothosaurus)一新种   总被引:3,自引:0,他引:3  
作为三叠纪海生爬行动物的重要分子,幻龙属化石主要发现于欧洲、中东和中国西南地区的中三叠世海相地层,且主要集中分布于安尼期晚期和拉丁期晚期(Edinger,1921;Haas,1980;Rieppel,2000)。我国目前已报道的幻龙属化石有两种:杨氏幻龙(Li and Rieppel,2004)和幻龙属未定种(Rieppel,1998),它们均产于贵州省兴义地区的法郎组竹杆坡段,时代为中三叠世拉丁期。最近在贵州省盘县地区关岭组Ⅱ段地层中也发现了数量较多的幻龙骨骼化石,证明中三叠世早期东特提斯区同样生存着幻龙类。鉴于标本的骨骼特征与已知的幻龙属种相比存在一定的差异,因此本文建立一新种Nothosaurus rostellatus sp.nov.(小吻幻龙)。新种的个体在幻龙属种中为中等(头骨中线长210~320mm);吻部短而小,具4个前颌骨獠齿,紧随其后是第5个明显较小的前颌齿;一对上颌骨犬齿之前有6~9个小型上颌齿;眼窝较大,卵圆形,位置相对靠前;内鼻孔的后缘由腭骨构成,具内鼻槽;外翼骨形成腹向凸缘;下颌具冠状突;背椎神经棘较低,背肋肩部明显加厚。N.rostellatus与其他已知种的主要区别特征是吻部形态和比例。新种的吻部较小,长略大于宽,前端钝圆,基部明显收缩,其吻部长度(从吻端至外鼻孔前端的距离)仅占其头骨中线长度的1/6~1/7,而其他种一般占1/4~1/5,具有细长吻部的N.haasi甚至接近1/3。此外,新种吻端-上颞孔前缘距离与吻端-外鼻孔前缘距离的比值也明显高于其他种。N.rostellatus区别于其他幻龙种的另一主要特征是上颌骨牙齿的数目和排列。在已知的幻龙属种中,很少有一对上颌犬齿前的上颌齿数超过5个者。新种正型标本ⅣPPⅤ14294在一对上颌犬齿前具有6个小型锥状上颌齿,它们大小相等,指向腹方。副型标本ⅣPPⅤ14301在一对上颌犬齿前具有9个小型锥状上颌齿。在已知的Nothosaurus中,新种与N.youngi Li & Rieppel,2004和N.marchicus Koken,1893无论是个体大小还是头骨形态均比较接近,如具有相对短而宽的吻部和较短的上颌齿列、相似的鼻骨形态等,与其他种相差较大,因此这里仅对新种与此二种之间的异同做简要的介绍。从头骨的一些具体形态特征看,N.rostellatus的鼻骨后侧方与前额骨相连,阻隔了额骨和上颌骨,该特征与N.youngi相同而不同于N.marchicus,后者鼻骨受额骨与上颌骨的阻隔,不与前额骨相连。如果不考虑鳞骨的外侧分支的宽度,Ⅴ14294和Ⅴ14301与N.youngi的头骨的最宽处均位于轭骨的后端位置,且其宽度为吻部宽度的2.6~3.5倍(其中N.youngi为2.6倍,Ⅴ14294为3倍,Ⅴ14301为3.5倍),而N.marchicus的最宽处位于头骨后部鳞骨的分支处,其轭骨后缘处头骨宽度为吻部宽度的2~2.8倍(Rieppel and Wild,1996,fig.36,41)。此外,N.rostellatus外翼骨形成腹向突起和下颌具冠状突的特点也与N.youngi相同,N.marchicus不具有该特征。另一方面,N.rostellatus的枕部特征则与N.marchicus接近而不同于N.youngi。新种的枕部内凹,枕骨侧边的后耳骨等向后侧部延伸,下颌关节在头骨后部位于枕髁之后,该枕部特征与N.marchicus一致。N.youngi的下颌关节与枕髁基本位于一个平面内,因此枕部未形成明显的内凹。新种的眼眶与上颞孔之间的距离相对较宽,其中V 14294眼眶与上颞孔之间的距离与外鼻孔与眼眶之间的距离接近相等,而V 14301眼眶与上颞孔之间的距离大于外鼻孔与眼眶之间的距离。此特征也与N.marchicus相同而不同于N.youngi,前者眼眶与上颞孔之间的距离与外鼻孔与眼眶之间的距离相等,后者的眶后弓很窄,其眼眶与上颞孔之间的距离小于外鼻孔与眼眶之间的距离的1/2。N.rostellatus鼻骨的左右两前突分别伸至两外鼻孔的前缘内侧,位置与N.marchicus相同,而N.youngi鼻骨前突仅伸至外鼻孔内侧缘的中部。N.rostellatus前颌骨的背突向后伸至外鼻孔后缘之后,接近鼻骨的后缘,而N.youngi仅伸至外鼻孔后缘中间部位。除前文所述新种两个主要鉴定特征外,N.rostellatus又以具有内鼻槽,翼骨前伸至内鼻槽附近等特征与该已知二种相区别。此外,新种前颌骨具外侧支突起,其他种该特征多不明显,如N.jagisteus不存在前颌骨外侧支突起,其前颌骨在外鼻孔的前外侧缘沿前外侧方向与上颌骨相交(Rieppel,2001)。从地理分布和地层层位看,N.marchicus主要分布于欧洲中部的中三叠统安尼阶,而N.youngi则分布于我国贵州南部的中三叠统拉丁阶。本文描述的化石产于贵州南部关岭组Ⅱ段,其时代应相当于中三叠世晚安尼期。N.rostellatus与分布于欧洲的同时期的幻龙N.marchicus以及与在其后约7~8Ma相邻地区出现的M.youngi的亲缘关系的远近可能还需要更深入的研究来证实。  相似文献   

11.
A new polynitro cage compound 2, 4, 6, 8, 10, 12, 13, 14, 15-nonanitro-2, 4, 6, 8, 10, 12, 13, 14, 15-nonaazaheptcyclo [5.5.1.1(3,11).1(5,9)] pentadecane (NNNAHP) was designed in the present work. Its molecular structure was optimized at the B3LYP/6-31 G(d,p) level of density functional theory (DFT) and crystal structure was predicted using the Compass and Dreiding force fields and refined by DFT GGA-RPBE method. The obtained crystal structure of NNNAHP belongs to the P-1 space group and the lattice parameters are a = 9.99 ?, b = 10.78 ?, c = 9.99 ?, α = 90.01°, β = 120.01°, γ = 90.00°, and Z = 2, respectively. Based on the optimized crystal structure, the band gap, density of state, thermodynamic properties, infrared spectrum, strain energy, detonation characteristics, and thermal stability were predicted. Calculation results show that NNNAHP has detonation properties close to those of CL-20 and is a high energy density compound with moderate stability.  相似文献   

12.
13.
The variation with age of the 18 trace element mass fractions and some histological characteristics of intact prostate glands of 50 subjects aged 0–30 years was investigated by instrumental neutron activation analysis, inductively coupled plasma atomic emission spectrometry, and a quantitative morphometric analysis. Mean values ± standard error of the mean (M ± SΕΜ) for the mass fractions (in milligrams per kilogram wet tissue) of these trace elements in pre-puberty were: Al 28.5 ± 9.0, B 0.40 ± 0.11, Ba 1.48 ± 0.44, Br 10.5 ± 1.5, Ca 241 ± 30, Cl 3,203 ± 278, Cu 3.51 ± 0.89, Fe 33.7 ± 4.1, K 2,364 ± 145, Li 0.020 ± 0.004, Mg 153 ± 23, Mn 0.46 ± 0.06, Na 2,286 ± 130, P 1,391 ± 100, S 1,698 ± 132, Si 62 ± 11, Sr 0.38 ± 0.08, and Zn 27.6 ± 2.3. During puberty and postpuberty, when there is a significant increase in circulating androgens, the mean values were: Al 7.2 ± 1.4, B 0.21 ± 0.05, Ba 0.25 ± 0.06, Br 5.8 ± 1.0, Ca 433 ± 81, Cl 2,314 ± 201, Cu 1.77 ± 0.13, Fe 20.9 ± 1.6, K 2,585 ± 118, Li 0.0088 ± 0.0014, Mg 232 ± 27, Mn 0.34 ± 0.04, Na 1,875 ± 107, P 1,403 ± 98, S 1,673 ± 73, Si 22.2 ± 3.1, Sr 0.22 ± 0.03, and Zn 93.3 ± 8.9. Mean values (M ± SΕΜ) of percent volumes (%) of the stroma, epithelium and lumen in the prostate before puberty were 73.4 ± 2.6, 20.4 ± 1.7, and 4.45 ± 0.94, respectively, versus 46.5 ± 2.5, 38.5 ± 1.9, and 14.9 ± 1.2 during puberty and postpuberty. This work’s results confirm that the Zn mass fraction in prostate tissue is an androgen-dependent parameter. For the first time it has been demonstrated that the glandular lumen is a main pool of Ca, Mg, and Zn accumulation and that the stroma is a main pool of Al, B, Ba, Br, Cl, Cu, Fe, Mn, Na, and Si accumulation in the normal human prostate, for the age range 0–30 years. It was concluded that the Ca, Mg, and Zn binds tightly within the prostatic fluid, because the volume of glandular lumen reflects the volume of prostatic fluid.  相似文献   

14.
Summary Concentration of N, P, K, Ca, Mg and S in summer groundnut crop was higher than in kharif while Zn, Fe, Mn and Cu contents were higher in summer crop. Kernel's N, P and Zn; Leaflet's Ca and Mn; Stem's K and Fe; Root's S and Cu and Petiole's Mg contents were highest. Shell's N, P, K, Mg, S, Zn and Cu; Kernel's Ca, Fe and Mn contents were the least. N, P, K, S, Zn and Cu concentrations decreased linearly as the crop grew. Ca, Mg, Fe and Mn concentrations did not display any distinct pattern. Ca concentration was positively correlated with pod yield in both the seasons.  相似文献   

15.
The goal of this article was to establish reference ranges of the concentration of trace elements in human serum and to compare these results with those reported by other authors. We describe the sample preparation and measurement conditions that allow the rapid, precise, and accurate determination of Al, As, B, Be, Cd, Co, Cu, Fe, Li, Mn, Mo, Ni, Rb, Se, Sr, and Zn in human serum samples (n=110) by inductively coupled plasma-mass spectrometry (ICP-MS). Accuracy and precision were determined by analyzing three reconstituted reference serum samples by comparison with other methods and by the standard addition procedure. The advantages of the ICP-MS method include short time of analysis of the elements mentioned, low detection limit, high precision, and high accuracy. Disadventages include a high risk of contamination due to the presence of some of the elements of interest in the environment, the relatively delicate sample handling, and the high cost of the equipment.  相似文献   

16.
The effect of age and gender on major, minor, and trace element contents in the intact rib bone of 80 relatively healthy 15–55-year-old women and men was investigated. Contents or upper limit of contents of 16 chemical elements in the rib bone were determined by inductively coupled plasma atomic emission spectrometry (ICP-AES). Mean values (M?±?SΕΜ) for the mass fraction of Ba, Ca, Cu, Fe, K, Li, Mg, Na, P, S, Sr, and Zn (milligram per kilogram of dry bone) were as follows: 2.54?±?0.16, 171,400?±?4,050, 1.35?±?0.22, 140?±?11, 1,874?±?71, 0.049?±?0.011, 2,139?±?38, 5,378?±?88, 75,140?±?1,660, 1,881?±?51, 291?±?20, and 92.8?±?1.5, respectively. The upper limits of contents of Al, B, Mn, and V were <7.20, <0.65, <0.36, and <0.03, respectively. Statistically significant tendency for the Ca, Mg, and P content to decrease with age was found in the human rib bone, regardless of gender. The mass fraction of Fe in the male rib bone increases with age. It was shown that higher Ca, Mg, Na, P, and Sr mass fractions as well as lower Fe content were typical of female ribs as compared to those in male ribs.  相似文献   

17.
《Ibis》1894,36(3):447-460
  相似文献   

18.
This report attempts to formulate reference ranges of elemental concentrations for 15 trace elements in selected human tissues and body fluids. A set of samples consisting of whole blood, blood serum, urine, milk, liver, and hair were chosen and considered for 15 elements of biological significance: As, Cd, Co, Cr, Cu, F, Fe, I, Hg, Mn, Mo, Ni, Pb, Se, and Zn. The results represent wholly or partially data received from 40 countries of the global regions of Africa, Asia, Europe, North, South, and Central America, Australia, and New Zealand. This survey, even if qualitative, has been useful in demonstrating certain trends of trace-element scenarios around the world. It is of course recognized that both diet and environment exert a strong influence on the distribution pattern of several elements, such as As, Cd, Mn, Pb, Se, and Zn. A limited comparison of the available information on soil status of different countries reflected some interesting associations for elements, such as Mn and Zn. Importantly, this study revealed that only a few countries were in a position to identify a reasonable amount of data on samples requested for this project. Regretably, for a number of countries, any dependable data for even such essential elements as Cu, Fe, and Zn were not available. In view of the nutritional importance of many elements, the time is ripe for concerted efforts by intergovernmental agencies to initiate investigations or commission task forces/projects to generate reliable reference data for selected global regions, which sadly lack data of any kind at present.  相似文献   

19.
Oral cancer is one of the main causes of cancer-related deaths in South-Asian countries. There are very limited treatment options available for oral cancer. Research endeavors focused on discovery and development of novel therapies for oral cancer, is necessary to control the ever rising oral cancer related mortalities. We mined the large pool of compounds from the publicly available compound databases, to identify potential therapeutic compounds for oral cancer. Over 84 million compounds were screened for the possible anti-cancer activity by custom build SVM classifier. The molecular targets of the predicted anti-cancer compounds were mined from reliable sources like experimental bioassays studies associated with the compound, and from protein-compound interaction databases. Therapeutic compounds from DrugBank, and a list of natural anti-cancer compounds derived from literature mining of published studies, were used for building partial least squares regression model. The regression model thus built, was used for the estimation of oral cancer specific weights based on the molecular targets. These weights were used to compute scores for screening the predicted anti-cancer compounds for their potential to treat oral cancer. The list of potential compounds was annotated with corresponding physicochemical properties, cancer specific bioactivity evidences, and literature evidences. In all, 288 compounds with the potential to treat oral cancer were identified in the current study. The majority of the compounds in this list are natural products, which are well-tolerated and have minimal side-effects compared to the synthetic counterparts. Some of the potential therapeutic compounds identified in the current study are resveratrol, nimbolide, lovastatin, bortezomib, vorinostat, berberine, pterostilbene, deguelin, andrographolide, and colchicine.  相似文献   

20.
We report 19 new species records for the faunal list of Coleoptera in New Brunswick, Canada, six of which are new records for the Maritime provinces, and one of which is new Canadian record. We also provide the first recent records for five additional species in New Brunswick. One new species of Stenotrachelidae, Cephaloon ungulare LeConte, is added to the New Brunswick faunal list. Additional records are provided for Cephaloon lepturides Newman, as well the first recent record of Nematoplus collaris LeConte. Two species of Oedemeridae, Asclera puncticollis (Say) and Asclera ruficollis (Say), are newly reported for New Brunswick, and additional locality and bionomic data are provided for Calopus angustus LeConte and Ditylus caeruleus (Randall). The records of Ditylus caerulus are the first recent records for the province. Three species of Meloidae, Epicauta pestifera Werner, Lytta sayi LeConte, and Meloe augustcollis Say are reported the first time for New Brunswick; Epicauta pestifera is newly recorded in Canada. Lacconotus punctatus LeConte and the family Mycteridaeis newly recorded for New Brunswick. The first recent records of Borus unicolor Say (Boridae) are reported from the province. One new species of Pythidae, Pytho siedlitzi Blair, and the first recent records of Pytho niger Kirby are added to the faunal list of New Brunswick. Three species of Pyrochroidae are newly reported for the province, including Pedilus canaliculatus (LeConte) and Pedilus elegans (Hentz), which are new for the Maritime provinces. Five species of Anthicidae and the first recent record of Anthicus cervinus LaFerté-Sénectére are newly reported for New Brunswick. Anthicus melancholicus LaFerté-Sénectère, Sapintus pubescens (LaFerté-Sénectère), Notoxus bifasciatus (LeConte), and Stereopalpus rufipes Casey are new to the Maritime provinces faunal list. Ambyderus granularis (LeConte) is removed from the faunal list of the province. Three species of Aderidae, Vanonus huronicus Casey, Zonantes fasciatus (Melsheimer), and Zonantes pallidusWerner, are newly recorded for New Brunswick; Zonantes fasciatus and Vanonus huronicus are new for the Maritime provinces' faunal list. Collection data, bionomic data, and distribution maps are presented for all these species.  相似文献   

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