Studies on Chemical Constituents of Fritillaria thunbergii Miq.

In our previous papers, it was reported that peimine, peiminine, eduardine and three new alkaloids, zhebeinine, zhebeirine, zhebeinone, were isolated from the bulbs of Fritillaria thunbergii Miq. In consecutive investigation of the plant, an additional new alkaloidal glucoside, 5α , 14α -cevanine-6α , 20β-dihydroxyl-3β-O-β-D-glucoside, named zhebeininoside (Ⅰ) and aknown picropodophyllotoxin (Ⅱ) were isolated. The structure of zhebeininoside was determined on the basis of spectral analysis and chemical reaction. Picropodophyllotoxin was firstly isolated from Fritillaria plants.     

Studies on Chemicai Constituents of Fritillaria thunbergii Miq.

In our previous paper, it was reported that peimine, peiminine and a new alkaloid, Zhebeinine, were isolated from the bulbs of Fritillaria thunbergii Miq. In consecutive investigation of the plant, an additional new alkloid, 5α, 14α-cevanine-3β-hydroxy-6-one, named zhebei rine(2) and a known eduardine (1) were isolated and the structure of zhebeirine was determined on the basis of spectral analysis. Eduardine(1) was firstly isolated from the bulbs.     

Steroidal Alkaloids from Sarcococca vagans

Sarcococca vagans Stapf (Buxaceae) was distributed in Southern Yunnan, China. From the plant collected in Xishuangbanna,three new steroidal alkaloids named vaganines A,B and C( Ⅰ–Ⅲ )together with three known compounds were isolated and on the basis of spectral analyses and chemical evidence, the chemical structures of three new compounds were determined as 20α-dimethylamino-4β-acetoxyl-3β-senecioylamino-5α-pregnane (Ⅰ), 20α-dimethylamino-4β hydroxyl- 3-senecioylamino-△2(3)-pregnaene (Ⅱ), acetate of Ⅱ (Ⅲ); respectively.     

The Glucosides from Swertia mussotii Franch

Swertia mussotii Franch. is a herb used for treatment of liver disease in Qinghai-Tibcran Plateau folk. Further investigation on chemical constituents in aqueous extract of Swertia mussotii Franch. has been reported here. Seven compounds (Ⅰ, Ⅲ–Ⅷ) were achieved except mangiferin (Ⅱ) isolated previously by a chromatograph. They belong in secoiridoids, flavonoids and xanthonoids, respectively. The structures of known compounds were identified as amarogentin(Ⅲ), swertisin(Ⅷ), 8-O-β-D-glucopyranosyl-1, 3, 5-trihydroxyxanthone(Ⅶ) and 8-O-β-D-glucopyranosyl-(1-6)-β-D-glucopyranosyl)-I, 7-dihydroxy-3-methoxyxanthone (Ⅵ). The structures of other three new compounds have been elucidated as 7-O-β-D-xylopy-ranosyl-1, 8-dihydroxy-3-methoxyxanthone (Ⅳ), 7-O-[α-L-rhamnopyranosyl- (1-2)-β-D-xylopyranosyl]-l,8-dihydroxy-3-methoxyxanthone(Ⅰ)and 3-O-β-D-glucopyranosy 1,8-dihydroxy-5-methoxyxanthone (Ⅴ), by means of the chemical and spectral methods. Mangiferin, amarogentin and 7-0- [α-L-rhamnopyranosyl-(1-2)-β-D-xylopyranosyl]-l,8-dihydroxy-3-methoxyxanthone are the principal glucosides in this plant.     

中越猕猴桃根化学成分研究

用溶剂提取和硅胶柱层析分离的方法 ,从中越猕猴桃 (Actinidiaindochinensis)的根部分分离得到 6个化合物 ,根据其理化性质和波谱分析 ,分别鉴定为 :2α,3α,2 4 三羟基 1 2 烯 2 8 齐墩果酸 (Ⅰ ) ,2α,3α 二羟基 1 2 烯 2 8 乌苏酸 (Ⅱ ) ,2α,3α ,1 9α 三羟基 1 2 烯 2 8 乌苏酸 (Ⅲ ) ,熊果酸 (Ⅳ ) ,β 谷甾醇 (Ⅴ ) ,和 β 胡萝卜甙(Ⅵ )。化合物Ⅰ、Ⅱ、Ⅲ、Ⅵ为首次从该植物中获得。其中化合物Ⅰ、Ⅱ为首次从该属植物获得。     

Studies on the Chemical Constituents of Rourea microphylla (Hook. et Arn) Planch.

Eleven compounds were isolated from the twigs and leaves of Rourea microphylla (Hook. et Arn) Planch. They were identified as quercetin-3-O-α-L-rhamnopyranoside (Ⅰ), hyperin (Ⅱ), quercetin (Ⅲ), astilbin (Ⅳ), β-sitosterol (Ⅴ), β-sitosteryl-β-D-glucopyranoside (Ⅵ), physcion (Ⅶ), erythroglaucin (Ⅷ), stearic acid (Ⅸ), palmitic acid (Ⅹ) and n-nonacosanane (Ⅺ) respectively, by means of UV, IR, NMR, MS spectra analyses and through chemical methods. The compounds Ⅰ, Ⅱ, Ⅲ, Ⅳ, Ⅵ, Ⅶ, Ⅷ, Ⅸ, Ⅹ and Ⅺ were first reportedin the Rourea genus.     

桂火绳中化学成分的研究

从梧桐科火绳属桂火绳中提取分离到22个化合物,经结构鉴定为:羽扇豆醇(1),白桦脂酸(2),齐墩果酸(3),丁香脂素(4),(+)-异落叶松树脂醇(5),东莨菪内酯(6),对羟基肉桂酸(7),二十七碳酸单甘油酯(8),2-十八烯酸单甘油酯(9),sitoindosideⅡ(10),儿茶素(11),表儿茶素(12),表儿茶素3-O-β-D-吡喃木糖甙(13),山奈酚3-O-β-D-吡喃葡萄糖甙(14),5,7,4'-三羟基异黄酮(15),4'-O-methylgallocatechin(16),反式-二氢槲皮素-3-O-α-阿拉伯糖甙(17),顺式-二氢槲皮素-3-O-α-阿拉伯糖甙(18),反式-二氢槲皮素-3-O-β-吡喃葡萄糖甙(19),3,5,7,3',5'-五羟基-4'-甲氧基异黄酮(20),山奈酚-3-O-β-D-吡喃葡萄糖(6→1)-α-L-吡喃鼠李糖甙(21),以及槲皮素3-O-β-D-吡喃葡萄糖(6→1)-β-D-吡喃葡萄糖甙(22),这些化学成分首次从该属植物中分离出来。     

青蕨化学成分的研究

从青蕨的乙酸乙酯提取物中分离得到6个化合物,通过化学方法及波谱分析,分别将其结构鉴定为木香素Ⅲ(1),7-甲氧基鬼灯擎素(2),扶桑甾醇(3),5-(3′-甲基丁基)-8-甲氧基呋喃香豆素(4),2-(3′-羟基-3′-甲基)丁基-4-羟基-5-甲氧基苯酚-1-O-β-D匍吡喃糖苷(青蕨素Ⅰ)(5)和2-(3′-羟基-3′-甲基)丁基-4-羟基-3,6-二甲氧基苯酚-1-O-β-D-匍吡喃糖苷(青蕨素Ⅱ)(6)。化合物5和6为新化合物,化合物1,2,3和4为首次从该植物中分离得到。     

三种毒菌的化学成分研究

本文对三种毒菌的化学成分进行了研究。从光盖伞(Psilocybe spp)分离鉴定了4个化合物,经波谱分析鉴定为:(22E,24R)-麦角甾-7,22-二烯-3β-十八烷酸酯(1)、β-胡萝卜苷(2)、(22E,24R)-5α,6α-环氧麦角甾-8,22-二烯-3β,7α-二醇(3)、色氨酸(4);从假褐云斑鹅膏(Amanita pseudoporphyria)分离鉴定了4个化合物:(22E,24R)-3β-羟基-5α,8α-过氧化麦角甾-6,22-二烯(5)、(22E,24R)-麦角甾-7,22-二烯-3β,5α,6β-三醇(6)、1-O-β-D-吡喃葡萄糖基-(2S,3R,4E,8E,2′R)-2-N-(2′-羟基棕榈酰)-9-甲基-4,8-脱氢鞘氨醇(7)、1-O-β-D-吡喃葡萄糖基-(2S,3R,4E,8E,2′R)-2-N-(2′-羟基十八烷酰)-9-甲基-4,8-脱氢鞘氨醇(8);大青褶伞(Chlorophyllum molybdites)发酵菌丝体分离鉴定了4个化合物:5、6、(22E,24R)-5α,6α-环氧麦角甾-8(14),22-二烯-3β,7α-二醇(9)、(22E,24R)-麦角甾-7,22-二烯-3β-醇(10)。除化合物9外其它化合物均为首次从以上相应毒菌中分离得到。     

高等真菌黑虎掌子实体的化学成分

黑虎掌 (Ｓａｒｃｏｄｏｎａｓｐｒａｔｕｍ (Ｂｅｒｋ .)Ｓ .Ｉｔｏ) ,又名香茸 ,是一种美味食用菌。近年来发现该属Ｓ .ｓｃａｂｒｏ ｓｕｓ (Ｆｒ.)Ｐ .Ｋａｒｓｔ.中含有对神经生长因子 (ＮＧＦ)的合成具有诱导作用的生物活性二萜 (Ｏｈｔ等 ,1998)。作为“高等真菌生物活性代谢产物研究”的一部分 ,我们对采自云南武定的样品进行了化学分析。从黑虎掌的新鲜子实体中分得 15个化合物。它们分别为ｃｅｒｅｂｒｏｓｉｄｅＢ (1) (12 0ｍｇ) ,阿洛酮糖腺苷(2 ) (12ｍｇ) ,三磷酸尿苷 (3) (7ｍｇ) ,尿嘧啶 (4 ) (12ｍｇ) ,腺嘌呤 (5 ) (8ｍ…     

非洲隔囊蚁巢伞的化学成分研究(英文)

从肯尼亚安波塞利产的隔囊蚁巢伞(Termitomyces schimperi)子实体中分离得到8个已知化合物,通过波谱方法鉴定它们的结构为(22E,24R)-麦角甾-5,7,22-三烯-3β-醇(1),(3β,5α,9α-三羟基麦角甾-7,22-二烯-6-酮(2),5α,8α-过氧-(22E,24R)-麦角甾-6,22-二烯-3β-醇(3),麦角甾-4,6,8(14),22-四烯-3-酮(4),D-阿拉伯糖醇(5),D-半乳糖醇(6),脑苷脂B(7)和脑苷脂D(8)。所有化合物均首次从该真菌中分离得到。     

海洋真菌Fusarium sp.次级代谢产物的研究

采用硅胶柱色谱、Sephadex LH-20凝胶柱色谱、开放ODS柱色谱以及HPLC等方法从海洋真菌Fusarium sp.的菌丝体中分离得到5个化合物,通过波谱数据及理化性质分别鉴定为3β,15β-二羟基-(22E,24R)-麦角甾-5,8(14),22-三烯-7-酮(1)、3β,5α,9α-三羟基-(22E,24R)-麦角甾-7,22-二烯-6-酮(2)、(22E,24R)-麦角甾-7,22-二烯-3β,5α,6β-三醇(3)、5α,8α-过氧-(22E,24R)-麦角甾-6,22-二烯-3β-醇(4)和丁二酸(5).其中化合物1和2首次从该属真菌中分离得到.     

中国红豆杉枝叶中的紫杉烷二萜

从中国红豆杉(Taxus chinensis)枝叶的乙醇提取物中分离得到8个紫杉烷二萜,通过波谱分析分别确定为：14p羟基巴卡亭Ⅵ(1),巴卡亭Ⅵ(2),巴卡亭Ⅳ(3),1β-去羟基巴卡亭Ⅳ(4),云南红豆杉酯甲(5),2α-去乙酰-2α-苯甲酰基-13α-乙酰基云南紫杉亭(6),5α-羟基-2α,7βp,9α,10β,13α-五乙酰氧基紫杉-4(20),11-二烯(7)和Taxaein(8)。其中化合物1为新化合物,并报道八个化合物在丙酮中测得的核磁共振信号,化合物8的数据属首次报道。     

天山棱子芹化学成分的研究

从天山棱子芹中首次分离得到15个已知化合物,通过NMR、MS及IR等波谱数据,分别鉴定为6,7-二羟基香豆素(1),( )-marmesin(2),marmesinin(3),5,7,4'-三羟基黄酮(4),莰非醇3-O-α-L-吡喃鼠李糖甙(5),藤黄菌素3'-O-β-D-吡喃葡萄糖甙(6),(R)-6-hydroxy-3-(2-hydroxypropan-2-yl)-6-methylcyclohex-2-enone(7),4-羟基苯甲酸(8),3-甲氧基4羟基苯甲酸(9),3-甲氧基-4,5-亚甲二氧基苯甲酸(10),丁香酸甲酯(11),丁香酸甲酯4-O-β-D-吡喃葡萄糖甙(12),姜油酮4’-O-β-D-吡喃葡萄糖甙(13),2-(4-羟基苯基)-乙醇(14)和正二十八醇(15)。其中化合物7为一新的天然产物。     

贵州紫云产黄花香茶菜的化学成分研究

采用甲醇回流提取和硅胶柱层析方法,从紫云产黄花香茶菜中分离得到6个化合物,结合1H-NMR、13C-NMR数据及文献资料鉴定为黄花香茶菜乙素(Ⅰ)、黄花香茶菜丁素(Ⅱ)、大萼变型香茶菜甲素(Ⅲ)、3β-Hydroxy-18α,19α-urs-20-en-28-oic acid(Ⅳ)、齐墩果酸(Ⅴ)和熊果酸(Ⅵ)。其中化合物Ⅳ为首次从该属植物中分离得到。     

二色补血草地上部分的化学成分

二色补血草﹝Limonium bicolor ( Bunge) Kuntze﹞为补血草属( Limonium Mill.)越年生草本植物,耐盐碱和抗逆性强,全草均可入药,具有补血止血、调经益气、抗菌消炎和温中健脾的作用[1],含有黄酮、多糖、挥发油和甾体等成分[2-7],其中,黄酮类成分具有较强的抗氧化能力,多糖对Hela细胞有明显抑制作用[8-11]。前人对二色补血草化学成分和药理活性已有一定研究,但对其地上部分的化学成分尚缺乏系统分析。为此,作者对二色补血草地上部分乙醇提取物进行了分离和鉴定,为该种的进一步开发利用和药理药效研究提供基础实验数据。     

云南产玉米须的化学成分研究

从玉米须60%乙醇提取液中分离得到了14个化合物,经波谱学方法分别鉴定为柯伊利素-7-O-β-D-葡萄糖苷(1)、柯伊利素-6-C-β-波伊文糖-7-O-β-葡萄糖苷(2)、柯伊利素-6-C-β-波伊文糖苷(3)、L-鼠李糖(4)、豆甾-4-烯-3β,6β-二醇(5)、7α-羟基谷甾醇(6)、7β-羟基谷甾醇(7)、胡萝卜苷棕榈酸酯(8)、大豆脑苷I(9)、7α-羟基谷甾醇-3-O-β-D-葡萄糖苷(10)、麦角甾-7,22-二烯-3β,5α,6β-三醇(11)、棕榈酸(12)、胡萝卜苷(13)和β-谷甾醇(14),其中化合物1、4和7～12为首次从玉米须中分离得到。     

Isolation and Indentification of Steroidal Saponins from Dioscorea zingiberensis Wright

Four known steroidal compounds were isolated from the rhizomes of Dioscorea zingiberensis Wright gathered from Hubei Province. Their structures were identified by means of spectroscopic analyses as Epi-smilagenin[Ⅰ]; 3-O-(β-D glucopyranosyl) diosgenin[Ⅱ]; 3-O-[β-D-glucopyranosyl (1→ 4)-β-D-glucopyranosyl-diosgenin[Ⅲ]; 3-O {β-D glucopyranosyl (1→ 3)-[α-L-rhamnopyranosyl (1 →2)]-β-D glucopyranosyl} diosgenin [Ⅳ].     

球药隔重楼的化学成分研究(英文)

采用硅胶柱层析、大孔吸附树脂、ODS柱层析、Sephadex LH-20和RP-C18柱层析等技术中分离得到8个化合物。通过波谱学数据和已知化合物数据比较,分别鉴定为β-谷甾醇(1),β-蜕皮激素(2),Paris SaponinsⅤ(3),Paris SaponinsⅠ(4),Paris SaponinsⅡ(5),Paris SaponinsⅦ(6),Paris Saponins H(7)和Paris SaponinsⅥ(8)。化合物1～8均为首次从球药隔重楼中分离得到。     

夏至草亲水性化学成分的研究

从夏至草正丁醇萃取物中分离得到6个化合物,运用光谱技术和化学方法鉴定了其中5个化合物的结构,其中1个为无机化合物KNO3（La1)另外4个为苯丙素甙,分别为purpureaside(La2),acteoside(La3),cistanoside B(La4),jionosideA(La5),均为首次从该属植物中获得。