三种毒菌的化学成分研究

本文对三种毒菌的化学成分进行了研究。从光盖伞(Psilocybe spp)分离鉴定了4个化合物,经波谱分析鉴定为:(22E,24R)-麦角甾-7,22-二烯-3β-十八烷酸酯(1)、β-胡萝卜苷(2)、(22E,24R)-5α,6α-环氧麦角甾-8,22-二烯-3β,7α-二醇(3)、色氨酸(4);从假褐云斑鹅膏(Amanita pseudoporphyria)分离鉴定了4个化合物:(22E,24R)-3β-羟基-5α,8α-过氧化麦角甾-6,22-二烯(5)、(22E,24R)-麦角甾-7,22-二烯-3β,5α,6β-三醇(6)、1-O-β-D-吡喃葡萄糖基-(2S,3R,4E,8E,2′R)-2-N-(2′-羟基棕榈酰)-9-甲基-4,8-脱氢鞘氨醇(7)、1-O-β-D-吡喃葡萄糖基-(2S,3R,4E,8E,2′R)-2-N-(2′-羟基十八烷酰)-9-甲基-4,8-脱氢鞘氨醇(8);大青褶伞(Chlorophyllum molybdites)发酵菌丝体分离鉴定了4个化合物:5、6、(22E,24R)-5α,6α-环氧麦角甾-8(14),22-二烯-3β,7α-二醇(9)、(22E,24R)-麦角甾-7,22-二烯-3β-醇(10)。除化合物9外其它化合物均为首次从以上相应毒菌中分离得到。

Chemical Constituents of Three Poisonous Mushrooms

Four known compounds were isolated from Psilocybe spp,which were identified as(22E,24R)-octadecylergos-ta-7,22-dien-3β-ol(1),β-daucosterol(2),(22E,24R)-5α,6α-epoxyergosta-8,22-diene-3β,7α-diol(3),tryptophan (4).Four known compounds were isolated from Amanita pseudoporphyria,which were identified as(22E,24R)-5α,8α-epidioxyergosta-6,22-dien-3β-ol(5),(22E,24R)-ergosta-7,22-dien-3β,5α,6β-triol(6),(2S,3R,4E,8E)-1-(O-β-D-glucopyranosyl)-3-hydroxy-2-(R)-2′-hydroxypalmitoyl]amino-9-methyl-4,8-octadecadiene(7),(2S,3R,4E,8E)-1-(O-β-D-ghcopyranosyl)-3-hydroxy-2-(R)-2′-hydroxyoctadecanoyl]amino-9-methyl-4,8-octadecadiene(8).Four known compounds were isolated from mycelium of Chlorophyllum molybdites,which were identified as 5,6,(22E,24R)-5α,6α-epoxxyergosta-8(14),22-diene-3β,7α-diol(9),(22E,24R)-ergosta-7,22-dien-3β-ol(10).This is the first time that compounds 1-8 and 10 were isolated from these tided mushrooms,respectively.