长柄山蚂蝗属新分类群和山蚂蝗属一新种名

勐腊长柄山蚂蝗 新种 图1 Podocarpium menglaense C.Chen et X.J.Cui,sp.nov. Species P.leptopo(A.Grar ex Benth.)Yang et Huang affinis,sed foliismajoribus,ovario stipitato,stipite 9—15mm longo,articulis 4—5,32—54mmlongis,3.5—4mm latis differt. Herba vel suffrutex erectus,50—100cm altus;caule simpleci,glabro,basilignescenti.Folia trifoliolata,stipulata;pctiolo sulcato,6—11cm longo.Foliolasubcoriacea,glabra,integra,supra viridia,subtus albo-maculata,nervis lateralibus5—6-jugis,marginem nequaquan attingentibus;foliolo terminali late ovato vellate elliptico,basi rotundato vel subcuneato,apice acuminato vel caudato-acuminato,     

疏花长柄山蚂蝗复合体(豆科)的修订

通过文献、标本研究,结合野外考察及数据统计分析,确认疏花长柄山蚂蝗复合体包括4种1亚种,讨论了各分类群的重要性状,并给出了新的检索表。将湘西长柄山蚂蝗(Hylodesmum laxum subsp.falfolium)处理为原亚种的新异名;订正了《中国植物志》和《Flora of China》等著作中该类群的几个错误的地理分布,记载了我国几个省区的分布新记录,并给出了凭证标本。     

豆科长柄山蚂蝗属一新组合

Ohashi和Mill提出长柄山蚂蝗属的正确学名是Hylodesmum H.Ohashi&R.R.Mill,用以取代由来已久的属名Podocarpium（Benth.）Y.C.Yang&P.H.Huang。本文根据该属属名的变化,提出并确定澜沧长柄山蚂蝗的新组合名称为Hylodesmum lancangense（Y.Y.Qian X.Y.Zhu&H.Ohashi。     

圆菱叶长柄山蚂蝗一新异名

摘要查阅了澜沧长柄山蚂蝗Hylodesmum lancangense (Y. Y. Qian) X. Y. Zhu & H. Ohashi的模式标本后,确认该种应归并入圆菱叶长柄山蚂蝗H. podocarpum (DC.) H. Ohashi & R. R. Mill ssp. podocarpum。     

中国豆科和樟科几种植物学名的订正

在编写《Flora of China》过程中,根据标本和文献的查阅,对国产豆科和樟科几种植物学名进行修订。本文记述5个新组合、4个新异名和一个恢复的种名。5个新组合是:垂果山蚂蝗Desmodium strigilosum var.pendenticarpum(C.Z.Gao Q.R.Lai) P.H.Huang,心叶山蚂蝗Desmodium flexuosum var.cordifoliolatum(P.C.Li) P.H.Huang,密毛长柄山蚂蝗Podocarpium densum(C.Chen et X.J.Cui)P.H.Huang,东北长柄山蚂蝗Podocarpium podocarpum var.mandshuricum(Maxim.) P.H.Huang和尖叶长柄山蚂蝗Podocarpium podocarpum var.japon-icum(Matsum.)P.H.Huang.4个新异名如下:李氏木姜子Litsea lii C.E.Chang及其变种能汉木姜子var.nunkao-tahangensis(Liao) Liao作为竹叶木姜子L.pseudoelongata Liou Ho的新异名,竹头角木姜子L.akosensis var.chitouchiaoensis Liao作为台湾木姜子L.hayatae Kanehira的新异名和密毛山蚂蝗Desmodium densum (C.Chen et X.J.Cui)H.Ohashi作为密毛长柄山蚂蝗Podocarpium densum (C.Chen et X.J.Cui)P.H.Huang的新异名。由于Litsea pedicellata一名被占用,恢复Litsea taiwaniana Kamikoti作为黄肉树合法的种名。     

广西山蚂蝗属一新种

本文发表了山蚂蝗属的一个新种,即Desmodium pendenticarpum C.Z.Gao et Q.R.Lai。     

药用山蚂蝗属植物的化学成分和药理活性研究进展

由于在中药中的广泛应用,近年来对豆科Leguminosae山蚂蝗属Desmodium Desv.植物的研究已成为热点。山蚂蝗属植物的化学成分主要包括黄酮类、生物碱类、萜类、甾醇类、烷类及各种烷衍生物等,具有抗氧化性、抗炎、镇痛解热、抗菌、抗虫、抗心脑血管疾病等药理活性。本文对山蚂蝗属中小槐花、广东金钱草、三点金、小叶三点金、假地豆、大叶山蚂蝗、饿蚂蝗等药用植物的研究进行总结,综述其化学成分及生物活性的研究进展,旨在为该属植物的进一步研究与利用提供参考。     

弥散山蚂蝗与大叶拿身草(豆科:蝶形花亚科)的分类学关系

弥散山蚂蝗Desmodium diffusum(新拟)不同于大叶拿身草D. laxiflorum,然而前者在中国却不被承认。弥散山蚂蝗广布于中国,与大叶拿身草相较更为普遍,而大叶拿身草仅分布于中国的广东、广西、台湾及云南南部。崔现举等将弥散山蚂蝗置于单序山蚂蝗D. unibotryosum种中。根据国际命名法规,单序山蚂蝗为一非法名称,属弥散山蚂蝗的异名。本文介绍了弥散山蚂蝗和大叶拿身草的分类历史、种的检索表、种的文献、异名及分布。同时,指定了弥散山蚂蝗的后选模式。     

广西广义山蚂蝗属部分种类的核型及染色体数目报道

本文分析了广义山蚂蝗属６种１变种的核型,并报道了９种１亚种的染色体数目。假地豆Ｄｅｓｍｏｄｉｕｍｈｅｔｅｒｏｃａｒｐｏｎ（Ｌ．）ＤＣ．,伏毛假地豆Ｄ．ｈｅｔｅｒｏｃｏｒｐｏ。（Ｌ．）ＤＣ．ｖａｒ．ｓｔｒｉｇｏｓｕｍｖａｎＭｅｅｕｗｅｎ,单叶假地豆Ｄ．ｒｕｂｒｕｍ（Ｌｏｕｒ．）ＤＣ．．金钱草Ｄ．ｓｔｙｒａｃｉｆｏｌｉｕｍ（Ｏｓｂｅｃｋ．）Ｍｅｒｒ．及假木豆Ｄｅｎｄｒｏｌｏｂｉｕｍｔｒｉａｎｇｕｌａｒｅ（Ｒｅｔｚ．）Ｓｃｈｉｎｄｌ．的核型均为Ｋ（２ｎ）＝２２＝２２ｍ,属１Ａ类型．但它们的染色体相对长度变化范围有一定的差异,假木豆的较大,假地豆的较小。舞草Ｃｏｄｏｒｉｏｃａｌｙｘｍｏｔｏｒｉｕｓ（Ｈｏｕｔｔ．）Ｏｈａｓｈｉ和圆叶舞草Ｃ．ｇｙｒｏｉｄｅｓ（Ｒｏｘｂ．ｅｘＬｉｎｋ．）Ｈａｓｓｋ．的核型为Ｋ（２ｎ）＝２２＝２２ｍ,有的细胞可见随体染色体,属１Ｂ类型．根据核型资料比较．作者发现狭义的舞草属比狭义的山蚂螟属和假木豆属较为进化。本文还报道大叶山蚂蝗ＤｅｓｍｏｄｉｕｍｌａｘｉｆｌｏｒｕｍＤＣ,波叶山蚂蝗Ｄ．ｓｅｑｕａｘＷａｌｌ．绒毛山蚂蝗Ｄ．ｖｅｌｕｔｉｎｕｍ（Ｗｉｌｌｄ．）ＤＣ,异叶山绿豆Ｄ．ｈｅｔｅｒｏｐｈ?     

云南草蔻和长柄山姜挥发油的化学成分分析

云南草蔻（Alpinia blepharocalyx K．Schum．）和长柄山姜（A．kwangsiensis T．L．Wu et Senjen）均为姜科山姜属多年生草本植物。云南草蔻,又名小草蔻,产自云南南部及西部,生于海拔100～1000m的疏林中;长柄山姜主要分布在广东、广西、贵州和云南,生于山谷中林下阴湿处,海拔580～680m。云南草蔻是傣药品种之一,种子以草豆蔻之名入药,根茎则用于治疗腹胀、腹部冷痛;长柄山姜根茎可治脘腹冷痛、胃寒呕吐。到目前为止,有关云南草蔻和长柄山姜根茎挥发油成分的研究尚未见报道。     

On the identity of Podogonium Heer 1857, nom. illeg. (Leguminosae) from the Miocene Shanwang flora of Shandong

The nomenclature and taxonomy of Podogonium Heer 1857, nom. illeg., a legume fossil widely distributed in the Neogene of Eurasia, were briefly reviewed. Herendeen's viewpoint that Podogonium Heer 1857 is a later synonym of Podocarpium A. Braun ex Stizenberger 1851 is supported. The genus possibly contains only one species, Podocarpium podocarpum (A. Braun) Herendeen 1992. Podogonium Heer 1857 should be no longer used as a conserved name. The specimens from the Miocene Shanwang flora of Shandong, which had been previously referred to Podogonium oehningense (Koenig) Kirchh. and P. knorrii (Braun) Heer, were re-investigated. The results suggest that these specimens are the same plant as the legume fossil from European Podocarpium podocarpum (A. Braun) Herendeen. Key words Leguminosae, Podogonium Heer 1857, Podocarpium A. Braun ex Stizenberger 1851, Podocarpium podocarpum (A. Braun) Herendeen 1992, Shanwang flora, Miocene. 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山东中新世山旺植物群中豆荚属的名实问题

简要回顾了欧亚新近系广泛分布的豆科化石植物豆荚属Podogonium Heer 1857,nom.illeg.的命名和分类.作者基本赞同Herendeen 1992年的观点,即Podogonium Heer 1857是Podocarpium A.Braun ex Stizenberger 1851一个晚出的异名.该属可能仅含有一个种--柄豆荚Podocarpium podocarpum（A.Braull）Herendeen.同时,Podogonium Heerl857也不宜作为保留名继续使用.作者重新调查了山东中新世山旺植物群中过去被鉴定为Podogonium oehningense（Koenig）Kirchh.和P. knorrii（Braun）Heer的标本,认为它们与欧洲发现的豆荚属应该为同一种植物,即柄豆荚.     

神经肽Y(NPY)的生理功能研究进展

神经肽Y(NPY)是机体内的一种重要且保守的神经递质,一般以前体形式存在,释放的有活性的NPY主要通过与其受体结合发挥作用。NPY受体包含了亚型Y1、Y2、Y3、Y4、Y5、Y6、Y7、Y8。Y1和Y2是NPY发挥收缩血管作用的关键受体;Y1、Y2和Y5是NPY调节动物摄食行为的关键受体;Y1、Y2和Y4是NPY调控动物焦虑、沮丧行为的必要受体。着重对NPY与其各种受体结合后如何行使动物的相关生理功能的情况进行了阐述。     

Distinct roles of the Y1 and Y2 receptors on neuropeptide Y-induced sensitization to sedation

Intracranial injection of neuropeptide Y (NPY) increases the sensitivity to sodium pentobarbital and ketamin sedation and has similar properties as GABA agonists on sleep. Mice sensitive to sedation have increased levels of NPY in many brain regions and Y1(-/-) mice show a marked resistance to barbiturates. Here we characterized the role of the NPY Y receptors in anesthetic-induced sedation. We show that Y1 and Y2, but not Y5, receptors participate in the modulation of sedation. Administration of a Y1 agonist increased the sodium pentobarbital-induced sedation and Y1(-/-) mice were less sensitive to this anesthetic. However, Y2(-/-) mice display increased sensitivity, showing that Y2 modulates GABAergic induced sedation both pharmacologically and physiologically and has a functionally opposing role to the Y1 receptor. Analysis of Y1(-/-)/Y2(-/-) double mutant mice show that increased sensitivity by Y1 occurs independent of the Y2 receptor, while the decreased sensitivity mediated by Y2 depend on an intact Y1 receptor. In contrast to sodium pentobarbital, both Y1 and Y2 receptors increase the sensitivity in a collaborative fashion to NMDA antagonist-induced sedation. These data demonstrate the physiological and pharmacological impact of the Y1 and Y2 receptors on sedation.     

Current knowledge on the nucleotide agonists for the P2Y2 receptor

P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular nucleotides. There are eight mammalian P2Y receptor subtypes (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and P2Y14). P2Y2 receptors are widely expressed and play important roles in multiple functionalities. Diquafosol tetrasodium, known as INS365, which was the first P2Y2 receptor agonists that had been approved in April 2010 and launched in Japan by Santen Pharmaceuticals. Besides, a series of similar agonists for the P2Y2 receptor are undergoing development to cure different diseases related to the P2Y2 receptor. This article illustrated the structure and functions of the P2Y2 receptor and focused on several kinds of agonists about their molecular structures, research progress and chemical synthesis methods. Last but not the least, we summarized the structures-activity relationship (SAR) of agonists for the P2Y2 receptor and expected more efficient agonists for the P2Y2 receptor.     

Y1 and Y5 receptors are both required for the regulation of food intake and energy homeostasis in mice

Neuropeptide Y (NPY) acting in the hypothalamus is one of the most powerful orexigenic agents known. Of the five known Y receptors, hypothalamic Y1 and Y5 have been most strongly implicated in mediating hyperphagic effects. However, knockout of individual Y1 or Y5 receptors induces late-onset obesity--and Y5 receptor knockout also induces hyperphagia, possibly due to redundancy in functions of these genes. Here we show that food intake in mice requires the combined actions of both Y1 and Y5 receptors. Germline Y1Y5 ablation in Y1Y5(-/-) mice results in hypophagia, an effect that is at least partially mediated by the hypothalamus, since mice with adult-onset Y1Y5 receptor dual ablation targeted to the paraventricular nucleus (PVN) of the hypothalamus (Y1Y5(Hyp/Hyp)) also exhibit reduced spontaneous or fasting-induced food intake when fed a high fat diet. Interestingly, despite hypophagia, mice with germline or hypothalamus-specific Y1Y5 deficiency exhibited increased body weight and/or increased adiposity, possibly due to compensatory responses to gene deletion, such as the decreased energy expenditure observed in male Y1Y5(-/-) animals relative to wildtype values. While Y1 and Y5 receptors expressed in other hypothalamic areas besides the PVN--such as the dorsomedial nucleus and the ventromedial hypothalamus--cannot be excluded from having a role in the regulation of food intake, these studies demonstrate the pivotal, combined role of both Y1 and Y5 receptors in the mediation of food intake.     

Characterisation of tyrosine-phosphorylation-defective calmodulin mutants

Using site-directed mutagenesis, we have produced three calmodulin (CaM) mutants in which one or the two tyrosine residues of native CaM were substituted by phenylalanine. The three variants, denoted CaM(Y99F), CaM(Y138F), and CaM(Y99F/Y138F), were highly expressed in transformed Escherichia coli BL21(DE3)pLysS and purified in high yield. The three CaM mutants were able to activate the cyclic nucleotide phosphodiesterase and the plasma membrane Ca(2+)-ATPase, and present the characteristic Ca(2+)-induced electrophoretic mobility shift of native CaM. CaM(Y138F) and CaM(Y99F/Y138F), however, showed a slightly higher electrophoretic mobility than CaM(Y99F) or wild type CaM. The molar extinction coefficient of native CaM at 276 nm decreases 50% in CaM(Y99F) and CaM(Y138F), while the 276nm peak disappears in CaM(Y99F/Y138F). Terbium fluorescence studies with the different CaM mutants indicate that Y99 (but not Y138) closely interacts with Ca(2+) in the III Ca(2+)-binding domain. The epidermal growth factor receptor (EGFR) and the non-receptor tyrosine kinase c-Src phosphorylate CaM(Y99F) and CaM(Y138F) at a lesser extent than wild type CaM, while they fail to phosphorylate CaM(Y99F/Y138F) as expected. All resulting phospho-(Y)CaM species present the characteristic Ca(2+)-induced electrophoretic mobility shift observed in non-phosphorylated CaM. Quantitative analysis of the different phospho-(Y)CaM species suggests that the relative phosphorylation of Y99 and Y138 in wild type CaM by both the EGFR and c-Src is different than the respective phosphorylation of either Y99 in CaM(Y138F) or Y138 in CaM(Y99F).     

On the Type of the Genus Yinshania (Cruciferae)

When the genus Yinshania Ma et Y. Z. Zhao was published, it had only a single species, Y. albiflora Ma et Y. Z. Zhao which was indicated as the type of the genus (Acta Phytotax. Sin. 1979). Y. Z. Zhao 155. was indicated as the type specimen of Y. albiflora. It is adequate to cite Y. albiflora Ma et Y. Z. Zhao as the type of genus Yinshania Ma et Y. Z. Zhao. In a revision (Acta Phytotax. Sin. 25(3): 204-219, 1987) Y. H. Zhang made a combintion, Yinshania acutangula (O. E. Schulz) Y. H. Zhang (=Cochlearia acutangula O. E. Schulz) and reduced Yinshania albiflora Ma et Y. Z. Zhao as a variety of Y. acutangula,i. e. Y. acutangula var. albiflora (Ma et Y. Z. Zhao) Y. H. Zhang. She is uncorrect, however, when she cited Y. acutangula (O. E. Schulz) Y. H . Zhang as the type of the genus Yinshania Ma et Y. Z. Zhao. It should be cited as follows: Yinshania Ma et Y. Z. Zhao Typus generis: Yinshania albiflora Ma et Y. Z. Zhao (=Yinshania acutangula(O. E. Schulz) Y. H. Zhang var. albiflora (Ma et Y. Z. Zhao) Y. H. Zhang)     

Freeze-fracture electron microscopic studies of age-related plasma membrane changes in Sporothrix schenckii

Characteristics of the plasma membrane of Sporothrix scheckii cells as revealed by freeze-fracture techniques have been classified into eight types (Y1, Y2a, Y2b, Y3a, Y3b, Y4a, Y4b, and Y5) in yeastlike cells grown under the following two conditions: brain heart infusion agar medium at 27 degrees C, and brain heart infusion agar medium at 37 degrees C. Type Y1 cells are yeastlike cells having smooth plasma membranes without any invagination. Typical characteristics of the other types are as follows: type Y2a, smooth plasma membranes with few trenchlike invaginations; type Y2b, wavy plasma membranes with few oval or irregularly formed invaginations; type Y3a, plasma membranes with many randomly distributed trenchlike invaginations; type Y3b, plasma membranes with many cocoonlike or irregularly formed invaginations; type Y4a, plasma membranes with longer trenchlike invaginations; type Y4b, plasma membranes with irregularly formed, enlarged invaginations; and type Y5, smooth or wavy plasma membranes with aggregations of intramembranous particles and with many vacuoles between cell walls and plasma membranes or in the cytoplasm in some cells. By counting the proportion of each type of yeastlike cell under the two conditions and with different cultivation periods, it appears that plasma membrane types change as aging progresses in the following order: type Y1, Y2a, Y3a, Y4a, and Y5 in conidia and type Y1, Y2b, Y3b, Y4b, and Y5 in yeastlike vegetative cells. These observations provide us with an important advantage when studying the effects of antifungal agents on the plasma membrane of Sporothrix scheckii, as it is important to know the natural course of changes in membrane structure during aging.