| 皮质酮对体外培养的海马神经元延迟整流钾电流的影响 |
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| 作者姓名： | Wang J Ma Q Liu HT |
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| 作者单位： | 军事医学科学院卫生学环境医学研究所,天津,300050 |
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| 摘 要： | 目的：探讨应激激素皮质酮对海马神经元延迟整流钾电流的影响。方法：膜片钳全细胞记录测量原代培养大鼠海马神经元膜的钾离子电流。结果：在皮质酮的作用下,海马神经元膜的钾离子电流幅度明显下调,激活阈电位升高。结论：过量皮质酮激素可能通过影响延迟整流钾通道损伤海马神经元。
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| 关 键 词： | 皮质酮 体外培养 海马神经元 延迟整流钾电流 |
| 文章编号： | 1000-6834(2003)03-0253-03 |
| 修稿时间： | 2002年5月29日 |
Effect of corticosterone on the delayed rectified potassium currents of cultured rat hippocampal neurons in vitro |
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| Wang J,Ma Q,Liu HT.Effect of corticosterone on the delayed rectified potassium currents of cultured rat hippocampal neurons in vitro[J].Chinese Journal of Applied Physiology,2003,19(3):253-255. |
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| Authors: | Wang Jing Ma Qiang Liu Hong-Tao |
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| Institution: | Institute of Health and Environmental Medicine, Academy of Military Medical Sciences, TianJin 300050, China. |
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| Abstract: | Aim: The effect of stress hormone corticosterone on hippocampal neurons delayed rectified potassium currents was probed. Methods: The potassium currents of rat hippocampal neurons in primary culture were measured with patch clamp whole cell recording. Results: It showed that the amplitudes of the potassium currents in hippocampal neurons decreased. However, the threshold potential of potassium currents increased. Conclusion:It is speculated that excessive corticosterone may hurt the hippocampal neurons via its effects on the potassium currents of rat hippocampal cells. |
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| Keywords: | corticosterone hippocampal neurons delayed rectified potassium currents |
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