全文获取类型
收费全文 | 1489篇 |
免费 | 131篇 |
国内免费 | 94篇 |
出版年
2024年 | 4篇 |
2023年 | 51篇 |
2022年 | 54篇 |
2021年 | 101篇 |
2020年 | 99篇 |
2019年 | 85篇 |
2018年 | 89篇 |
2017年 | 46篇 |
2016年 | 41篇 |
2015年 | 113篇 |
2014年 | 121篇 |
2013年 | 122篇 |
2012年 | 50篇 |
2011年 | 70篇 |
2010年 | 41篇 |
2009年 | 74篇 |
2008年 | 70篇 |
2007年 | 87篇 |
2006年 | 52篇 |
2005年 | 50篇 |
2004年 | 40篇 |
2003年 | 42篇 |
2002年 | 42篇 |
2001年 | 25篇 |
2000年 | 20篇 |
1999年 | 13篇 |
1998年 | 14篇 |
1997年 | 10篇 |
1996年 | 12篇 |
1995年 | 11篇 |
1994年 | 10篇 |
1993年 | 5篇 |
1992年 | 6篇 |
1991年 | 6篇 |
1990年 | 5篇 |
1989年 | 7篇 |
1988年 | 3篇 |
1987年 | 3篇 |
1986年 | 5篇 |
1985年 | 3篇 |
1984年 | 3篇 |
1983年 | 2篇 |
1982年 | 3篇 |
1980年 | 1篇 |
1978年 | 1篇 |
1977年 | 2篇 |
排序方式: 共有1714条查询结果,搜索用时 15 毫秒
1.
2.
3.
《Current biology : CB》2020,30(18):3657-3663.e5
Media player
4.
5.
6.
7.
Marta Balog Allison Anderson Thiago C. Genaro-Mattos Zeljka Korade Karoly Mirnics 《Journal of lipid research》2022,63(8):100249
Polypharmacy, or the simultaneous use of multiple drugs to treat a single patient, is a common practice in psychiatry. Unfortunately, data on the health effects of commonly used combinations of medications are very limited. In this study, we therefore investigated the effects and interactions between two commonly prescribed psychotropic medications with sterol inhibiting side effects, trazodone (TRZ), an antidepressant, and aripiprazole (ARI), an antipsychotic. In vitro cell culture experiments revealed that both medications alone disrupted neuronal and astroglial sterol biosynthesis in dose-dependent manners. Furthermore, when ARI and TRZ were combined, exposure resulted in an additive 7-dehydrocholesterol (7-DHC) increase, as well as desmosterol (DES) and cholesterol decreases in both cell types. In adult mice, at baseline, we found that the three investigated sterols showed significant differences in distribution across the eight assessed brain regions. Furthermore, experimental mice treated with ARI or TRZ, or a combination of both medications for 8 days, showed strong sterol disruption across all brain regions. We show ARI or TRZ alone elevated 7-DHC and decreased DES levels in all brain regions, but with regional differences. However, the combined utilization of these two medications for 8 days did not lead to additive changes in sterol disturbances. Based on the complex roles of 7-DHC derived oxysterols, we conclude that individual and potentially simultaneous use of medications with sterol biosynthesis-inhibiting properties might have undesired side effects on the adult brain, with as yet unknown long-term consequences on mental or physical health. 相似文献
8.
Antony M. Jose 《BioEssays : news and reviews in molecular, cellular and developmental biology》2020,42(7):1900254
Our view of heredity can potentially be distorted by the ease of introducing heritable changes in the replicating gene sequences but not in the cycling assembly of regulators around gene sequences. Here, key experiments that have informed the understanding of heredity are reinterpreted to highlight this distortion and the possible variety of heritable changes are considered. Unlike heritable genetic changes, which are always associated with mutations in gene sequence, heritable epigenetic changes can be associated with physical or chemical changes in molecules or only changes in the system. The transmission of cycling stores along the continuous lineage of cells that connects successive generations creates waves of activity and localization of the molecules that together form the cell code for development in each generation. As a result, heritable epigenetic changes can include any that can alter a wave such as changes in form, midline, frequency, amplitude, or phase. Testing this integrated view of all heritable information will require the concerted application of multiple experimental approaches across generations. 相似文献
9.
Whole body energy balance is achieved through the coordinated regulation of energy intake and energy expenditure in various tissues including liver, muscle and adipose tissues. A positive energy imbalance by excessive energy intake or insufficient energy expenditure results in obesity and related metabolic diseases. Although there have been many obesity treatment trials aimed at the reduction of energy intake, these strategies have achieved only limited success because of their associated adverse effects. An ancient neurotransmitter, serotonin is among those traditional pharmacological targets for anti-obesity treatment because it exhibits strong anorectic effect in the brain. However, recent studies suggest the new functions of peripheral serotonin in energy homeostasis ranging from the endocrine regulation by gut-derived serotonin to the autocrine/paracrine regulation by adipocyte-derived serotonin. Here, we discuss the role of serotonin in the regulation of energy homeostasis and introduce peripheral serotonin as a possible target for anti-obesity treatment. 相似文献
10.