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Deregulation of ER-mitochondria contact formation and mitochondrial calcium homeostasis mediated by VDAC in fragile X syndrome
Institution:1. Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA;2. Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai 200240, China;3. Shanghai Key Laboratory of Psychotic Disorders (No. 13dz2260500), Shanghai Mental Health Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China;1. Department of Ophthalmology, University of California, San Francisco, San Francisco, CA 94143, USA;2. Center of Human and Molecular Biology and Center for Molecular Signaling, Department of Medical Biochemistry and Molecular Biology, Saarland University School of Medicine, Homburg, Germany;3. Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA;1. Department of Biological Sciences, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan;2. Institute of Biotechnology, National Tsing Hua University, Hsinchu 30013, Taiwan;3. Brain Research Center, National Tsing Hua University, Hsinchu 30013, Taiwan;4. Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung 80780, Taiwan;5. Institute of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli 35053, Taiwan;6. Graduate Institute of Clinical Medical Science, China Medical University, Taichung 40402, Taiwan;7. Kavli Institute for Brain and Mind, University of California San Diego, La Jolla, CA 92093-0526, USA;1. Department of Genetics, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA;2. Precision Research Center for Refractory Diseases, Institute for Clinical Research, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China;3. Cardiovascular Research Center, School of Basic Medical Sciences, Jiaotong University, Xi’an 710061, China;4. Department of Pharmacology and Therapeutics, McGill University, Montreal, QC H3G 1Y6, Canada;5. Departments of Neurology and Neuroscience, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA;6. Departments of Pediatrics and Medicine, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA;1. Department of Molecular Pathology, Oncode Institute, Netherlands Cancer Institute, Amsterdam, 1066 CX, the Netherlands;2. The Maastricht Multimodal Molecular Imaging Institute, Maastricht University, Maastricht, 6229 ER, the Netherlands;3. Mouse Clinic for Cancer and Aging, the Netherlands Cancer Institute, Amsterdam, 1066 CX, the Netherlands;1. State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China;2. Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China;3. Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, China;4. State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China;5. School of Chemistry and Materials Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, China;1. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA;2. Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA;3. Department of Molecular, Cellular & Developmental Biology, Yale University, New Haven, CT, USA
Abstract:
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  • Keywords:fragile X syndrome  FXS  fragile X messenger ribonucleoprotein  FMRP  voltage-dependent anion channel  VDAC  ER-mitochondria contact site  ERMCS  mitochondrial calcium homeostasis
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