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1.
俞立 《中国细胞生物学学报》2019,(2):174-174
细胞是结构与功能的统一体,细胞内繁复的生化反应通过膜性与非膜性细胞器组织起来,而细胞内亚结构之间又通过膜运输等方式进一步组织成一个整体。对细胞内组织原则的探索一直是细胞生物学领域的前沿方向,每一个对细胞组织方式的新认识,都会催生大量的新发现。在这个综述系列中,中国科学院生物物理研究所的胡俊杰研究员和清华大学的李丕龙教授及其共同作者概述了细胞器互作及相分离这两个近年来细胞组织方式方向上的重要的概念性突破,并探讨了这些突破对细胞生物学领域的可能影响。 相似文献
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蛋白质-蛋白质相互作用是蛋白质发挥其功能的重要途径之一。作者基于相互作用蛋白质数据库、基因本体数据库和蛋白质结构分类数据库(structural classification of proteins, SCOP),结合SWISS-PROT等相关数据库中蛋白质功能注释信息,定义描述蛋白质相互作用倾向性的参数,对酿酒酵母定位于不同细胞器蛋白、部分膜蛋白,以及酿酒酵母、线虫和大肠杆菌按SCOP分类的不同结构类蛋白质之间相互作用规律进行研究。结果表明各种细胞器、膜和结构类蛋白质之间相互作用确实存在明显的偏向性。 相似文献
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内质网和高尔基体都是膜构成的细胞器,二者在形态、化学组成上都有一定的相似性。其功能虽然有一定的联系,但也有很大的差别。许多中学生乃至大学生对二者功能上的区别与联系不甚明了。下面就分别加以论述。 相似文献
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Recent studies have demonstrated that chloroplasts and mitochondria evoke specific Ca2+ signals in response to biotic and abiotic stresses in a stress-dependent manner. The identification of Ca2+ transporters and Ca2+signaling mol- ecules in chloroplasts and mitochondria implies that they play roles in controlling not only intra-organellar functions, but also extra-organellar processes such as plant immunity and stress responses. It appears that organellar Ca2+ signaling might be more important to plant cell functions than previously thought. This review briefly summarizes what is known about the molecular basis of Ca2+ signaling in plant mitochondria and chloroplasts. 相似文献
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Most of the mitochondrial and chloroplastic proteins are synthesized in the cytosol as precursor proteins carrying an N-terminal targeting peptide (TP) directing them specifically to a correct organelle. However, there is a group of proteins that are dually targeted to mitochondria and chloroplasts using an ambiguous N-terminal dual targeting peptide (dTP). Here, we have investigated pattern properties of import determinants of organelle-specific TPs and dTPs combining mathematical multivariate data analysis (MVDA) with in vitro organellar import studies. We have used large datasets of mitochondrial and chloroplastic proteins found in organellar proteomes as well as manually selected data sets of experimentally confirmed organelle-specific TPs and dTPs from Arabidopsis thaliana. Two classes of organelle-specific TPs could be distinguished by MVDA and potential patterns or periodicity in the amino acid sequence contributing to the separation were revealed, dTPs were found to have intermediate sequence features between the organelle-specific TPs. Interestingly, introducing positively charged residues to the dTPs showed clustering towards the mitochondrial TPs in silico and resulted in inhibition of chloroplast, but not mitochondrial import in in vitro organellar import studies. These findings suggest that positive charges in the N-terminal region of TPs may function as an 'avoidance signal' for the chloroplast import. 相似文献
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Lipid droplets (LDs) were once viewed as simple, inert lipid micelles. However, they are now known to be organelles with a rich proteome involved in a myriad of cellular processes. LDs are heterogeneous in nature with different sizes and compositions of phospholipids, neutral lipids and proteins. This review takes a focused look at the roles of proteins involved in the regulation of LD formation, expansion, and morphology. The related proteins are summarized such as the fat-specific protein (Fsp27), fat storage-inducing trans- membrane (FIT) proteins, seipin and ADP-ribosylation factor 1-coat protein complex I (Arf-COPI). Finally, we present important challenges in LD biology for a deeper understanding of this dynamic organelle to be achieved. 相似文献