| Abstract: | Lipid droplets(LDs) were once viewed as simple, inert lipid micelles. However, they are now known to be organelles with a rich proteome involved in a myriad of cellular processes. LDs are heterogeneous in nature with different sizes and compositions of phospholipids, neutral lipids and proteins. This review takes a focused look at the roles of proteins involved in the regulation of LD formation,expansion, and morphology. The related proteins are summarized such as the fat-specific protein(Fsp27), fat storage-inducing transmembrane(FIT) proteins, seipin and ADP-ribosylation factor 1-coat protein complex I(Arf-COPI). Finally, we present important challenges in LD biology for a deeper understanding of this dynamic organelle to be achieved. |
