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《上海生物医学工程》2007,28(1):11-11
全俄电气工艺研究所的专家研制的简易外科装置——冷等离子氩凝结器,今年获得国际发明大会银奖。这种装置可在手术中起止血作用,同时能对伤口消毒,进而促进伤口尽快愈合。 相似文献
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家兔中脑导水管周围灰质中注射八肽胆囊收缩素(CCK—8)拮抗吗啡镇痛和... 总被引:4,自引:0,他引:4
We have reported that intracerebroventricular (i. c. v.) injection of 1-4 ng of CCK-8 to the rat produced a remarkable antagonistic effect on morphine analgesia. In order to study the species specificity and the site of action, CCK-8 was microinjected into the PAG of the rabbit, and its influence on morphine analgesia and electroacupuncture analgesia was observed. The latency of the escape response (ERL) to radiant heat focused on the snout was measured as an index of the pain threshold. Microinjections were made via cannulae chronically implanted into the PAG. The drug solutions were delivered in a volume of 1 microliter, at a speed of 0.125 microliter/min. The ERL was measured for a period of 60 or 70 minutes at 10 min intervals. 1. CCK-8 administered unilaterally to the PAG of the rabbit at a dose of 3 ng antagonized the analgesia induced by morphine (4 mg/kg, i. v.) by 73% (P less than 0.001), and reduced the analgesic effect of electroacupuncture by 67% (P less than 0.001). These effects were dose-dependent within the range from 1.5 ng to 6.0 ng. The effect of CCK-8 was reversed by CCK receptor blocker proglumide (4 microliters, intra-PAG injection). Unsulfated CCK-8 (CCK-us) had no effect in this regard. These results indicate that in the PAG of the rabbit, exogenously administered CCK-8 was capable of antagonizing opioid analgesia by the activation of CCK receptors. 2. Two groups of rabbits were given with morphine (2 mg/kg, i. v.) and simultaneous injection of CCK-8 antiserum (CCK-AS, 1 microliter) or normal rabbit serum (NRS) into the PAG.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
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Cortical potentials evoked by stimulation of the contralateral tooth-pulp were recorded epidurally from the SI cortex of rabbits anesthetized with urethane and chloralose. It was found that nociceptive components of the evoked potential consisted of P1 and P2 wavelets with a relative stable peak latency of 22.5 +/- 1.2 ms and 66.1 +/- 1.9 ms respectively. Higher intensity of tooth pulp stimulation was required for appearance of P2 than P1. Diazepam, a non-analgesic sedative, reduced P1 but not P2 amplitude. On the contrary, dolantin, an analgesic, suppressed P2 but showed no significant influence on P1. The results suggest that P2, but not P1 might be related to pain. The effects of l-tetrahydropalmatine (1-THP) and electroacupuncture on P2 were observed on 12 animals. The results showed that both iv l-THP 8mg/kg and electroacupuncture brought forth a decrease in P2 amplitude by 40.3 +/- 14% and 59.3 +/- 10% respectively, while electroacupuncture combined with l-THP produce a further decrease in P2 amplitude by 92.8 +/- 7%. Furthermore, the inhibitory periods of P2 amplitude were significantly prolonged after electroacupuncture combined with l-THP. The results indicated that l-THP enhanced the suppression of P2 by electroacupuncture. 相似文献
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大鼠杏仁核内注射八肽胆囊收缩素(CCK—8)拮抗吗啡镇痛的研究 总被引:2,自引:0,他引:2
大鼠双侧杏仁核内注射CCK-81ng(1μl),能明显降低皮下注射4mg/kg吗啡产生的镇痛作用,并在0.1-1ng范围内呈量效关系。分别向双侧仁核注射CCK-A受体拮抗剂Devazepide50ng能部分翻转,200ng则完全翻转CCK-8的抗吗啡镇痛作用,10ng无效;而CCK-B受体拮抗剂L-365,260在5-8ng时即可完全番转CCK-8的抗吗啡镇痛作用。杏仁核注射200ng的Devaz 相似文献
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吗啡降低大鼠脊髓内cAMP的含量 总被引:1,自引:0,他引:1
有资料表明,吗啡或脑啡肽可影响脑内 cAMP 与 cGMP 的含量,但对脊髓内 cAMP 与cGMP 的含量有何影响,未见报道。本实验采用放射免疫分析(RIA)方法研究的结果表明,吗啡可使大鼠离体与在体脊髓内 cAMP 的含量明显降低;而对脊髓内 cGMP 的含量则无明显影响;纳洛酮可特异阻断吗啡对脊髓内 cAMP 含量的抑制效应。提示:吗啡的上述作用是通过大鼠脊髓内阿片受体所介导。脑和脊髓内 cAMP 含量的变化可能部分介导了吗啡作用的中枢机制。 相似文献
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目的:探讨活血温经止痛法治疗寒凝血瘀型原发性痛经的临床效果。方法:选取2009年9月~2011年9月在我院门诊部接受治疗的寒凝血瘀型原发性痛经患者56例,随机将所有患者分为研究组和对照组各28例,对照组:选用芬必得布洛芬缓释胶囊进行治疗,研究组给予患者少腹逐瘀汤为主药随症加减治疗。结果:治疗结束后,对照组的总有效率为75.0%,研究组的总有效率为92.9%,两组比较差异显著,具有统计学意义(P<0.05)。研究3个月后的复发情况明显优于对照组。讨论:少腹逐瘀汤治疗寒凝血瘀型原发性痛经不仅临床疗效显著,而且复发率低,安全可靠,值得推广 相似文献