人类情绪或可影响干细胞生长

<正>南方医科大学南方医院杨默课题组发现,影响人类情绪和抑郁症的血清素与骨髓干细胞的生长分化及移植有密切关系。相关成果近日发表在《干细胞》杂志上。课题组根据研究结果提出:影响人类情绪与抑郁症的血清素与骨髓干细胞的生长分化及移植有密切关系。情绪低落可导致血清素下降,引起干细胞功能受损,影响损伤细胞修复和血细胞再生,从而影响身体免疫功能。这是医学界首次从科学角度证实人类情绪与干细胞生长之间     

A Putative Calcium-Permeable Cyclic Nucleotide-Gated Channel, CNGC18, Regulates Polarized Pollen Tube Growth

A tip-focused Ca^2＋ gradient is tightly coupled to polarized pollen tube growth, and tip-localized influxes of extracellular Ca^2＋ are required for this process. However the molecular identity and regulation of the potential Ca^2＋ channels remains elusive. The present study has implicated CNGC18 （cyclic nucleotide-gated channel 18） in polarized pollen tube growth, because its overexpression induced wider and shorter pollen tubes. Moreover, CNGC18 overexpression induced depolarization of pollen tube growth was suppressed by lower extracellular calcium （[Ca^2＋]ex）. CNGC18-yellow fluorescence protein （YFP） was preferentially localized to the apparent post-Golgi vesicles and the plasma membrane （PM） in the apex of pollen tubes. The PM localization was affected by tip-localized ROP1 signaling. Expression of wild type ROP1 or an active form of ROP1 enhanced CNGC18-YFP localization to the apical region of the PM, whereas expression of RopGAP1 （a ROP1 deactivator） blocked the PM localization. These results support a role for PM-Iocalized CNGC18 in the regulation of polarized pollen tube growth through its potential function in the modulation of calcium influxes.