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排序方式: 共有702条查询结果,搜索用时 15 毫秒
1.
I C Dormehl H Bosman N Hugo M Maree C van Vuuren C van Zandwyk A van Aswegen L Paterson 《Journal of medical primatology》1987,16(3):139-150
Thermodilution cardiac output determinations and multigated equilibrium blood-pool scintigraphy were performed in ten healthy chacma baboons (Papio ursinus). The correlation was moderately good between both the radionuclide and thermodilution stroke volume (r = 0.58, SEE = 3 ml; SVth = 0.78SVr + 15.6 ml) as well as the cardiac output (r = 0.72, SEE = 0.2 liter/min; COth = 0.56 Cor + 2.1 liter/min). The attenuation depth dr as determined by radionuclide techniques was found to correlate well with the radiologically determined values dx (r = 0.8, SEE = 0.4 cm; dx = 0.87dr + 0.72 cm) which validated the depth values used in the calculations. 相似文献
2.
Paul L. Wood Tadimeti S. Rao Smriti Iyengar Thomas Lanthorn Joseph Monahan Alex Cordi Eric Sun Michael Vazquez Nancy Gray Patricia Contreras 《Neurochemical research》1990,15(2):217-230
Conclusions Current neurochemical studies of the NMDA receptor macromolecular complex are yielding new insights into the interactions of the subunits of this complex and the associated potential clinical benefits of selective modulation of these subnits. Such studies offer the great potential for a new generation of pharmacotherapies for a wide range of CNS disorders, including stroke, a condition for which there is currently no effective pharmacological treatment. However, it is essential to understand that the first generation products in this area may not be optimal pharmacotherapies, such that haracterization of possible receptor subtypes and understanding the molecular biology of the component proteins of the receptor complex will be crucial in the design of the optimal pharmacological modulators of the NMDA receptor complex.Special issue dedicated to Dr. Erminio Costa 相似文献
3.
Ma Rosario de la Torre Angela Casado Ma Encarnación López-Fernández Diana Carrascosa Ma Concepción Casado Domenico Venarucci Vincenzo Venarucci 《Neurochemical research》1996,21(8):885-888
In order to investigate the role of two free radical detoxificant enzymes in patients with aging brain disorders, superoxide
dismutase (SOD) and catalase (CAT) activities have been measured in blood from male and female human patients of different
ages with several types of aging brain disorders. When compared with activities in the normal population, we have detected:
1) SOD and CAT activities are decreased in patients with Parkinson disease. 2) SOD activity seems to be normal and CAT activity
is decreased in patients with dementia. 3) In the patients with stroke, SOD activity is normal, while CAT activity is decreased.
SOD activity was measured in red blood cells using the Minami and Yoshikawa method. CAT activity was measured in hemolysates
by the method of Aebi. We can conclude that SOD and CAT activities in patients with Parkinson disease are decreased. 相似文献
4.
Yangyang Xu Jie Zhang Fei Gao Wenna Cheng Ye Zhang Chuanmei Wei Shuping Zhang Xinfu Gao 《Journal of cellular and molecular medicine》2023,27(12):1653-1663
High-mobility group box1 (HMGB1) induces inflammatory injury, and emerging reports suggest that it is critical for brain ischemia reperfusion. Engeletin, a natural Smilax glabra rhizomilax derivative, is reported to possess anti-inflammatory activity. Herein, we examined the mechanism of engeletin-mediated neuroprotection in rats having transient middle cerebral artery occlusion (tMCAO) against cerebral ischemia reperfusion injury. Male SD rats were induced using a 1.5 h tMCAO, following by reperfusion for 22.5 h. Engeletin (15, 30 or 60 mg/kg) was intravenously administered immediately following 0.5 h of ischemia. Based on our results, engeletin, in a dose-dependent fashion, reduced neurological deficits, infarct size, histopathological alterations, brain edema and inflammatory factors, namely, circulating IL-1β, TNF-α, IL-6 and IFN-γ. Furthermore, engeletin treatment markedly reduced neuronal apoptosis, which, in turn, elevated Bcl-2 protein levels, while suppressing Bax and Cleaved Caspase-3 protein levels. Meanwhile, engeletin significantly reduces overall expressions of HMGB1, TLR4, and NF-κB and attenuated nuclear transfer of nuclear factor kappa B (NF-κB) p65 in ischemic cortical tissue. In conclusion, engeletin strongly prevents focal cerebral ischemia via suppression of the HMGB1/TLR4/NF-κB inflammatory network. 相似文献
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摘要 目的:探讨依达拉奉右莰醇联合丁苯酞对老年大动脉粥样硬化(LAA)型脑卒中患者血清五聚素3(PTX3)、脂蛋白相关磷脂酶A2(Lp-PLA2)以及微栓子信号(MES)的影响。方法:回顾性选取2021年9月-2022年9月在本院收治的120例老年LAA型脑卒中患者,根据其不同治疗方案分为对照组(56例),采用依达拉奉右莰醇单独治疗,和观察组(64例),采用依达拉奉右莰醇联合丁苯酞治疗。观察两组患者的临床疗效;对比两组患者治疗前后神经功能[脑卒中量表(NIHSS)及中枢神经特异性蛋白(S-100β)、神经元特异性烯醇化酶(NSE)]状态、炎症因子[血清五聚素3(PTX3)、脂蛋白相关磷脂酶A2(Lp-PLA2)]水平及脑血流微栓子信号(MES)阳性率变化。记录不良反应发生情况。结果:观察组患者治疗有效率为95.31%,高于对照组的78.57%(χ2=7.653 ,P=0.006);治疗后,观察组患者NIHSS评分、S-100β及NSE水平低于对照组(P<0.05);观察组PTX3、Lp-PLA2水平及MES阳性率低于对照组(P<0.05)。观察组与对照组总不良反应发生率比较无差异(6.25 % vs 5.36 %)(Fisher=1.000)。结论:依达拉奉右莰醇联合丁苯酞可有效提高临床疗效,促进老年LAA型患者神经功能恢复,降低PTX3、lp-PLA2水平及MES阳性率,控制病情发展,且安全性较好。 相似文献
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8.
Bruce L. Wilson Glenn L. Albright Ph.D. Solomon S. Steiner John L. Andreassi 《Applied psychophysiology and biofeedback》1991,16(1):45-53
In the present study 36 police officers were exposed to a psychological stressor (IQ quiz) and to cold pressor stress while several cardiovascular variables were monitored. Impedance cardiography was used to provide measures of heart rate, stroke volume, cardiac output, myocardial contractility, and total peripheral resistance. In addition, measures of systolic and diastolic blood pressure and peripheral skin temperature were obtained. A multivariate analysis of variance (MANOVA) indicated that significant increases in diastolic and systolic blood pressure during the cold pressor test were mediated by large increases in total peripheral resistance, whereas blood pressure elevation during the IQ quiz were accompanied by significant increases in heart rate and, to a lesser extent, cardiac output. Peripheral skin temperature decreased in response to each stressor. Additional analysis indicated a degree of stimulus specificity for several variables. For example, diastolic blood pressure showed greater increases to cold pressor than quiz, whereas systolic blood pressure increased more with the psychological than the physical stressor. Directional fractionation occurred for both myocardial contractility and cardiac output. 相似文献
9.
Austin A. Robinson Kevin Ikuta Jonathan Soverow 《The Yale journal of biology and medicine》2014,87(2):199-206
Few prospective studies support the use of anticoagulation during the acute phase of ischemic stroke, though observational data suggest a role in certain populations. Depending on the mechanism of stroke, systemic anticoagulation may prevent recurrent cerebral infarction, but concomitantly carries a risk of hemorrhagic transformation. In this article, we describe a case where anticoagulation shows promise for ischemic stroke and review the evidence that has discredited its use in some circumstances while showing its potential in others. 相似文献
10.
Kuan‐Hung Chen Kun‐Chen Lin Sheung‐Fat Ko John Y. Chiang Jun Guo Hon‐Kan Yip 《Journal of cellular and molecular medicine》2020,24(18):10402-10419
This study tested the hypothesis that melatonin (Mel) therapy preserved the brain architectural and functional integrity against ischaemic stroke (IS) dependently through suppressing the inflammatory/oxidative stress downstream signalling pathways. Adult male B6 (n = 6 per each B6 group) and TLR4 knockout (ie TLR4?/?) (n = 6 per each TLR4?/? group) mice were categorized into sham control (SCB6), SCTLR4?/?, ISB6, ISTLR4?/?, ISB6 + Mel (i.p. daily administration) and ISTLR4?/? + Mel (i.p. daily administration). By day 28 after IS, the protein expressions of inflammatory (HMBG1/TLR2/TLR4/MAL/MyD88/RAM TRIF/TRAF6/IKK‐α/p‐NF‐κB/nuclear‐NF‐κB/nuclear‐IRF‐3&7/IL‐1β/IL‐6/TNF‐α/IFN‐γ) and oxidative stress (NOX‐1/NOX‐2/ASK1/p‐MKK4&7/p‐JNK/p‐c‐JUN) downstream pathways as well as mitochondrial‐damaged markers (cytosolic cytochrome C/cyclophilin D/SRP1/autophagy) were highest in group ISB6, lowest in groups SCB6 and SCTLR4?/?, lower in group ISTLR4?/? + Mel than in groups ISTLR4?/? and ISB6 + Mel and lower in group ISB6 + Mel than in group ISTLR4?/? (all P < .0001). The brain infarct volume, brain infarct area and the number of inflammatory cells in brain (CD14/F4‐88) and in circulation (MPO+//Ly6C+/CD11b+//Ly6G+/CD11b+) exhibited an identical pattern, whereas the neurological function displayed an opposite pattern of inflammatory protein expression among the six groups (all P < .0001). In conclusion, TLR inflammatory and oxidative stress signallings played crucial roles for brain damage and impaired neurological function after IS that were significantly reversed by Mel therapy. 相似文献