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Human aging brain disorders: Role of antioxidant enzymes |
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| Authors: | Ma Rosario de la Torre Angela Casado Ma Encarnación López-Fernández Diana Carrascosa Ma Concepción Casado Domenico Venarucci Vincenzo Venarucci |
| Institution: | 1. Centro de Investigaciones Biológicas (CSIC), c/Velázquez 144, 28006, Madrid, Spain 2. Centro de Salud INSALUD, Casas Iba?ez, Albacete, Spain 3. I.N.R.C.A. Sede di Fermo, Italy |
| Abstract: | In order to investigate the role of two free radical detoxificant enzymes in patients with aging brain disorders, superoxide dismutase (SOD) and catalase (CAT) activities have been measured in blood from male and female human patients of different ages with several types of aging brain disorders. When compared with activities in the normal population, we have detected: 1) SOD and CAT activities are decreased in patients with Parkinson disease. 2) SOD activity seems to be normal and CAT activity is decreased in patients with dementia. 3) In the patients with stroke, SOD activity is normal, while CAT activity is decreased. SOD activity was measured in red blood cells using the Minami and Yoshikawa method. CAT activity was measured in hemolysates by the method of Aebi. We can conclude that SOD and CAT activities in patients with Parkinson disease are decreased. |
| Keywords: | Cu/Zn superoxide dismutase catalase stroke Parkinson Alzheimer dementia |
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