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排序方式: 共有238条查询结果,搜索用时 15 毫秒
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2.
Behzad Davarniya Hao Hu Kimia Kahrizi Luciana Musante Zohreh Fattahi Masoumeh Hosseini Fariba Maqsoud Reza Farajollahi Thomas F. Wienker H. Hilger Ropers Hossein Najmabadi 《PloS one》2015,10(8)
Cognitive impairment or intellectual disability (ID) is a widespread neurodevelopmental disorder characterized by low IQ (below 70). ID is genetically heterogeneous and is estimated to affect 1–3% of the world’s population. In affected children from consanguineous families, autosomal recessive inheritance is common, and identifying the underlying genetic cause is an important issue in clinical genetics. In the framework of a larger project, aimed at identifying candidate genes for autosomal recessive intellectual disorder (ARID), we recently carried out single nucleotide polymorphism-based genome-wide linkage analysis in several families from Ardabil province in Iran. The identification of homozygosity-by-descent loci in these families, in combination with whole exome sequencing, led us to identify possible causative homozygous changes in two families. In the first family, a missense variant was found in GRM1 gene, while in the second family, a frameshift alteration was identified in TRMT1, both of which were found to co-segregate with the disease. GRM1, a known causal gene for autosomal recessive spinocerebellar ataxia (SCAR13, MIM#614831), encodes the metabotropic glutamate receptor1 (mGluR1). This gene plays an important role in synaptic plasticity and cerebellar development. Conversely, the TRMT1 gene encodes a tRNA methyltransferase that dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl methionine as the methyl group donor. We recently presented TRMT1 as a candidate gene for ARID in a consanguineous Iranian family (Najmabadi et al., 2011). We believe that this second Iranian family with a biallelic loss-of-function mutation in TRMT1 gene supports the idea that this gene likely has function in development of the disorder. 相似文献
3.
In this work, we introduce a deep-structured conditional random field (DS-CRF) model for the purpose of state-based object silhouette tracking. The proposed DS-CRF model consists of a series of state layers, where each state layer spatially characterizes the object silhouette at a particular point in time. The interactions between adjacent state layers are established by inter-layer connectivity dynamically determined based on inter-frame optical flow. By incorporate both spatial and temporal context in a dynamic fashion within such a deep-structured probabilistic graphical model, the proposed DS-CRF model allows us to develop a framework that can accurately and efficiently track object silhouettes that can change greatly over time, as well as under different situations such as occlusion and multiple targets within the scene. Experiment results using video surveillance datasets containing different scenarios such as occlusion and multiple targets showed that the proposed DS-CRF approach provides strong object silhouette tracking performance when compared to baseline methods such as mean-shift tracking, as well as state-of-the-art methods such as context tracking and boosted particle filtering. 相似文献
4.
Hajibarat Zahra Saidi Abbas Hajibarat Zohreh Talebi Reza 《Physiology and Molecular Biology of Plants》2015,21(3):365-373
Physiology and Molecular Biology of Plants - To evaluate the genetic diversity among 48 genotypes of chickpea comprising cultivars, landraces and internationally developed improved lines genetic... 相似文献
5.
Hosseini Zohreh Habibi Najafi Mohammad Bagher Yavarmanesh Masoud Ataei-Pirkooh Angila 《International journal of peptide research and therapeutics》2020,26(2):911-919
International Journal of Peptide Research and Therapeutics - LL-37 is a 37 amino acid long cationic peptide belonging to the cathelicidin family of antimicrobial peptides. Limited investigations... 相似文献
6.
Zohreh Jahanafrooz Jaffar Mosafer Morteza Akbari Mahmoud Hashemzaei Ahad Mokhtarzadeh Behzad Baradaran 《Journal of cellular physiology》2020,235(5):4153-4166
Despite many advances and optimization in colon cancer treatment, tumor recurrence and metastases make the development of new therapies necessary. Colon cancer stem cells (CCSCs) are considered as the main triggering factor of cancer progression, recurrence, and metastasis. CCSCs as a result of accumulated genetic and epigenetic alterations and also complex interconnection with the tumor microenvironment (TME) can evolve and convert to full malignant cells. Mounting evidence suggests that in cancer therapy both CCSCs and non-CCSCs in TME have to be regarded to break through the limitation of current therapies. In this regard, stem cell capabilities of some non-CCSCs may arise inside the TME condition. Therefore, a deep knowledge of regulatory mechanisms, heterogeneity, specific markers, and signaling pathways of CCSCs and their interconnection with TME components is needed to improve the treatment of colorectal cancer and the patient's life quality. In this review, we address current different targeted therapeutic options that target cell surface markers and signaling pathways of CCSCs and other components of TME. Current challenges and future perspectives of colon cancer personalized therapy are also provided here. Taken together, based on the deep understanding of biology of CCSCs and using three-dimensional culture technologies, it can be possible to reach successful colon cancer eradication and improvise combination targeted therapies against CCSCs and TME. 相似文献
7.
Zohreh S. Tabatabayi Masoud Homayouni-Tabrizi Ali Neamati S. Ali Beyramabadi 《Journal of cellular biochemistry》2020,121(3):2677-2689
Herein, a Mn(II) complex of the N,N′-dipyridoxyl(1,4-butanediamine) (═H2L) Schiff base has been newly synthesized. The synthesized complex was characterized by several experimental methods. In addition, the density functional theory approaches were used for theoretical identification of the complex. A good agreement between the computed and experimental infrared frequencies demonstrates validity of the optimized geometry for the synthesized complex. In a N2O2 manner, two azomethine nitrogens and two phenolate oxygens of the L2− ligand are coordinated to the Mn2+ metal ion. The biological studies indicate an efficient apoptotic and antioxidant activities of the synthesized [MnL(CH3OH)2] complex on both of the HepG2 and MCF7 cancer cells. Since it has been suggested that the complex is an exclusive potent antitumor for treatment of the human breast and liver cancers. 相似文献
8.
Hadi Mozafari Zohreh Rahimi Azadeh Heidarpour Mahsa Fallahi Adraiana Muniz 《Molecular biology reports》2009,36(8):2361-2364
It has been suggested that the allele frequency of thrombophilic mutations is affected by glucose-6-phosphate dehydrogenase
(G6PD) deficiency. The prevalence of thrombophilic mutations were studied in sixty G6PD deficient individuals including 57
males and three females with the mean age of 15 ± 3.08 and 110 age and sex matched healthy individuals consisted of 95 males and 15 females with
the mean age of 16.19 ± 2.17 from the Kermanshah Province of Iran. Using a combination of PCR-RFLP technique, single strand
conformation polymorphism (SSCP) analysis and DNA sequencing polymorphic G6PD mutations were identified. The factor V Leiden,
prothrombin G20210A and methylenetetrahydrofolate reductase (MTHFR) C677T were detected by PCR-RFLP method using MnlI, HindIII
and HinfI restriction enzymes, respectively. Three mutations, G6PD Mediterranean, G6PD Chatham and G6PD Cosenza were identified
in 60 G6PD deficient individuals with highest prevalence of G6PD Mediterranean (91.6%). In G6PD deficient individuals the
prevalence of factor V Leiden tended to be higher (5%) compared to healthy individuals (2.7%). The prevalence of prothrombin
G20210A mutation in G6PD deficient individuals was 1.7%. However, in normal subjects the prevalence of this mutation was 2.7%.
The frequency of T allele in G6PD deficient individuals were insignificantly higher (29.16%) than those in healthy individuals
(26.8%). Our finding indicates that the prevalence of factor V Leiden, prothrombin G20210A and MTHFR C677T in G6PD deficient
individuals is not statistically different compared to normal subjects and G6PD deficiency is not associated with these thrombophilic
mutations in Western Iran. 相似文献
9.
Hamid Reza Esmaeili Zohreh Ganjali Malihatozaman Monsefi 《Environmental Biology of Fishes》2009,84(1):141-145
We studied the reproductive biology of the endemic Iranian cichlid Iranocichla hormuzensis, a maternal mouthbrooder, in the Mehran River. Overall sex ratio was 1.44 M: 1F indicating a significant male bias. Monthly
sex ratios did not differ from unity except in May and June when the sex ratios were strongly biased in favor of males. Four
different reproductive indices and the high frequency of large oocytes, all suggest that the Iranian cichlid spawns at the
end of winter and the beginning of spring. Mircoscopic gonadal maturation stages for both males and females were correlated
to the gonadosomatic indices. The maximum number of larvae in the mouth of a female was 153. 相似文献
10.
Mitra Kheirabadi Zohreh Sharafian Hossein Naderi-Manesh Udo Heineman Ulrich Gohlke Saman Hosseinkhani 《Biochimica et Biophysica Acta - Proteins and Proteomics》2013,1834(12):2729-2735
Firefly bioluminescence reaction in the presence of Mg2 +, ATP and molecular oxygen is carried out by luciferase. The luciferase structure alterations or modifications of assay conditions determine the bioluminescence color of firefly luciferase. Among different beetle luciferases, Phrixothrix hirtus railroad worm emits either yellow or red bioluminescence color. Sequence alignment analysis shows that the red-emitter luciferase from Phrixothrix hirtus has an additional arginine residue at 353 that is absent in other firefly luciferases. It was reported that insertion of Arg in an important flexible loop350–359 showed changes in bioluminescence color from green to red and the optimum temperature activity was also increased. To explain the color tuning mechanism of firefly luciferase, the structure of native and a mutant (E354R/356R/H431Y) of Lampyris turkestanicus luciferase is determined at 2.7 Å and 2.2 Å resolutions, respectively. The comparison of structure of both types of Lampyris turkestanicus luciferases reveals that the conformation of this flexible loop is significantly changed by addition of two Arg in this region. Moreover, its surface accessibility is affected considerably and some ionic bonds are made by addition of two positive charge residues. Furthermore, we noticed that the hydrogen bonding pattern of His431 with the flexible loop is changed by replacing this residue with Tyr at this position. Juxtaposition of a flexible loop (residues 351–359) in firefly luciferase and corresponding ionic and hydrogen bonds are essential for color emission. 相似文献