全文获取类型
收费全文 | 241篇 |
免费 | 21篇 |
国内免费 | 91篇 |
出版年
2024年 | 1篇 |
2023年 | 4篇 |
2022年 | 10篇 |
2021年 | 12篇 |
2020年 | 5篇 |
2019年 | 12篇 |
2018年 | 8篇 |
2017年 | 5篇 |
2016年 | 9篇 |
2015年 | 16篇 |
2014年 | 26篇 |
2013年 | 24篇 |
2012年 | 31篇 |
2011年 | 29篇 |
2010年 | 20篇 |
2009年 | 24篇 |
2008年 | 19篇 |
2007年 | 20篇 |
2006年 | 21篇 |
2005年 | 12篇 |
2004年 | 12篇 |
2003年 | 10篇 |
2002年 | 8篇 |
2001年 | 2篇 |
2000年 | 2篇 |
1997年 | 3篇 |
1996年 | 2篇 |
1995年 | 2篇 |
1994年 | 1篇 |
1985年 | 1篇 |
1983年 | 1篇 |
1950年 | 1篇 |
排序方式: 共有353条查询结果,搜索用时 31 毫秒
1.
2.
3.
4.
Wei Song Wei Wang Li-Yang Dou Yu Wang Yan Xu Lian-Feng Chen Xiao-Wei Yan 《Journal of lipid research》2015,56(3):682-691
We investigated ATP-binding cassette transporters A1/G1 expression and function in mediating cholesterol efflux by examining the macrophages of cigarette-smoking patients with coronary artery disease (CAD) before and after smoking abstinence. Peripheral blood monocyte cells were collected from nonsmokers (n = 17), non-CAD (NCAD) smokers (n = 35), and CAD smokers (n = 32) before and after 3 months of smoking cessation. We found that the ABCA1 expression level was lower in macrophages from NCAD and CAD smokers than from nonsmokers at baseline. The ABCA1 function of mediating cholesterol efflux was reduced in NCAD and CAD smokers as compared with nonsmokers. After 3 months of smoking cessation, ABCA1 expression and function were improved in CAD smokers. However, ABCG1 expression and function did not change after smoking cessation. Furthermore, ABCA1 expression was inhibited by tar in human acute monocytic leukemia cell line THP-1-derived macrophages through the inhibition of liver X receptors. Nicotine and carbon monoxide did not inhibit ABCA1 expression. Our results indicate that chronic cigarette smoking impaired ABCA1-mediated cholesterol efflux in macrophages and that tobacco abstinence reversed the function and expression of ABCA1, especially in CAD patients. It was tobacco tar, rather than nicotine or carbon monoxide, that played a major role in the tobacco-induced disturbance of cellular cholesterol homeostasis. 相似文献
5.
6.
7.
8.
9.
10.
Junyu Xiao Xiao-Wei Chen Brian A. Davies Alan R. Saltiel David J. Katzmann Zhaohui Xu 《Molecular biology of the cell》2009,20(15):3514-3524
The ESCRT machinery functions in several important eukaryotic cellular processes. The AAA-ATPase Vps4 catalyzes disassembly of the ESCRT-III complex and may regulate membrane deformation and vesicle scission as well. Ist1 was proposed to be a regulator of Vps4, but its mechanism of action was unclear. The crystal structure of the N-terminal domain of Ist1 (Ist1NTD) reveals an ESCRT-III subunit-like fold, implicating Ist1 as a divergent ESCRT-III family member. Ist1NTD specifically binds to the ESCRT-III subunit Did2, and cocrystallization of Ist1NTD with a Did2 fragment shows that Ist1 interacts with the Did2 C-terminal MIM1 (MIT-interacting motif 1) via a novel MIM-binding structural motif. This arrangement indicates a mechanism for intermolecular ESCRT-III subunit association and may also suggest one form of ESCRT-III subunit autoinhibition via intramolecular interaction. 相似文献