全文获取类型
收费全文 | 47754篇 |
免费 | 4631篇 |
国内免费 | 5882篇 |
出版年
2024年 | 28篇 |
2023年 | 584篇 |
2022年 | 824篇 |
2021年 | 2371篇 |
2020年 | 1777篇 |
2019年 | 2252篇 |
2018年 | 2125篇 |
2017年 | 1681篇 |
2016年 | 2203篇 |
2015年 | 3190篇 |
2014年 | 3857篇 |
2013年 | 4048篇 |
2012年 | 4852篇 |
2011年 | 4401篇 |
2010年 | 2803篇 |
2009年 | 2493篇 |
2008年 | 2790篇 |
2007年 | 2463篇 |
2006年 | 2221篇 |
2005年 | 1796篇 |
2004年 | 1485篇 |
2003年 | 1337篇 |
2002年 | 1188篇 |
2001年 | 853篇 |
2000年 | 720篇 |
1999年 | 670篇 |
1998年 | 433篇 |
1997年 | 367篇 |
1996年 | 345篇 |
1995年 | 302篇 |
1994年 | 308篇 |
1993年 | 210篇 |
1992年 | 227篇 |
1991年 | 172篇 |
1990年 | 144篇 |
1989年 | 131篇 |
1988年 | 116篇 |
1987年 | 70篇 |
1986年 | 83篇 |
1985年 | 78篇 |
1984年 | 46篇 |
1983年 | 41篇 |
1982年 | 37篇 |
1981年 | 25篇 |
1980年 | 13篇 |
1979年 | 21篇 |
1978年 | 9篇 |
1974年 | 8篇 |
1973年 | 11篇 |
1971年 | 8篇 |
排序方式: 共有10000条查询结果,搜索用时 109 毫秒
1.
2.
3.
Chungwen Wei Eugene Storozynsky A. J. McAdam Kun-Yun Yeh Brian R. Tilton Richard A. Willis Richard K. Barth R. John Looney Edith M. Lord J. G. Frelinger 《Cancer immunology, immunotherapy : CII》1996,42(6):362-368
Human prostate-specific antigen (PSA) has a highly restricted tissue distribution. Its expression is essentially limited
to the epithelial cells of the prostate gland. Moreover, it continues to be synthesized by prostate carcinoma cells. This
makes PSA an attractive candidate for use as a target antigen in the immunotherapy of prostate cancer. As a first step in
characterizing the specific immune response to PSA and its potential use as a tumor-rejection antigen, we have incorporated
PSA into a well-established mouse tumor model. Line 1, a mouse lung carcinoma, and P815, a mouse mastocytoma, have been transfected
with the cDNA for human PSA. Immunization with a PSA-expressing tumor cell line demonstrated a memory response to PSA which
protected against subsequent challenge with PSA-expressing, but not wild-type, tumors. Tumor-infiltrating lymphocytes could
be isolated from PSA-expressing tumors grown in naive hosts and were specifically cytotoxic against a syngeneic cell line
that expressed PSA. Immunization with tumor cells resulted in the generation of primary and memory cytotoxic T lymphocytes
(CTL) specific for PSA. The isolation of PSA-specific CTL clones from immunized animals further demonstrated that PSA can
serve as a target antigen for antitumor CTL. The immunogenicity studies carried out in this mouse tumor model provide a rationale
for the design of methods to elicit PSA-specific cell-mediated immunity in humans.
Received: 4 April 1996 / Accepted: 31 May 1996 相似文献
4.
Cun-Feng Zhao Ran Wei Xian-Chun Zhang 《Cladistics : the international journal of the Willi Hennig Society》2020,36(4):443-445
Here, we publish Lepisorus sect. Paragramma (Blume) C.F. Zhao, R. Wei & X.C. Zhang as a combinatio nova to replace the section name in Zhao et al. (2020), which was published as a status nova and turned out to be an invalid name, because we cited an incorrect basionym. A revised infrageneric classification of Lepisorus also is proposed. 相似文献
5.
6.
7.
The Biology of CRISPR-Cas: Backward and Forward 总被引:1,自引:0,他引:1
Frank Hille Hagen Richter Shi Pey Wong Majda Bratovič Sarah Ressel Emmanuelle Charpentier 《Cell》2018,172(6):1239-1259
8.
Wei Lu 《Evolution; international journal of organic evolution》2020,74(8):1879-1880
What determines the rate at which species adapt to new climatic conditions? Weaver et al. found that the evolution of short larval periods promotes climatic niche evolution in salamanders in the genus Desmognathus. 相似文献
9.
10.