全文获取类型
收费全文 | 362694篇 |
免费 | 37172篇 |
国内免费 | 266篇 |
出版年
2018年 | 8378篇 |
2017年 | 8227篇 |
2016年 | 7355篇 |
2015年 | 5103篇 |
2014年 | 5623篇 |
2013年 | 7870篇 |
2012年 | 11495篇 |
2011年 | 16349篇 |
2010年 | 12203篇 |
2009年 | 11643篇 |
2008年 | 13997篇 |
2007年 | 15766篇 |
2006年 | 7974篇 |
2005年 | 9096篇 |
2004年 | 8370篇 |
2003年 | 8603篇 |
2002年 | 8093篇 |
2001年 | 11322篇 |
2000年 | 11459篇 |
1999年 | 9288篇 |
1998年 | 3643篇 |
1997年 | 3724篇 |
1996年 | 3688篇 |
1995年 | 3614篇 |
1994年 | 3609篇 |
1993年 | 3574篇 |
1992年 | 8278篇 |
1991年 | 8084篇 |
1990年 | 7854篇 |
1989年 | 7773篇 |
1988年 | 7337篇 |
1987年 | 7308篇 |
1986年 | 6743篇 |
1985年 | 6894篇 |
1984年 | 5806篇 |
1983年 | 5230篇 |
1982年 | 4199篇 |
1981年 | 4023篇 |
1980年 | 3650篇 |
1979年 | 5962篇 |
1978年 | 4675篇 |
1977年 | 4486篇 |
1976年 | 4273篇 |
1975年 | 4617篇 |
1974年 | 5054篇 |
1973年 | 4947篇 |
1972年 | 5114篇 |
1971年 | 4610篇 |
1970年 | 3654篇 |
1969年 | 3675篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
András Szilágyi István Scheuring David P. Edwards Jerome Orivel Douglas W. Yu 《Ecology letters》2009,12(12):1306-1316
Theory suggests that spatial structuring should select for intermediate levels of virulence in parasites, but empirical tests are rare and have never been conducted with castration (sterilizing) parasites. To test this theory in a natural landscape, we construct a spatially explicit model of the symbiosis between the ant-plant Cordia nodosa and its two, protecting ant symbionts, Allomerus and Azteca . Allomerus is also a castration parasite, preventing fruiting to increase colony fecundity. Limiting the dispersal of Allomerus and host plant selects for intermediate castration virulence. Increasing the frequency of the mutualist, Azteca , selects for higher castration virulence in Allomerus , because seeds from Azteca -inhabited plants are a public good that Allomerus exploits. These results are consistent with field observations and, to our knowledge, provide the first empirical evidence supporting the hypothesis that spatial structure can reduce castration virulence and the first such evidence in a natural landscape for either mortality or castration virulence. 相似文献
3.
E. Azizi A. R. Deslauriers N. C. Holt C. E. Eaton 《Biomechanics and modeling in mechanobiology》2017,16(5):1633-1643
The collagenous extracellular matrix (ECM) of skeletal muscle functions to transmit force, protect sensitive structures, and generate passive tension to resist stretch. The mechanical properties of the ECM change with age, atrophy, and neuromuscular pathologies, resulting in an increase in the relative amount of collagen and an increase in stiffness. Although numerous studies have focused on the effect of muscle fibrosis on passive muscle stiffness, few have examined how these structural changes may compromise contractile performance. Here we combine a mathematical model and experimental manipulations to examine how changes in the mechanical properties of the ECM constrain the ability of muscle fibers and fascicles to radially expand and how such a constraint may limit active muscle shortening. We model the mechanical interaction between a contracting muscle and the ECM using a constant volume, pressurized, fiber-wound cylinder. Our model shows that as the proportion of a muscle cross section made up of ECM increases, the muscle’s ability to expand radially is compromised, which in turn restricts muscle shortening. In our experiments, we use a physical constraint placed around the muscle to restrict radial expansion during a contraction. Our experimental results are consistent with model predictions and show that muscles restricted from radial expansion undergo less shortening and generate less mechanical work under identical loads and stimulation conditions. This work highlights the intimate mechanical interaction between contractile and connective tissue structures within skeletal muscle and shows how a deviation from a healthy, well-tuned relationship can compromise performance. 相似文献
4.
5.
6.
I. S. Voroshilova 《Biology Bulletin》2016,43(10):1301-1307
This review summarizes published data on the genetic markers used in studies of dreissenide invasions. Causes of genetic differences between local populations are discussed. It is shown that information about the genetic diversity of populations obtained by marker polymorphism analysis should be compared to study invasion directions. 相似文献
7.
Rapid advances in mass spectrometry have allowed for estimates of absolute concentrations across entire proteomes, permitting the interrogation of many important biological questions. Here, we focus on a quantitative aspect of human cancer cell metabolism that has been limited by a paucity of available data on the abundance of metabolic enzymes. We integrate data from recent measurements of absolute protein concentration to analyze the statistics of protein abundance across the human metabolic network. At a global level, we find that the enzymes in glycolysis comprise approximately half of the total amount of metabolic proteins and can constitute up to 10% of the entire proteome. We then use this analysis to investigate several outstanding problems in cancer metabolism, including the diversion of glycolytic flux for biosynthesis, the relative contribution of nitrogen assimilating pathways, and the origin of cellular redox potential. We find many consistencies with current models, identify several inconsistencies, and find generalities that extend beyond current understanding. Together our results demonstrate that a relatively simple analysis of the abundance of metabolic enzymes was able to reveal many insights into the organization of the human cancer cell metabolic network. 相似文献
8.
9.
Geek culture is a subculture of enthusiasts that is traditionally associated with obscure media (Japanese animation, science fiction, video games, etc.). However, geek culture is becoming increasingly mainstream; for example, in the past year alone, Dragon*Con, a major Geek convention in Atlanta, Georgia, attracted an attendance of over 57,000 members. The present article uses an individual differences approach to examine three theoretical accounts of geek culture. Seven studies (N = 2354) develop the Geek Culture Engagement Scale (GCES) to quantify geek engagement and assess its relationships to theoretically relevant personality and individual differences variables. These studies present evidence that individuals may engage in geek culture in order to maintain narcissistic self-views (the great fantasy migration hypothesis), to fulfill belongingness needs (the belongingness hypothesis), and to satisfy needs for creative expression (the need for engagement hypothesis). Geek engagement is found to be associated with elevated grandiose narcissism, extraversion, openness to experience, depression, and subjective well-being across multiple samples. These data lay the groundwork for further exploration of geek culture as well as provide a foundation for examining other forms of subculture participation. 相似文献
10.