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Aghasizadeh Malihe Safarian Hamideh Haqhani Mohamad Avan Amir Kazemi Tooba Ferns Gordon A. Esmaily Habibollah Miri-Moghaddam Ebrahim Ghayour-Mobarhan Majid 《Biochemical genetics》2022,60(2):738-754
Biochemical Genetics - There is a strong genetic predisposition to cardiovascular disease (CVD). Loss-of-function variants of the angiopoietin-like 3 (ANGPTL3) gene have been reported to be... 相似文献
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Ebrahim Miri-Moghaddam Yousef Mortazavi Alireza Nakhaee Abdurrashid Khazaei Feizabad 《Biochemical genetics》2013,51(1-2):131-138
To determine the prevalence of G6PD deficiency and a Mediterranean mutation among males in southeastern Iran, we studied 1,097 Sistani and Balouch schoolboys. A questionnaire was used to collect demographic data and a history of malaria infection; blood samples were evaluated for G6PD deficiency and the G6PD Mediterranean mutation. Of the 1,097 boys screened, 175 were G6PD deficient (5.8 % of the Sistani boys and 19.3 % of the Balouch boys). The malaria survey indicated that among Balouch subjects, malaria infection was about 14 times that of Sistani subjects. Molecular characterization of G6PD-deficient samples revealed a general frequency of 85.1 % for the Mediterranean variant among all subjects (75 % among Sistani and 86.2 % among Balouch cases). The high prevalence of G6PD deficiency among Balouch populations confirms the hypothesis that the distribution of G6PD deficiency is concordant with the geographic distribution of malaria. 相似文献
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