全文获取类型
收费全文 | 925篇 |
免费 | 81篇 |
出版年
2023年 | 6篇 |
2021年 | 9篇 |
2020年 | 6篇 |
2019年 | 11篇 |
2018年 | 13篇 |
2017年 | 18篇 |
2016年 | 17篇 |
2015年 | 39篇 |
2014年 | 35篇 |
2013年 | 39篇 |
2012年 | 53篇 |
2011年 | 59篇 |
2010年 | 30篇 |
2009年 | 36篇 |
2008年 | 45篇 |
2007年 | 33篇 |
2006年 | 48篇 |
2005年 | 26篇 |
2004年 | 40篇 |
2003年 | 22篇 |
2002年 | 24篇 |
2001年 | 36篇 |
2000年 | 43篇 |
1999年 | 23篇 |
1998年 | 18篇 |
1997年 | 16篇 |
1996年 | 11篇 |
1995年 | 8篇 |
1994年 | 8篇 |
1993年 | 6篇 |
1992年 | 15篇 |
1991年 | 21篇 |
1990年 | 16篇 |
1989年 | 9篇 |
1988年 | 17篇 |
1987年 | 7篇 |
1986年 | 8篇 |
1985年 | 11篇 |
1984年 | 12篇 |
1983年 | 9篇 |
1982年 | 5篇 |
1981年 | 5篇 |
1980年 | 9篇 |
1979年 | 13篇 |
1975年 | 8篇 |
1974年 | 12篇 |
1973年 | 10篇 |
1971年 | 6篇 |
1970年 | 4篇 |
1969年 | 4篇 |
排序方式: 共有1006条查询结果,搜索用时 15 毫秒
1.
2.
Torkel Wadström Siiri Hirmo Hajdi Novak Antonio Guzman Martina Ringnér-Pantzar Meeme Utt Pär Aleljung 《Current microbiology》1997,34(5):267-272
Helicobacter pylori adhere to Kato III and Hela S3
cells in monolayer cultures. To explore whether cell surface glycoconjugates
on these two cell lines mediate binding of H. pylori, various
carbohydrates, glycoproteins, and glycolipids were tested to inhibit H.
pylori cell adhesion. The adhesion was measured (i) with a urease-based
assay and (ii) by cells stained with fluorescein. Sodium periodate and
sialidase treatment (but not α- or β-galactosidase, heparitinase,
lysozyme, or trypsin) inhibited H. pylori binding to both cell lines.
Sulfatides and sulfated glycoconjugates (50 μg/ml) but not heparin or a
number of simple carbohydrates inhibited binding (1 mg/ml). The two H.
pylori strains studied (CCUG 17874 and strain 25) showed high binding of
soluble 125I-labeled heparin and other sulfated carbohydrate
compounds.
Received: 5 July 1996 / Accepted: 17 October 1996 相似文献
3.
Journal of Mathematical Biology - We consider the goal of predicting how complex networks respond to chronic (press) perturbations when characterizations of their network topology and interaction... 相似文献
4.
5.
Psychopathological perspectives 总被引:1,自引:0,他引:1
6.
Evan D. Kharasch Raymond F. Novak 《Biochemical and biophysical research communications》1982,108(3):1346-1352
Ametantrone and mitoxantrone, two new anthracenedione antineoplastic agents, produced a concentration-dependent inhibition of hepatic microsomal lipid peroxidation. Malondialdehyde production was diminished from 10.6 nmoles/mg/60 min to 3.3 and 5.4 nmoles/mg/60 min, in the presence of 100 μM mitoxantrone and ametantrone, respectively. Under similar conditions, Adriamycin stimulated lipid peroxidation over twofold. In addition, both mitoxantrone and ametantrone inhibited Adriamycin-stimulated lipid peroxidation, with 50% inhibition occurring at concentrations of 4 and 6 μM, respectively. Microsomal superoxide production was not significantly inhibited at anthracenedione concentrations which markedly decreased lipid peroxidation, suggesting that inhibition of lipid peroxidation was not the result of inhibition of superoxide generation. These results correlate with the lack of anthracenedione cardiotoxicity and also demonstrate anthracenedione inhibition of lipid peroxidation at micromolar concentrations; an observation with potential therapeutic significance. 相似文献
7.
The direct effects of the inflammatory mediators, histamine (HI) and serotonin (SE), on the glucose metabolism of Hymenolepis diminuta in vitro were studied by analyzing the excretory products from culture media, containing D-1-13C-glucose and various concentrations of HI and/or SE, by 1H-nuclear magnetic resonance (n.m.r.) spectroscopy. The results revealed that HI markedly accelerated the glycolysis process by increasing the amount of lactate production. The increased glycolytic activity was reflected in a concentration-dependent increase in glucose uptake. Excretion of acetate was also stimulated by HI. A low concentration of SE significantly increased succinate, acetate and lactate excretions, whereas a high concentration had little effect on lactate production and significantly decreased succinate and acetate excretions. A combination of HI and SE treatment at a low concentration had no significant effect, but at a high concentration showed an additive effect, with an increase in lactate production, a decrease in succinate production and an increase in glucose uptake. Thus this work confirms that HI and SE directly influence, albeit differently, energy metabolism of the tapeworm H. diminuta. 相似文献
8.
9.
10.
Six species of bacteria (family Enterobacteriaceae) not commonly reported as associated with disease in American alligators (Alligator mississippiensis) were documented, suggesting that Aeromonas is not the only bacterium responsible for septicemia in crocodilians. These included Citrobacter freundii, Enterobacter agglomerans, Proteus sp., Morganella morganii, Serratia marcescens, and Klebsiella oxytoca. Clinical signs of disease included intensive basking, anorexia, lethargy, flaccid limb paralysis, stomatitis, and dermatitis. Our data indicated that early treatment with broad-spectrum antibiotics was preferable to waiting for sensitivity results. 相似文献