海南省鼻咽癌三个高发家系报告

本文调查了鼻咽癌聚集的10个家系。在3个高发家族中,家系1两代11人中有4 人患鼻咽癌;家系2同代6人中有3人患鼻咽癌;家系3同胞5人中有3人患鼻咽癌。我们从肿瘤流行病学、病理类型及其血缘关系作了分析,认为鼻咽癌具有垂直和水平的家族发生 倾向,支持鼻咽癌有遗传倾向的看法。 Abstract:We studied the genealogy with nasopharyngeal carcinoma(NPC)and found 25 patients (18 males,7 females)with NPC in 10 families,aged from 13 to 60.The bron of the same parents were 12 patients,accounting for 48% among these patients.Both male and female patients were found in five families;the patients in four families were all male;there were all female patients in the only one family;At the sametime,21 patients with NPC were the first kinsfolk in 8 families,accounting for 84%.Besides,we looked into 3 families with high incidence;there were 4 out of 11 family members suffering from NPC in the first genealogy in 2 generations;3 of 6 brons of the same parents were ill with NPC in the third genealogy.Based on the studies of cancer epidemiology,pathology and genealogy,our results suggested that the family incidence of NPC had vertical and horizontal thndency,and that genetic factors played a decisive role in NPC incidence.     

海南省鼻咽癌三个高发家系报告

本文调查了鼻咽癌聚集的10个家系。在3个高发家族中,家系1两代11人中有4 人患鼻咽癌;家系2同代6人中有3人患鼻咽癌;家系3同胞5人中有3人患鼻咽癌。我们从肿瘤流行病学、病理类型及其血缘关系作了分析,认为鼻咽癌具有垂直和水平的家族发生 倾向,支持鼻咽癌有遗传倾向的看法。 Abstract:We studied the genealogy with nasopharyngeal carcinoma(NPC)and found 25 patients (18 males,7 females)with NPC in 10 families,aged from 13 to 60.The bron of the same parents were 12 patients,accounting for 48% among these patients.Both male and female patients were found in five families;the patients in four families were all male;there were all female patients in the only one family;At the sametime,21 patients with NPC were the first kinsfolk in 8 families,accounting for 84%.Besides,we looked into 3 families with high incidence;there were 4 out of 11 family members suffering from NPC in the first genealogy in 2 generations;3 of 6 brons of the same parents were ill with NPC in the third genealogy.Based on the studies of cancer epidemiology,pathology and genealogy,our results suggested that the family incidence of NPC had vertical and horizontal thndency,and that genetic factors played a decisive role in NPC incidence.