排序方式: 共有14条查询结果,搜索用时 15 毫秒
1.
Lanosterol and ergosterol are the active principles with potential pharmacological activities in Inonotus obliquus. However, the two sterols are less accumulated in cultured mycelia of the fungus. In this study, different carbon and nitrogen sources and pH levels together with three metal ions were assayed for their effects on accumulation of the two sterols in the fungus. Among the tested media the growth medium consisting of glucose (1.5%), rice powder (0.5%), yeast extract (0.4%), wheat bran (0.1%), KH2PO4 (0.01%) and MgSO4?7H2O (0.05%) with pH level at 6.5 yielded a maximum production of the two sterols, which can further be increased following the treatment of Ag+, Cu2+ and Ca2+. Supplementing Ag+ at concentrations of 0.28 and 0.35?mol partially inhibited ergosterol biosynthesis, leading to an enhanced accumulation of lanosterol, the presence of intermediates of ergosterol biosynthetic pathway and a reduced accumulation of ergosterol in cultured mycelia of I. obliquus. 相似文献
2.
3.
家兔延髓腹外侧区内注射荷包牡丹碱对安定降低心脏功能的影响 总被引:1,自引:0,他引:1
家兔48只,用乌拉坦(1g/kg)静脉麻醉,三碘季铵酚制动,在人工呼吸下进行实验。静脉注射安定(0.5mg/kg)以及侧脑室注射氟安定(2mg溶于50μl人工脑脊液中)或γ-氨基丁酸(GABA)(300μg溶于50μl人工脑脊液中)都可降低心室内压峰值(PLVP),减少心力环面积(ACFL)和心室内压最大上升速率(dp/dt_(max))。安定和氟安定对PLVP、ACFL和dp/dt_(max)的抑制作用可被预先在侧脑室注射GABA受体拮抗剂印防己毒素(15μg溶于50μl人工脑脊液中)或双侧延髓腹外侧头端区(γVLM)微量注射GABA受体拮抗剂荷包牡丹碱(3μg溶于0.5μl生理盐水)所阻断。而在延髓网状巨细胞核中间部、网状小细胞核、孤束核或面神经核内注射同样剂量的荷包牡丹碱则不能阻断。 这些结果提示:延髓腹侧部GABA受体的激活可抑制心脏功能,安定对心脏功能的抑制作用可能通过激活延髓腹侧区GABA受体而实现。 相似文献
4.
黄酮类化合物是桦褐孔菌菌丝体中多酚类化合物的重要组成部分,也是该菌治疗众多疾病的有效成分之一。然而人工培养桦褐孔菌黄酮等酚类化合物积累甚少,导致药理活性的明显下降。为此,我们研究了3种氨基酸和4种霉菌水提物对深层发酵桦褐孔菌黄酮的积累及其抗氧化能力的影响。在所试验的3种氨基酸和4种霉菌水提物中,L-酪氨酸,黄曲霉和毛霉水提物能有效地增加该菌黄酮的积累。人工培养菌体中的黄酮至少由4种黄酮苷组成,苷元分别是槲皮素、柚皮素、山奈酚和异鼠李素。深层发酵菌丝体具有一定的抗氧化能力,并与总黄酮的含量呈正相关。由L-酪氨酸,黄曲霉和毛霉水提物调控生长的桦褐孔菌菌丝体,能有效地清除超氧阴离子、羟基自由基和DPPH自由基。 相似文献
5.
7.
不同培养基和三种金属离子对桦褐孔菌培养菌丝体的羊毛甾醇和麦角甾醇积累的影响 总被引:1,自引:0,他引:1
Lanosterol and ergosterol are the active principles with potential pharmacological activities in Inonotus obliquus. However, the two sterols are less accumulated in cultured mycelia of the fungus. In this study, different carbon and nitrogen sources and pH levels together with three metal ions were assayed for their effects on accumulation of the two sterols in the fungus. Among the tested media the growth medium consisting of glucose (1.5%), rice powder (0.5%), yeast extract (0.4%), wheat bran (0.1%), KH2PO4 (0.01%) and MgSO4·7H2O (0.05%) with pH level at 6.5 yielded a maximum production of the two sterols, which can further be increased following the treatment of Ag+, Cu2+ and Ca2+. Supplementing Ag+ at concentrations of 0.28 and 0.35μmol partially inhibited ergosterol biosynthesis, leading to an enhanced accumulation of lanosterol, the presence of intermediates of ergosterol biosynthetic pathway and a reduced accumulation of ergosterol in cultured mycelia of I. 相似文献
8.
江苏省(含上海市)爬行动物区系及地理区划 总被引:1,自引:1,他引:0
关于江苏的爬行动物 ,曾有Gee(1 91 9)报道过苏州的少数种类 ,孙宗彭 (1 92 6)就南京的蜥蜴类 ,张宗汉及方炳文 (1 93 1 )就南京的蛇类及龟鳖类分别作过研究 ;Sowerby(1 93 2 )曾涉及上海的爬行动物 ;在Pope(1 93 5 )的专著中收集有各家论文中有关江苏的爬行动物的记录 ;陈义 (1 962 )报导了南京附近的二种龟鳖类 ;《中国动物图谱———爬行动物》(1 962 )也有新资料 ;周开亚 (1 964)对江苏省爬行动物的地理分布及地理区划作了详细的叙述与讨论。在其后的几十年中随着调查工作的深入 ,对江苏省的爬行动物无论在属、种的数量及… 相似文献
9.
蟾酥、蟾皮、蟾衣提取物对心肌细胞膜ATP酶的影响 总被引:3,自引:0,他引:3
用中华大蟾蜍蟾酥、蟾皮、蟾衣脂溶性及水溶性提取物研究其对小鼠心肌细胞膜Na -K -ATP酶、Ca2 -ATP酶和Mg2 -Ca2 -ATP酶活性影响,同时以华蟾素注射液为对照.结果 表明:所有提取物均可抑制心肌细胞膜的上述3种ATP酶活性,其中对Na -K -ATP酶抑制作用较强的有蟾皮脂溶性和蟾酥脂溶性成分,对Ca2 -ATP酶和对Mg2 -Ca2 -ATP酶的影响结果相类似,作用较强的有蟾皮水溶性成分和华蟾素. 相似文献
10.