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慢性阻塞性肺疾病是呼吸系统常见慢性疾病。该疾病的发病与环境及多基因变异有关。近年的研究显示,人音猬因子相互作用蛋白基因参与多个系统疾病的发生发展,尤其对于呼吸系统该基因与慢性阻塞性肺疾病发病密切相关,该基因上某些单核苷酸多态性与慢性阻塞性肺疾病易感性相关,且在慢性阻塞性肺疾病患者肺组织内存在该基因低表达。另外,该基因与FEV1和FEV1/FVC关系密切,对肺功能有保护作用。目前的研究提示该基因和音猬信号通路在肺胚胎发育、基因表达调控、细胞增殖、细胞凋亡和平滑肌修复等方面发挥着重要调控作用,为慢性阻塞性肺疾病发病机制的研究指明了方向。本文就人音猬因子相互作用蛋白基因与慢性阻塞性肺疾病相关性的研究进展作一综述。 相似文献
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Ling Yang Li-Shu Wang Xiaoxin Chen Zoran Gatalica Suimin Qiu Zhihua Liu Gary Stoner Hongwei Zhang Heidi Weiss Jingwu Xie 《International Journal of Biochemistry and Molecular Biology》2012,3(1):46-57
Hedgehog (Hh) signaling is frequently activated in human cancer, including
esophageal cancer. Most esophageal cancers are diagnosed in the advanced stages,
therefore, identifying the very alterations that drive esophageal carcinogenesis
may help designing novel strategies to diagnose and treat the disease. Analysis
of Hh signaling in precancerous lesions is a critical first step in determining
the significance of this pathway for carcinogenesis. Here we report our data on
Hh target gene expression in 174 human esophageal specimens [28 esophageal
adenocarcinomas (EAC), 19 Barrett’s esophagus, 103 cases of esophageal
squamous cell carcinoma (ESCC), and 24 of squamous dysplastic lesions], and in
two rat models of esophageal cancer. We found that 96% of human EAC express Hh
target genes. We showed that PTCH1 expression is the most reliable biomarker. In
contrast to EAC, only 38% of ESCC express Hh target genes. We found activation
of Hh signaling in precancerous lesions of ESCCs and EACs in different degrees
(21% and 58% respectively). Expression of Hh target genes is frequently detected
in severe squamous dysplasia/ carcinoma in situ (p=0.04) and
Barrett’s esophagus (p=0.01). Unlike EAC, sonic hedgehog (Shh) expression
was rare in ESCCs. Consistent with the human specimen data, we found a high
percentage of Hh signaling activation in precancerous lesions in rat models.
These data indicate that Hh signaling activation is an early molecular event in
the development of esophageal cancer, particularly EAC. 相似文献
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