人音猬因子相互作用蛋白基因与慢性阻塞性肺疾病

慢性阻塞性肺疾病是呼吸系统常见慢性疾病。该疾病的发病与环境及多基因变异有关。近年的研究显示,人音猬因子相互作用蛋白基因参与多个系统疾病的发生发展,尤其对于呼吸系统该基因与慢性阻塞性肺疾病发病密切相关,该基因上某些单核苷酸多态性与慢性阻塞性肺疾病易感性相关,且在慢性阻塞性肺疾病患者肺组织内存在该基因低表达。另外,该基因与FEV1和FEV1/FVC关系密切,对肺功能有保护作用。目前的研究提示该基因和音猬信号通路在肺胚胎发育、基因表达调控、细胞增殖、细胞凋亡和平滑肌修复等方面发挥着重要调控作用,为慢性阻塞性肺疾病发病机制的研究指明了方向。本文就人音猬因子相互作用蛋白基因与慢性阻塞性肺疾病相关性的研究进展作一综述。

The Role of HHIP in COPD

Chronic obstructive pulmonary disease is a common chronic respiratory diseases. Pathogenesis of COPD related to environmental and genetic variations. The present study confirms HHIP gene is associated with the occurrence and development of multiple system disease. Especially, HHIP gene is associated with COPD.In the current study, SNPs near HHIP were found to be associated with susceptibility of COPD. Genetic variants in HHIP are associated with FEV1and FEV1 / FVC in subjects with COPD. HHIP protect pulmonary function. The genes and the Hh signaling pathway has been implicated in regulating gene expression in the lung, embryonic development, cell proliferation, apoptosis and smooth muscle repair. HHIP plays a role in development of COPD.