Endogenous tissue engineering: PTH therapy for skeletal repair

Based on its proven anabolic effects on bone in osteoporosis patients, recombinant parathyroid hormone (PTH_1-34) has been evaluated as a potential therapy for skeletal repair. In animals, the effect of PTH_1-34 has been investigated in various skeletal repair models such as fractures, allografting, spinal arthrodesis and distraction osteogenesis. These studies have demonstrated that intermittent PTH_1-34 treatment enhances and accelerates the skeletal repair process via a number of mechanisms, which include effects on mesenchymal stem cells, angiogenesis, chondrogenesis, bone formation and resorption. Furthermore, PTH_1-34 has been shown to enhance bone repair in challenged animal models of aging, inflammatory arthritis and glucocorticoid-induced bone loss. This pre-clinical success has led to off-label clinical use and a number of case reports documenting PTH_1-34 treatment of delayed-unions and non-unions have been published. Although a recently completed phase 2 clinical trial of PTH_1-34 treatment of patients with radius fracture has failed to achieve its primary outcome, largely because of effective healing in the placebo group, several secondary outcomes are statistically significant, highlighting important issues concerning the appropriate patient population for PTH_1-34 therapy in skeletal repair. Here, we review our current knowledge of the effects of PTH_1-34 therapy for bone healing, enumerate several critical unresolved issues (e.g., appropriate dosing regimen and indications) and discuss the long-term potential of this drug as an adjuvant for endogenous tissue engineering.     

DFT studies of the phenol adsorption on boron nitride sheets

We perform first principles total energy calculations to investigate the atomic structures of the adsorption of phenol (C₆H₅OH) on hexagonal boron nitride (BN) sheets. Calculations are done within the density functional theory as implemented in the DMOL code. Electron-ion interactions are modeled according to the local-spin-density-approximation (LSDA) method with the Perdew-Wang parametrization. Our studies take into account the hexagonal h-BN sheets and the modified by defects d-BN sheets. The d-BN sheets are composed of one hexagon, three pentagons and three heptagons. Five different atomic structures are investigated: parallel to the sheet, perpendicular to the sheet at the B site, perpendicular to the sheet at the N site, perpendicular to the central hexagon and perpendicular to the B-N bond (bridge site). To determine the structural stability we apply the criteria of minimum energy and vibration frequency. After the structural relaxation phenol molecules adsorb on both h-BN and d-BN sheets. Results of the binding energies indicate that phenol is chemisorbed. The polarity of the system increases as a consequence of the defects presence which induces transformation from an ionic to covalent bonding. The elastic properties on the BN structure present similar behavior to those reported in the literature for graphene.     

小儿遗传病4,382例分析

遗传病是小儿常见病之一,它不仅直接影响小儿的健康,而且还会传递到后代。可是有关小儿遗传病发病情况的资料,国内尚未见到。为了解住院患儿中遗传病的出现频率及规律,为今后防治工作提供参考,现将我院近5年来住院患儿中遗传病的发病情况作一初步报道。     

某部作训前后真菌性皮肤病调查

为进一步提高部队作训期间皮肤病健康保障的质量，针对性地开展常见真菌性皮肤病的预防、治疗和健康宣教工作，笔者于2009年7～10月对某部执行任务前后全体官兵真菌感染性皮肤病的发病情况进行了调查。     

毛唇芋兰根茎的诱导与块茎形成

植物名称:毛唇芋兰(Nervilia fordii Hance)Schltr.) 材料类别:块茎培养条件: (一)诱导根茎的培养基:H BA 2mg/l(单位下同)。根茎继代培养基:H BA 0.25。均添加2％蔗糖,0.8％琼脂,pH5.8,每日用日光灯加光10小时,于26±1℃培养室中培养。 (二)块茎形成:将根茎转接于H BA 0.25培养中继代扩大培养,待根茎增殖达到高峰后,生     

中国长斑蚜属6新种及中华彩斑蚜新属新种记述(同翅目,斑蚜科)

本文记述我国长斑蚜属Tinocallis Matsumura 11种,其中包括6新种;并记述中华彩斑蚜Sinotherioaphis pterothorax zhang et zhong,新属新种。文中所用量度单位为毫米。模式标本存中国科学院动物研究所。