全文获取类型
收费全文 | 2664篇 |
免费 | 137篇 |
国内免费 | 129篇 |
出版年
2023年 | 46篇 |
2022年 | 37篇 |
2021年 | 58篇 |
2020年 | 69篇 |
2019年 | 96篇 |
2018年 | 72篇 |
2017年 | 54篇 |
2016年 | 54篇 |
2015年 | 88篇 |
2014年 | 92篇 |
2013年 | 236篇 |
2012年 | 84篇 |
2011年 | 62篇 |
2010年 | 66篇 |
2009年 | 99篇 |
2008年 | 91篇 |
2007年 | 93篇 |
2006年 | 123篇 |
2005年 | 119篇 |
2004年 | 111篇 |
2003年 | 108篇 |
2002年 | 116篇 |
2001年 | 83篇 |
2000年 | 61篇 |
1999年 | 64篇 |
1998年 | 63篇 |
1997年 | 55篇 |
1996年 | 66篇 |
1995年 | 52篇 |
1994年 | 64篇 |
1993年 | 67篇 |
1992年 | 51篇 |
1991年 | 67篇 |
1990年 | 42篇 |
1989年 | 36篇 |
1988年 | 22篇 |
1987年 | 38篇 |
1986年 | 15篇 |
1985年 | 17篇 |
1984年 | 23篇 |
1983年 | 6篇 |
1982年 | 17篇 |
1981年 | 7篇 |
1980年 | 9篇 |
1979年 | 14篇 |
1978年 | 3篇 |
1976年 | 6篇 |
1975年 | 3篇 |
1974年 | 2篇 |
1973年 | 2篇 |
排序方式: 共有2930条查询结果,搜索用时 15 毫秒
31.
《Free radical research》2013,47(8):906-917
AbstractIron is universally abundant and no life can exist without it. However, iron levels should be maintained within a narrow range. Iron deficiency causes anaemia, whereas excessive iron increases cancer risk, presumably by free radical generation. Several pathological conditions such as genetic haemochromatosis, chronic viral hepatitis B and C, conditions related to asbestos fibre exposure and ovarian endometriosis have been recognized as iron overload-associated conditions that also increase human cancer risks. Iron's carcinogenicity has been documented in animal experiments. Surprisingly, these studies have revealed that the homozygous deletion of CDKN2A/2B is a major hallmark of iron-induced carcinogenesis. Recently, the hormonal regulation of iron metabolism has been elucidated. A commonly hypothesized mechanism may be the lack of any iron disposal pathway other than for bleeding and a mechanism of iron re-uptake as catechol chelate has been discovered. Iron overload in neurons via the ferroportin block may play a role in Alzheimer's disease. Furthermore, a recent epidemiological study reported that iron reduction by phlebotomy was associated with decreased cancer risks in a general population. Given that the required amounts of iron decrease during ageing, the fine control of body iron stores would be a wise strategy for chemoprevention of several diseases. 相似文献
32.
J. A. Fernandez-Pol 《Biological trace element research》1979,1(2):157-168
Studies were designed to characterize the plasma membrane polypeptide composition of normal rat kidney (NRK) and virus-transformed
NRK cells as a function of time following iron deprivation. Using this approach we found that rapid depletion of iron from
the cells increases the amounts of two membrane-associated glycoproteins of apparent MW 160,000 (160 K) and 130,000 (130 K)
in NRK cells. In contrast, virus-transformed NRK cells subjected to iron deprivation showed an altered induction phenomenon
manifested by reduced levels of both 160 K and 130 K and altered time-sequence of the induction. Possible relationship of
the 160 K and 130 K membrane-associated glycoproteins described in this study to growth control and viral transformation are
discussed. 相似文献
33.
34.
35.
M. B. H. Youdim Matthew A. Sills William E. Heydorn G. Joseph Creed David M. Jacobowitz 《Journal of neurochemistry》1986,47(3):794-799
Young rats (21 days old) made nutritionally iron deficient, by feeding them a semisynthetic diet containing skimmed milk for 5 weeks, had significantly lowered hemoglobin levels (5.2 +/- 4 g/100 ml). The nonheme iron content in caudate nucleus was decreased by 47%. The behavioral response of iron-deficient rats to apomorphine (2 mg/kg) and the density of 3,4-dihydroxyphenylethylamine (dopamine) D2 receptors, as measured by [3H]spiperone binding in caudate nucleus, were significantly reduced by 70 and 53%, respectively. The possibility that nutritional iron deficiency may affect protein content in brain was investigated by measuring the apparent concentration of proteins in caudate nucleus and nucleus accumbens from iron-deficient and control animals using two-dimensional gel electrophoresis. The data indicate that iron deficiency can affect content in these two brain regions. Significant changes in the content of 10 proteins were noted in the caudate nucleus and nucleus accumbens in iron-deficient rats. The albumin level was significantly increased in both regions studied, whereas the neuron-specific enolase level was increased in the nucleus accumbens and the glial fibrillary acidic protein level was reduced in the caudate nucleus. The significance of these protein content changes, as well as a reduction in content of a 94-kilodalton protein (a molecular size similar to that of the D2 dopamine receptor), remains to be established. 相似文献
36.
37.
Olga Babosova Katarina Kapralova Leona Raskova Kafkova Vladimir Korinek Vladimir Divoky Josef T. Prchal Lucie Lanikova 《Journal of cellular and molecular medicine》2019,23(11):7785-7795
The patients with mantle cell lymphoma (MCL) have translocation t(11;14) associated with cyclin D1 overexpression. We observed that iron (an essential cofactor of dioxygenases including prolyl hydroxylases [PHDs]) depletion by deferoxamine blocked MCL cells’ proliferation, increased expression of DNA damage marker γH2AX, induced cell cycle arrest and decreased cyclin D1 level. Treatment of MCL cell lines with dimethyloxalylglycine, which blocks dioxygenases involving PHDs by competing with their substrate 2‐oxoglutarate, leads to their decreased proliferation and the decrease of cyclin D1 level. We then postulated that loss of EGLN2/PHD1 in MCL cells may lead to down‐regulation of cyclin D1 by blocking the degradation of FOXO3A, a cyclin D1 suppressor. However, the CRISPR/Cas9‐based loss‐of‐function of EGLN2/PHD1 did not affect cyclin D1 expression and the loss of FOXO3A did not restore cyclin D1 levels after iron chelation. These data suggest that expression of cyclin D1 in MCL is not controlled by ENGL2/PHD1‐FOXO3A pathway and that chelation‐ and 2‐oxoglutarate competition‐mediated down‐regulation of cyclin D1 in MCL cells is driven by yet unknown mechanism involving iron‐ and 2‐oxoglutarate‐dependent dioxygenases other than PHD1. These data support further exploration of the use of iron chelation and 2‐oxoglutarate‐dependent dioxygenase inhibitors as a novel therapy of MCL. 相似文献
38.
39.
40.