枸橼酸铋雷尼替丁+克拉霉素7天根除幽门螺旋杆菌疗效观察

目的观察枸橼酸铋雷尼替丁(RBC) 克拉霉素根除幽门螺旋杆菌疗效。方法RBC 350Mg 克拉霉素500mg口服,每天2次,共7d。结果治疗后Hp的根除率为86．5％。结论RBC 克拉霉素7d根除Hp效果满意。     

甲状腺弥漫性大B细胞性淋巴瘤1例报告

1病例介绍患者,男,58岁,因发现颈前无痛性肿块20年,伴呼吸困难1个月,于2005年10月25日入院。无甲亢病史。查体:体温38.6℃,脉搏120次/分,呼吸21次/分,血压14.7/9.3kPa,各浅表淋巴结未触及,无皮肤潮红、肿胀及溃疡,未见血管曲张,甲状腺右叶触及约8.0cm×6.0cm×6.0cm大小的肿块,质硬,边界欠清,活动度差,无触痛,局部皮温不高,肿块可随吞咽上下移动,未闻及血管杂音。B超:颈前区实质性占位。CT:右侧甲状腺癌累及喉及气管上段,诊断为甲状腺癌侵及喉及气管。于2004年11月2日行甲状腺癌根治术、颈段气管、喉切除术、气管造口术。术后病理结合免疫…     

《蛇志》刊登广告信息

患儿,男,9岁,因反复浮肿、少尿1年9个月人院。患儿于2001年1月无诱因下出现全身浮肿、少尿,多次查尿常规：尿蛋白均为＋＋＋,无怕冷、反应迟钝。病后在当地医院住院治疗,诊断为肾病综合征,治疗20余天无好转,即转到上一级医院住院治疗,确诊为原发性肾病综合征（单纯型）。给予强的松治疗,浮肿消退,治疗4周后尿蛋白转阴而出院。出院后一直服强的松治疗,规则减量。此后患儿反复出现浮肿,少尿,     

麻醉诱导时血压下降对术后恶心呕吐的影响

目的：观察麻醉诱导时血压下降与术后恶心呕吐的关系.方法：选择ASAⅠ-Ⅱ级的经腹胆囊切除术患者40例,按麻醉诱导时血压比基础值下降的程度分为2组,每组20例.A组：SBP比基础血压下降〉30%;B组：SBP比基础血压下降〈30%.术后随访病人48小时,记录病人恶心呕吐的发生情况.结果：麻醉诱导时血压下降对术后恶心呕吐有明显影响.结论：麻醉期间维持血流动力学稳定能降低PONV的发生.     

治疗腹膜后血肿的临床探讨

目的:探讨治疗腹膜后血肿的临床疗效。方法:对腹膜后血肿106例分型、诊断及治疗进行了回顾性分析。结果:腹膜后血肿无特异性症状和体征,可通过休克、腹穿、放射、超声波、尿路及血管造影等提高诊断,手术79例,非手术19例,死亡8例。结论:对腹膜后血肿的早期诊断及救治是提高生存率的关键。     

外直肌悬吊后徙术矫治大角度外斜视

目的:探讨矫治大角度外斜视在采用超常量徙后外直肌时,肌肉断端的缝合位置问题及外直肌悬吊后徙术的可行性。方法:对2 0 0 1年以来的15例外斜视(斜视度最小为2 5°,最大为4 5°)的患者采用外直肌悬吊后徙的方法,即:在外直肌止端后1mm两侧缘各做一套环式缝合结扎后,于肌止端剪断外直肌。由肌止点向后约5mm处,将肌肉缝线平行外直肌上下缘穿过浅层巩膜约2mm后穿出巩膜。测量肌止点与拟行肌肉缝线结扎点后肌肉断端的距离是否与术前拟行后徙量相符。确定后结扎缝线,形成吊床状。结果:15例外斜视患者,11例行双眼外直肌超常量徙后,4例在双眼外直肌徙后同时联合单眼内直肌缩短术,外直肌徙后均采用悬吊式徙后方法,术后观察6 - 12个月,1例残留5°外斜,其余14例均达到正常眼位。结论:超常量徙后外直肌时,采用悬吊后徙方法,既减少了眼外肌与眼球筋膜的大范围粘连及手术操作困难时易带来的巩膜意外损伤,又达到了超常量徙后矫治大角度外斜视的目的。手术操作简便易行,值得临床应用。     

川芎嗪合并硫酸镁治疗妊高征大鼠的疗效及机制探讨

The aim of this study was to evaluate the outcome of treatment of pregnancy--induced hypertension (PIH) in rats by Ligustrazine collaborated with magnesium sulfate. PIH rat models were induced with Nomega-nitro-L-arginine methyl ester (L-NAME) infusing at 7 mg/kg per day via caudal vein for four days, then treated with Ligustrazine, magnesium sulfate, or both for three days. Rat blood pressure level was measured by the tail-cuff method, 24 hours urine protein was also assayed. The blood pressure and urine proteins of grouped PIH rats were recorded before the start and after the termination of therapy. The body length and the weight of fetal rats, the weight of placentals from pregnant rats were measured. The placental tissues, livers, kidneys of rats were investigated with integrated methods such as histopathologic observation with light microscopy, ultrastructural observation with transmission electron microscopy. L-NAME administration in pregnancy rats during the late pregnancy period had resulted in an rise of blood pressure, an increasing of urine protein, death rate of rat fetus, incidence of teratogenesis, and so on. Three groups of PIH rats treated with single magnesium sulfate, Ligustrazine, or Ligustrazine combined with magnesium sulfate showed an obvious dropping of the proteinuria, decompression of blood pressure (p<0.01, p<0.001), especially the treatment efficacy in the group of Ligustrazine combined with magnesium sulfate was more significant effective than other two groups (p<0.01, p<0.001). The treatment with both Ligustrazine and magnesium sulfate could increase the body length of newly born rats, the body weight of tomites and the placental weight, furthermore, reduce the rate of the teratosis of hindlimb-shortness (p<0.001). There were diffuse focal necrosis areas in the livers of PIH rats, their glomerular basement membrane had thickened extensively, the glomerular endothelium had swelled, extensive edema in the epithelia of renal tubule was demonstrated. The decidua and basal zone of the placentae of PIH rats all thickened, the microvilli of trophoblasts decreased. After treatment with ligustrazine especially with both Ligustrazine and magnesium sulfate, the necrosis of hepatocytes disappeared. The thickening of glomerular basement membrane in the group of ligustrazine or both Ligustrazine and magnesium sulfate treatment reduced; Moreover in the latter group the morphology of glomerular endothelium essentially recovered, the edema in cytoplasms of renal tubular epithelium reduced. The placental lesions were also relieved. The present results indicated the therapeutic effect by Ligustrazine collaborated with magnesium sulfate was better than a single use of Ligustrazine or magnesium sulfate. There were pathological alteration involved ischemia and anoxic in the placental tissues of PIH rats, resembled the placental pathological alteration of the human cases with PIH. The treatment with ligustrazine, and especially both Ligustrazine and magnesium sulfate in PIH rats could obviously relieve the lesions in lives, kidneys and placentae.     

大鼠与家兔生后各年龄阶段跖肌纤维的比较

应用建立在肌球蛋白重链异构体基础上的标准肌动球蛋白ATP酶和琥珀酸脱氢酶组织化学方法,分析大鼠和家兔出生后发育各年龄阶段跖肌纤维型分布。在生后2周至24周龄的大鼠和家兔Ⅰ、ⅡX型肌纤维百分比例减少,而ⅡA、ⅡB型纤维则增加。进行大量单肌纤维的组织化学特征的比较和相关性探讨。结果显示动物平均体重与跖肌的平均湿重随生后发育逐渐增加,Ⅰ、ⅡX、ⅡA及ⅡB型纤维均在生后各年龄组的全部肌肉内被发现,但出生后2日龄组是个例外。在生后发育期间,雄性大鼠和家兔ⅡB型纤维的平均肌纤维型构成要大于雌性大鼠和家兔,而雄性大鼠和家兔Ⅰ、ⅡX、ⅡA型三种氧化组织化学分类的肌纤维型构成均小于雌性大鼠和家兔。大鼠Ⅰ、ⅡX、ⅡA和ⅡB型纤维的平均横切面积显然要比家兔的同类型肌纤维要小。在大鼠和家兔可见明显的性别差异。大鼠和家兔的ⅡX型纤维横切面积是最小的,Ⅰ、ⅡA型纤维呈中等大小,ⅡB型纤维最大。该重要的测试有助于我们深入研究啮齿类动物快肌纤维生理特征的适应。     

桓仁林蛙蝌蚪胚后发育的初步观察

本文对桓仁林蛙蝌蚪胚后发育的过程和形态特征进行了观察、测量和描述,并与中国林蛙和昆嵛林蛙进行了比较.胚后发育可分为19期,对其后肢芽、趾、前肢的发育,唇齿的变化过程,口、鼻、眼的位置与形状,以及肛管与尾的变化等方面做了系统的描述.     

PCBP1在基因表达过程中的功能和作用机理

Poly（C）-binding protein 1 （PCBP 1）是一种RNA结合蛋白,其蛋白质相对分子质量约为38000。PCBP1含三个KH（hnRNP K homology）结构域,这些结构域对其结合RNA有重要作用。PCBP1的功能主要是参与基因转录及转录后调节,如前体mRNA的剪切、mRNA稳定性、mRNA翻译过程的沉默或增强等。本文主要对PCBP1参与的信号通路以及与人类疾病的关系进行综述,试图阐明PCBP1的生物学功能和作用机理。