Additivity-based design of the strongest possible turkey ovomucoid third domain inhibitors for porcine pancreatic elastase (PPE) and Streptomyces griseus protease B (SGPB)

We describe here successful designs of strong inhibitors for porcine pancreatic elastase (PPE) and Streptomyces griseus protease B (SGPB). For each enzyme two inhibitor variants were designed. In one, the reactive site residue (position 18) was retained and the best residues were substituted at contact positions 13, 14, and 15. In the other variant the best residues were substituted at all contact positions except the reactive site where a Gly was substituted. The four designed variants were: for PPE, T¹³E¹⁴Y¹⁵-OMTKY3 and T¹³E¹⁴Y¹⁵G¹⁸M²¹P³²V³⁶-OMTKY3, and for SGPB, S¹³D¹⁴Y¹⁵-OMTKY3 and S¹³D¹⁴Y¹⁵G¹⁸I¹⁹K²¹-OMTKY3. The free energies of association (ΔG⁰) of expressed variants have been measured with the proteases for which they were designed as well as with five other serine proteases and the results are discussed.     

石膏样小孢子菌面部感染1例并文献回顾

报道1例由石膏样小孢子菌感染所致的面癣.患者为5岁男童,外伤后致右侧面颊部红斑、丘疹、脓疱20余日于我科就诊.真菌镜检显示菌丝阳性;真菌培养生长石膏样小孢子菌.皮损外用酮康唑乳膏两周后复诊,痊愈.随诊观察1个月未见复发.     

Maghrebi Migrants and Writers: Liminality, Transgression and the Transferal of Identity

Migration research has generally neglected the individual, sacrificing him/her to macrosociological analyses. Some anthropologists, however, offer more analytically productive frameworks within which to comprehend the migrants’ experiences by considering them in terms of hybridity and liminality. I argue for the insight recognition of a liminal imaginary may bring to an understanding of transnational North African’s experiences by exploring the novelistic space-time constructed and shared by Francophone Maghrebi authors, including Tahar Ben Jelloun and Mehdi Charef. Recognizing in the Moroccan context the pertinence of a hegemonic patriarchal master-disciple matrix, in addition to a certain idea of liberty in regard to international relations and borders, I perceive these Francophone Maghrebi authors as pursuing a distinctive kind of freedom, one linked to their liminal positions. I take Victor Turner’s conception of the liminal a step further by pointing to the relevance of barzakh, an Arabic word theorized by the 13th century Andalusian philosopher Ibn al-Arabi as an isthmus and womb. I further build on this concept by focusing on the inarticulatable aspects and transgressive possibilities outside transnational structures and traditions.     

植物学研究态势——生命科学研究态势之一

作者采用科学文献计量学方法、分析比较方法等,通过对1993年至2002年9月的植物学论文文献量进行统计和分析,反映国内外著者、研究机构、国家等在植物分子细胞研究、植物与环境研究及药用植物研究三个方面的植物学文献产出能力和科学影响力状况,揭示国内外植物学研究发展态势。     

从科研论文量看世界生命科学的发展

应用美国ESI基本科学指标数据库,对1993年至2003年世界科研产出成果进行统计分析,反映国内外生命科学重点研究领域和学科分布特点,揭示我国与国外相比存在的差距。从文献计量学角度,对我国生命科学的发展提出了建设性意见。     

Phyto-mellitus: A phyto-chemical database for diabetes

Herbs are the base used for treatment in Ayurveda. We describe a database named Phyto-Mellitus with information on plants traditionally used for diabetes with their chemical constituents. The active principles of these plants are antioxidant and free radical scavenging.

Availability

http://www.bicmlacw.org/bt/     

A database for anti-diabetic plants with clinical / experimental trials

A number of plants have been described in Ayurveda and other traditional medicine for the management of diabetes. However, information about them is not easily available. Active constituents of any medicinal plant define the efficacy and safety of treatment to control hyperglycemia. We describe the database to maintain the record of medicinal plants having anti-hyperglycemic or anti-diabetic activity. The database contains information such as plant name, its geographical distribution, useful plant part, known dosage, active constituents, mechanism of action and clinical/experimental data. The database also includes information about plant raw material suppliers or manufacturers in India. The current database includes 238 plants species and 123 Indian industries using them. AVAILABILITY: The database is freely available at http://www.biotechpark.org.in/antidia/index.html.